Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD/comD2   Type   Regulator
Locus tag   U0448_RS05335 Genome accession   NZ_CP139860
Coordinates   1046343..1047668 (-) Length   441 a.a.
NCBI ID   WP_001842237.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain 21011     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 1041343..1052668
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  U0448_RS05310 - 1043070..1044681 (-) 1612 Protein_1005 YhgE/Pip family protein -
  U0448_RS05315 - 1044809..1045351 (+) 543 WP_001158263.1 TetR/AcrR family transcriptional regulator -
  U0448_RS05330 comE 1045594..1046346 (-) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  U0448_RS05335 comD/comD2 1046343..1047668 (-) 1326 WP_001842237.1 competence system sensor histidine kinase ComD Regulator
  U0448_RS05340 comC/comC2 1047689..1047814 (-) 126 WP_000799686.1 competence-stimulating peptide ComC Regulator
  U0448_RS05350 rlmH 1048096..1048575 (-) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  U0448_RS05355 htrA 1048758..1049939 (+) 1182 WP_000681601.1 S1C family serine protease Regulator
  U0448_RS05360 spo0J 1049997..1050755 (+) 759 WP_000410385.1 ParB/RepB/Spo0J family partition protein Regulator
  U0448_RS05365 dnaA 1050968..1052329 (+) 1362 WP_000660615.1 chromosomal replication initiator protein DnaA -

Sequence

Protein


Download         Length: 441 a.a.        Molecular weight: 51441.05 Da        Isoelectric Point: 7.5816

>NTDB_id=911348 U0448_RS05335 WP_001842237.1 1046343..1047668(-) (comD/comD2) [Streptococcus pneumoniae strain 21011]
MDLLGFGTVIVHFLIISHSYRLICKGRINRKELYVFGAYTLLTEIVLEFSFYLLYLDKIGIERFLFPLGLYSYFRWMKQY
ERDRGLFLSLLLSLLYESTHNFLSVTFSSITGDNFVLQYHFPFFFVVTVLTYFVTLKIIYYFHLELAYFDKDYLYPFLKK
VFFALLLLHIVSFVSDMVSTIKHLNSFGSILSSIVFISLLLTFFAMNSHKVQMEKEIALKQKKFEQKHLQNYTDEIVGLY
NEIRGFRHDYAGMLVSMQMAIDSGNLQEIDRIYNEVLVKANHKLRSDKYTYFDLNNIEDSALRSLVAQSIVYARNNGVEF
TLEVKDTITKLPIELLDLVRIMSVLLNNAVEGSADSYKKQMEVAVIKMETETVMVIQNSCKMTMTPSGDLFALGFSTKGR
NRGVGLNNVKELLDKYNNIILETEMEGSTFRQIIRFKREFE

Nucleotide


Download         Length: 1326 bp        

>NTDB_id=911348 U0448_RS05335 WP_001842237.1 1046343..1047668(-) (comD/comD2) [Streptococcus pneumoniae strain 21011]
ATGGATTTACTTGGATTTGGGACAGTTATTGTTCATTTTTTAATTATTAGTCACAGTTACCGTTTAATTTGTAAAGGTCG
AATAAATAGAAAAGAATTATACGTTTTTGGTGCTTATACATTACTAACTGAAATAGTACTTGAATTTTCCTTTTATCTTC
TATATTTAGATAAAATAGGGATTGAAAGATTTTTATTTCCTTTGGGCTTATATTCCTATTTTCGATGGATGAAACAGTAT
GAGAGGGATAGAGGACTATTCCTAAGTTTACTACTATCTCTTTTATATGAGAGCACTCATAACTTTCTGTCCGTAACTTT
CTCCTCTATAACAGGAGATAATTTTGTTTTACAATATCATTTCCCATTCTTTTTCGTTGTGACGGTGTTAACCTATTTTG
TTACATTAAAAATCATTTATTATTTCCATTTGGAACTAGCCTATTTTGACAAGGACTACCTTTATCCTTTCTTGAAAAAA
GTATTTTTTGCTTTACTATTGCTACATATTGTATCTTTCGTTTCAGATATGGTAAGTACGATTAAACATTTGAATAGTTT
TGGAAGTATTTTGTCATCTATTGTCTTTATCTCTCTCCTTTTGACCTTCTTTGCAATGAATTCTCATAAAGTTCAAATGG
AGAAAGAGATTGCTTTGAAGCAGAAGAAATTTGAACAGAAACATTTACAGAATTACACAGATGAAATTGTTGGTCTGTAT
AATGAAATCCGTGGTTTTCGACATGATTATGCTGGAATGCTTGTCAGCATGCAGATGGCAATTGACAGTGGTAATTTACA
GGAAATTGACAGAATTTACAATGAAGTTTTAGTCAAAGCAAATCATAAATTGCGTTCAGATAAGTACACTTACTTTGATT
TGAACAACATAGAAGACTCAGCTTTACGAAGTTTGGTTGCTCAGTCAATTGTCTATGCTCGAAATAATGGTGTAGAGTTT
ACACTGGAAGTAAAAGATACGATTACCAAGCTTCCAATTGAACTATTGGATTTGGTTCGTATCATGAGCGTTTTATTGAA
TAATGCTGTCGAAGGATCGGCTGATAGCTATAAAAAGCAGATGGAAGTAGCAGTTATTAAGATGGAAACTGAAACAGTTA
TGGTGATTCAGAATTCATGTAAAATGACGATGACTCCTTCAGGAGATCTATTTGCCTTAGGATTCTCCACTAAGGGAAGA
AATCGCGGAGTCGGATTAAATAATGTGAAAGAACTACTAGATAAGTACAACAATATTATTTTAGAAACAGAGATGGAAGG
CAGTACATTTAGACAAATCATTAGATTTAAGAGGGAATTTGAATGA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(334-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD/comD2 Streptococcus pneumoniae TIGR4

99.546

100

0.995
  comD/comD1 Streptococcus pneumoniae Rx1

96.825

100

0.968
  comD/comD1 Streptococcus pneumoniae D39

96.825

100

0.968
  comD/comD1 Streptococcus pneumoniae R6

96.825

100

0.968
  comD Streptococcus mitis SK321

92.063

100

0.921
  comD Streptococcus mitis NCTC 12261

86.621

100

0.866
  comD/comD2 Streptococcus gordonii strain NCTC7865

49.202

85.261

0.42
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

49.465

84.807

0.419