Detailed information NTG0896721

Bioinformatically predicted

Overview

• Name: ciaH
• Type: Regulator
• Locus tag: ABC810_RS07505
• Genome accession: NZ_CP155532
• Coordinates: 1477157..1478491 (-)
• Length: 444 a.a.
• NCBI ID: WP_000491790.1
• Uniprot ID: Q7B3G0
• Organism: Streptococcus pneumoniae strain SP264
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 1472157..1483491

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ABC810_RS07490 (ABC810_07480)	-	1473117..1475567 (-)	2451	WP_000848695.1	bifunctional DnaQ family exonuclease/ATP-dependent helicase	-
ABC810_RS07495 (ABC810_07485)	-	1475767..1476696 (-)	930	WP_000411854.1	peptidase U32 family protein	-
ABC810_RS07500 (ABC810_07490)	-	1476836..1477123 (+)	288	WP_001145225.1	DUF3270 domain-containing protein	-
ABC810_RS07505 (ABC810_07495)	ciaH	1477157..1478491 (-)	1335	WP_000491790.1	two-component system sensor histidine kinase CiaH	Regulator
ABC810_RS07510 (ABC810_07500)	ciaR	1478481..1479155 (-)	675	WP_000590619.1	two-component system response regulator CiaR	Regulator
ABC810_RS07515 (ABC810_07505)	-	1479373..1480629 (+)	1257	WP_000436228.1	ISL3-like element IS1167A family transposase	-
ABC810_RS07520 (ABC810_07510)	-	1480687..1483233 (-)	2547	WP_001149115.1	M1 family metallopeptidase	-

Sequence

Protein

• Length: 444 a.a.
• Molecular weight: 50673.39 Da
• Isoelectric Point: 9.1661

>NTDB_id=896721 ABC810_RS07505 WP_000491790.1 1477157..1478491(-) (ciaH) [Streptococcus pneumoniae strain SP264]
MFSKLKKTWYADDFSYFIRNFGVFTLIFSTMTLIILQVMHSSLYTSVDDKLHGLSENPQAVIQLAINRATEEIKDLENAR
ADASKVEIKPNVSSNTEVILFDKDFTQLLSGNRFLGLDKIKLEKKELGHIYQIQVFNSYGQEEIYRVILMETNISSVSTN
IKYAAVLINTSQLEQASQKHEQLIVVVMASFWILSLLASLYLARVSVRPLLESMQKQQSFVENASHELRTPLAVLQNRLE
TLFRKPEATIMDVSESIASSLEEVRNMRFLTTSLLNLARRDDGIKPELAEVPTSFFNTTFTNYEMIASENNRVFRFENRI
HRTIVTDQLLLKQLMTILFDNAVKYTEEDGEIDFLISATDRNLYLLVSDNGIGISTEDKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDALKGTVTVKDNKPKGTIFEVKIAIQTPSKKKK

Nucleotide

• Length: 1335 bp

>NTDB_id=896721 ABC810_RS07505 WP_000491790.1 1477157..1478491(-) (ciaH) [Streptococcus pneumoniae strain SP264]
ATGTTCAGTAAACTTAAAAAAACATGGTATGCGGATGACTTTAGTTATTTTATCCGCAACTTCGGTGTCTTCACCCTGAT
TTTTTCTACAATGACTCTGATTATTTTACAAGTCATGCATTCGAGTCTTTATACTTCGGTGGACGATAAGCTTCATGGAC
TGAGTGAAAATCCTCAAGCAGTTATTCAGCTGGCTATAAATAGGGCAACAGAAGAGATTAAAGATTTAGAAAATGCTAGG
GCGGACGCTAGTAAAGTAGAAATAAAACCTAATGTCAGTTCCAATACGGAAGTCATTCTCTTTGATAAAGACTTTACTCA
ACTTCTTTCTGGAAATCGATTTTTGGGCTTGGATAAGATTAAGTTAGAAAAGAAAGAACTAGGACATATCTACCAGATTC
AGGTTTTTAATAGCTATGGGCAGGAAGAAATCTATCGTGTGATTTTGATGGAGACCAATATTAGTTCGGTTTCAACCAAT
ATCAAGTATGCTGCTGTCTTGATTAATACCAGTCAGTTGGAGCAGGCTAGTCAAAAGCATGAGCAATTGATTGTGGTCGT
GATGGCTAGTTTCTGGATTTTGTCTTTACTTGCCAGTCTCTATCTAGCTAGGGTCAGTGTTAGGCCCCTGCTTGAGAGTA
TGCAGAAGCAACAGTCTTTTGTGGAAAATGCCAGTCATGAGTTACGAACTCCACTCGCAGTTTTGCAAAATCGCTTAGAG
ACCCTTTTTCGTAAGCCAGAAGCTACCATTATGGATGTGAGCGAAAGCATTGCATCGAGTTTGGAAGAAGTCCGAAATAT
GCGTTTTTTAACGACAAGCTTGCTGAACTTAGCTCGGAGAGATGATGGGATTAAGCCGGAGCTTGCAGAAGTTCCAACTA
GCTTTTTTAATACAACTTTCACAAACTATGAGATGATTGCTTCGGAAAATAATCGTGTCTTCCGTTTTGAAAATCGTATC
CATCGAACAATTGTCACAGATCAGCTTCTTCTGAAACAACTGATGACCATTCTTTTCGATAATGCCGTCAAGTATACTGA
GGAGGATGGTGAAATTGATTTTCTTATCTCGGCGACCGATCGCAATCTTTATTTACTTGTTTCTGATAATGGAATCGGTA
TTTCGACAGAAGATAAAAAGAAAATTTTTGACCGTTTTTATCGAGTAGACAAAGCTAGAACCCGGCAAAAAGGTGGTTTT
GGTTTAGGATTATCCCTAGCCAAGCAAATTGTAGATGCTCTAAAAGGAACTGTTACTGTCAAAGATAATAAACCCAAGGG
AACAATCTTTGAAGTGAAGATTGCCATTCAGACACCATCTAAAAAGAAAAAATAA

Domains

Predicted by InterProScan.

• His Kinase A (phospho-acceptor) domain (HisKA) (217-283)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (327-434)

3D structure

• AlphaFold DB: Q7B3G0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaH	Streptococcus pneumoniae Rx1	100	100	1
ciaH	Streptococcus pneumoniae D39	100	100	1
ciaH	Streptococcus pneumoniae R6	100	100	1
ciaH	Streptococcus pneumoniae TIGR4	100	100	1
ciaH	Streptococcus mutans UA159	55.632	97.973	0.545