Detailed information NTG0925220

Bioinformatically predicted

Overview

• Name: ciaH
• Type: Regulator
• Locus tag: VKP53_RS04395
• Genome accession: NZ_CP142354
• Coordinates: 866232..867542 (+)
• Length: 436 a.a.
• NCBI ID: WP_326675189.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain 6745-99
• Function: Required for optimal comC expression (predicted from homology) Competence regulation

Genomic Context

Location: 861232..872542

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
VKP53_RS04380 (VKP53_04380)	phoU	861823..862476 (+)	654	WP_326675185.1	phosphate signaling complex protein PhoU	-
VKP53_RS04385 (VKP53_04385)	-	862681..865218 (+)	2538	WP_326675187.1	M1 family metallopeptidase	-
VKP53_RS04390 (VKP53_04390)	ciaR	865565..866239 (+)	675	WP_002984519.1	response regulator transcription factor	Regulator
VKP53_RS04395 (VKP53_04395)	ciaH	866232..867542 (+)	1311	WP_326675189.1	HAMP domain-containing sensor histidine kinase	Regulator
VKP53_RS04400 (VKP53_04400)	rpsT	867667..867915 (-)	249	WP_009881183.1	30S ribosomal protein S20	-
VKP53_RS04405 (VKP53_04405)	coaA	867969..868889 (-)	921	WP_010922353.1	type I pantothenate kinase	-
VKP53_RS04410 (VKP53_04410)	-	869157..869750 (+)	594	WP_010922352.1	class I SAM-dependent methyltransferase	-
VKP53_RS04415 (VKP53_04415)	-	870403..870792 (+)	390	WP_002984531.1	cytidine deaminase	-
VKP53_RS04420 (VKP53_04420)	-	870886..871938 (+)	1053	WP_012560741.1	BMP family lipoprotein	-

Sequence

Protein

• Length: 436 a.a.
• Molecular weight: 50121.67 Da
• Isoelectric Point: 9.2695

>NTDB_id=925220 VKP53_RS04395 WP_326675189.1 866232..867542(+) (ciaH) [Streptococcus pyogenes strain 6745-99]
MNKLKKEILSDNYNHFFHFFAVFTGIFVIMTIIILQIMRFGVYSSVDSSLVSVSNNASSYANRTMARISSFYFDTENNII
KALPDSDSSKLLGTPAANTDIILFSANGTILNAFDAFSNYQNFHLDKRRLGSIETTSLMNFYGQEEKYHTITVRVHIKNY
PAVAYMMAVVNVEQLDRANERYERIIIIVMSVFWLISILASIYLAKWSRKPILESYEKQKMFVENASHELRTPLAVLQNR
LESLFRKPNETILENSEHLASSLDEVRNMRILTTNLLNLARRDDGINPQWTHLDTDFFNAIFENYELVAKEYGKIFYFHN
QVNRSLRMDKALLKQLITILFDNAIKYTDKNGIIEIIVKTTDKNLLISVIDNGPGITDEEKKKIFDRFYRVDKARTRQTG
GFGLGLALAQQIVMSLKGNITVKDNDPKGSIFEVKL

Nucleotide

• Length: 1311 bp

>NTDB_id=925220 VKP53_RS04395 WP_326675189.1 866232..867542(+) (ciaH) [Streptococcus pyogenes strain 6745-99]
ATGAATAAATTAAAAAAAGAGATTTTATCAGATAACTATAACCACTTTTTTCATTTTTTTGCGGTTTTTACAGGTATTTT
TGTCATTATGACTATTATTATCTTACAGATTATGCGGTTTGGCGTTTATTCGTCAGTTGACAGTAGTTTAGTTTCTGTTA
GTAATAATGCAAGTAGCTATGCTAATCGTACGATGGCTAGAATATCTTCTTTTTACTTTGATACTGAAAATAACATTATT
AAGGCGCTGCCTGATTCAGATAGTTCTAAGTTATTAGGAACGCCTGCAGCTAATACAGATATCATTTTGTTTAGTGCTAA
TGGAACAATTTTAAATGCTTTTGATGCGTTTTCTAACTATCAAAATTTTCATTTAGATAAACGCCGGTTGGGGAGTATTG
AAACCACCAGTTTAATGAATTTTTATGGACAAGAAGAAAAATACCATACGATAACTGTAAGGGTTCATATCAAAAATTAT
CCTGCAGTTGCCTATATGATGGCAGTAGTAAATGTGGAACAATTAGACCGCGCTAATGAACGTTATGAGCGCATTATTAT
TATAGTTATGAGTGTTTTTTGGCTAATTTCTATTTTAGCAAGTATTTATTTAGCCAAGTGGAGCAGAAAACCTATTTTAG
AAAGCTATGAAAAACAAAAAATGTTTGTTGAAAATGCTAGTCATGAATTAAGGACCCCTTTGGCGGTCTTACAGAATCGT
CTGGAATCGCTTTTTCGTAAGCCCAACGAAACGATATTAGAAAATAGTGAGCATCTCGCTTCTAGTTTAGACGAGGTTCG
CAACATGCGCATCTTAACAACTAATTTATTAAATTTAGCAAGACGAGATGATGGCATTAATCCACAGTGGACTCATTTAG
ATACAGATTTTTTTAATGCTATTTTTGAGAATTATGAACTAGTTGCTAAAGAATATGGAAAAATATTTTATTTTCATAAC
CAAGTCAATAGATCGTTAAGAATGGATAAGGCTTTACTAAAACAATTAATAACGATTTTATTTGACAATGCTATTAAATA
TACAGATAAAAATGGTATTATTGAAATTATAGTGAAAACAACGGACAAAAATTTATTGATTTCTGTTATTGATAATGGTC
CAGGGATAACAGATGAAGAAAAGAAAAAGATTTTTGATCGTTTTTATCGAGTTGACAAAGCTAGAACACGGCAAACAGGT
GGATTTGGCTTGGGGTTGGCTTTAGCTCAGCAAATCGTGATGTCTTTAAAAGGAAATATTACAGTAAAGGATAATGATCC
TAAAGGTAGTATTTTTGAAGTCAAACTATAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (329-436)

• His Kinase A (phospho-acceptor) domain (HisKA) (220-285)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaH	Streptococcus mutans UA159	57.895	100	0.58
ciaH	Streptococcus pneumoniae Rx1	51.37	100	0.516
ciaH	Streptococcus pneumoniae D39	51.37	100	0.516
ciaH	Streptococcus pneumoniae R6	51.37	100	0.516
ciaH	Streptococcus pneumoniae TIGR4	51.37	100	0.516