Detailed information NTG0925380

Bioinformatically predicted

Overview

• Name: ciaH
• Type: Regulator
• Locus tag: VKP36_RS04600
• Genome accession: NZ_CP142357
• Coordinates: 926016..927326 (-)
• Length: 436 a.a.
• NCBI ID: WP_011184551.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain AW-534
• Function: Required for optimal comC expression (predicted from homology) Competence regulation

Genomic Context

Location: 921016..932326

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
VKP36_RS04575 (VKP36_04575)	-	921668..922720 (-)	1053	WP_002989701.1	BMP family lipoprotein	-
VKP36_RS04580 (VKP36_04580)	-	922814..923203 (-)	390	WP_011285547.1	cytidine deaminase	-
VKP36_RS04585 (VKP36_04585)	-	923808..924401 (-)	594	WP_010922352.1	class I SAM-dependent methyltransferase	-
VKP36_RS04590 (VKP36_04590)	coaA	924669..925589 (+)	921	WP_010922353.1	type I pantothenate kinase	-
VKP36_RS04595 (VKP36_04595)	rpsT	925643..925891 (+)	249	WP_009881183.1	30S ribosomal protein S20	-
VKP36_RS04600 (VKP36_04600)	ciaH	926016..927326 (-)	1311	WP_011184551.1	sensor histidine kinase	Regulator
VKP36_RS04605 (VKP36_04605)	ciaR	927319..927993 (-)	675	WP_002984519.1	response regulator transcription factor	Regulator
VKP36_RS04610 (VKP36_04610)	-	928340..930877 (-)	2538	WP_326624207.1	M1 family metallopeptidase	-
VKP36_RS04615 (VKP36_04615)	phoU	931082..931735 (-)	654	WP_002984514.1	phosphate signaling complex protein PhoU	-

Sequence

Protein

• Length: 436 a.a.
• Molecular weight: 50093.61 Da
• Isoelectric Point: 9.0837

>NTDB_id=925380 VKP36_RS04600 WP_011184551.1 926016..927326(-) (ciaH) [Streptococcus pyogenes strain AW-534]
MNKLKKEILSDNYNHFFHFFAVFTGIFVIMTIIILQIMRFGVYSSVDSSLVSVSNNASSYANRTMARISSFYFDTENNII
KALPDSDSSKLLGTPAANTDIILFSANGTILNAFDAFSNYQNFHLDKHRLGSIETTSLMNFYGQEEKYHTITVRVHIKNY
PAVAYMMAVVNVEQLDRANERYERIIIIVMSVFWLISILASIYLAKWSRKPILESYEKQKMFVENASHELRTPLAVLQNR
LESLFRKPNETILENSEHLASSLDEVRNMRILTTNLLNLARRDDGINPQWTHLDTDFFNAIFENYELVAKEYGKIFYFQN
QVNRSLRMDKALLKQLITILFDNAIKYTDKNGIIEIIVKTTDKNLLISVIDNGPGITDEEKKKIFDRFYRVDKARTRQTG
GFGLGLALAQQIVMSLKGNITVKDNDPKGSIFEVKL

Nucleotide

• Length: 1311 bp

>NTDB_id=925380 VKP36_RS04600 WP_011184551.1 926016..927326(-) (ciaH) [Streptococcus pyogenes strain AW-534]
ATGAATAAATTAAAAAAAGAGATTTTATCAGATAACTATAACCACTTTTTTCATTTTTTTGCGGTTTTTACAGGTATTTT
TGTCATTATGACTATTATTATCTTACAGATTATGCGGTTTGGCGTTTATTCGTCAGTTGACAGTAGTTTAGTTTCTGTTA
GTAATAATGCAAGTAGCTATGCTAATCGTACGATGGCTAGAATATCTTCTTTTTACTTTGATACTGAAAATAACATTATT
AAGGCGCTGCCTGATTCAGATAGTTCTAAGTTATTAGGAACGCCTGCAGCTAATACAGATATCATTTTGTTTAGTGCTAA
TGGAACAATTTTAAATGCTTTTGATGCGTTTTCTAACTATCAAAATTTTCATTTAGATAAACACCGTTTGGGGAGTATTG
AAACCACCAGTTTAATGAATTTTTATGGACAAGAAGAAAAATACCATACGATAACCGTAAGGGTTCATATCAAAAATTAT
CCTGCAGTTGCCTATATGATGGCAGTAGTAAATGTGGAACAATTAGACCGCGCTAATGAACGTTATGAGCGCATTATTAT
TATAGTTATGAGTGTTTTTTGGCTAATTTCTATTTTAGCAAGTATTTATTTAGCCAAGTGGAGCAGAAAACCTATTTTAG
AAAGCTATGAAAAACAAAAAATGTTTGTTGAAAATGCTAGTCATGAATTAAGGACCCCTTTGGCGGTCTTACAGAATCGT
CTGGAATCGCTTTTTCGTAAGCCCAACGAAACGATATTAGAAAATAGTGAGCATCTCGCTTCTAGTTTAGACGAGGTTCG
CAACATGCGCATCTTAACAACTAATTTATTAAATTTAGCAAGACGAGATGATGGCATTAATCCACAGTGGACTCATTTAG
ATACAGATTTTTTTAATGCTATTTTTGAGAATTATGAACTAGTTGCTAAAGAATATGGAAAAATATTTTATTTTCAGAAC
CAAGTCAATAGATCGTTAAGAATGGATAAGGCTTTACTAAAACAATTAATAACGATTTTATTTGACAATGCTATTAAATA
TACAGATAAAAATGGTATTATTGAAATTATAGTGAAAACAACGGACAAAAATTTATTAATTTCTGTTATTGATAATGGTC
CAGGGATAACAGATGAAGAAAAGAAAAAGATTTTTGATCGTTTTTATCGAGTTGACAAAGCTAGAACACGGCAAACAGGT
GGATTTGGCTTGGGGTTGGCTTTAGCTCAGCAAATCGTGATGTCTTTAAAAGGAAATATTACAGTAAAGGATAATGATCC
TAAAGGTAGTATTTTTGAAGTCAAACTATAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (329-436)

• His Kinase A (phospho-acceptor) domain (HisKA) (220-285)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaH	Streptococcus mutans UA159	57.895	100	0.58
ciaH	Streptococcus pneumoniae Rx1	51.37	100	0.516
ciaH	Streptococcus pneumoniae D39	51.37	100	0.516
ciaH	Streptococcus pneumoniae R6	51.37	100	0.516
ciaH	Streptococcus pneumoniae TIGR4	51.37	100	0.516