Detailed information NTG0896139

Bioinformatically predicted

Overview

• Name: ciaH
• Type: Regulator
• Locus tag: R4707_RS09750
• Genome accession: NZ_CP137113
• Coordinates: 1851175..1852509 (+)
• Length: 444 a.a.
• NCBI ID: WP_000491790.1
• Uniprot ID: Q7B3G0
• Organism: Streptococcus pneumoniae strain ZGX
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 1846175..1857509

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R4707_RS09730	-	1846455..1847324 (+)	870	WP_001245821.1	putative PEP-binding protein	-
R4707_RS09735	-	1847299..1847733 (+)	435	WP_081543064.1	ASCH domain-containing protein	-
R4707_RS09740	-	1847856..1850402 (+)	2547	WP_001149118.1	M1 family metallopeptidase	-
R4707_RS09745	ciaR	1850511..1851185 (+)	675	WP_000590640.1	two-component system response regulator CiaR	Regulator
R4707_RS09750	ciaH	1851175..1852509 (+)	1335	WP_000491790.1	two-component system sensor histidine kinase CiaH	Regulator
R4707_RS09755	-	1852543..1852830 (-)	288	WP_001145226.1	DUF3270 domain-containing protein	-
R4707_RS09760	-	1852970..1853899 (+)	930	WP_000411851.1	peptidase U32 family protein	-
R4707_RS09765	-	1853974..1855280 (-)	1307	Protein_1885	transposase	-

Sequence

Protein

• Length: 444 a.a.
• Molecular weight: 50673.39 Da
• Isoelectric Point: 9.1661

>NTDB_id=896139 R4707_RS09750 WP_000491790.1 1851175..1852509(+) (ciaH) [Streptococcus pneumoniae strain ZGX]
MFSKLKKTWYADDFSYFIRNFGVFTLIFSTMTLIILQVMHSSLYTSVDDKLHGLSENPQAVIQLAINRATEEIKDLENAR
ADASKVEIKPNVSSNTEVILFDKDFTQLLSGNRFLGLDKIKLEKKELGHIYQIQVFNSYGQEEIYRVILMETNISSVSTN
IKYAAVLINTSQLEQASQKHEQLIVVVMASFWILSLLASLYLARVSVRPLLESMQKQQSFVENASHELRTPLAVLQNRLE
TLFRKPEATIMDVSESIASSLEEVRNMRFLTTSLLNLARRDDGIKPELAEVPTSFFNTTFTNYEMIASENNRVFRFENRI
HRTIVTDQLLLKQLMTILFDNAVKYTEEDGEIDFLISATDRNLYLLVSDNGIGISTEDKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDALKGTVTVKDNKPKGTIFEVKIAIQTPSKKKK

Nucleotide

• Length: 1335 bp

>NTDB_id=896139 R4707_RS09750 WP_000491790.1 1851175..1852509(+) (ciaH) [Streptococcus pneumoniae strain ZGX]
ATGTTCAGTAAACTTAAAAAAACATGGTATGCGGATGACTTTAGTTATTTTATCCGCAACTTCGGTGTCTTCACCCTGAT
TTTTTCTACAATGACTCTGATTATTTTACAAGTCATGCATTCGAGTCTTTATACTTCGGTGGACGATAAGCTTCATGGAC
TGAGTGAAAATCCTCAAGCAGTTATTCAGCTGGCTATAAATAGGGCAACAGAAGAGATTAAAGATTTAGAAAATGCTAGG
GCGGACGCTAGTAAAGTAGAAATAAAACCTAATGTCAGTTCCAATACGGAAGTCATTCTCTTTGATAAAGACTTTACTCA
ACTTCTTTCTGGAAATCGATTTTTGGGCTTGGATAAGATTAAGTTAGAAAAGAAAGAACTAGGACATATCTACCAGATTC
AGGTTTTTAATAGCTATGGGCAGGAAGAAATCTATCGTGTGATTTTGATGGAGACCAATATTAGTTCGGTTTCAACCAAT
ATCAAGTATGCTGCTGTCTTGATTAATACCAGTCAGTTGGAGCAGGCTAGTCAAAAGCATGAGCAATTGATTGTGGTCGT
GATGGCTAGTTTCTGGATTTTGTCTTTACTTGCCAGTCTCTATCTAGCTAGGGTCAGTGTTAGGCCCCTGCTTGAGAGTA
TGCAGAAGCAACAGTCTTTTGTGGAAAATGCCAGTCATGAGTTACGAACTCCACTCGCAGTTTTGCAAAATCGCTTAGAG
ACCCTTTTTCGTAAGCCAGAAGCTACCATTATGGATGTGAGCGAAAGCATTGCATCGAGTTTGGAAGAAGTCCGAAATAT
GCGTTTTTTAACGACAAGCTTGCTGAACTTAGCTCGGAGAGATGATGGGATTAAGCCGGAGCTTGCAGAAGTTCCAACTA
GCTTTTTTAATACAACTTTCACAAACTACGAGATGATTGCTTCGGAAAATAATCGTGTCTTCCGTTTTGAAAATCGTATC
CATCGAACAATTGTCACAGATCAGCTTCTTCTGAAACAACTGATGACCATTCTTTTCGATAATGCCGTCAAGTATACTGA
GGAGGATGGTGAAATTGATTTTCTTATCTCGGCGACCGATCGCAATCTTTATTTACTTGTTTCTGATAATGGAATCGGTA
TTTCGACAGAAGATAAAAAGAAAATTTTTGACCGTTTTTATCGAGTAGACAAAGCTAGAACCCGGCAAAAAGGTGGTTTT
GGTTTAGGATTATCCCTAGCCAAGCAAATTGTAGATGCTCTAAAAGGAACTGTTACTGTCAAAGATAATAAACCCAAGGG
AACAATCTTTGAAGTGAAGATTGCCATTCAGACACCATCTAAAAAGAAAAAATAA

Domains

Predicted by InterproScan.

• His Kinase A (phospho-acceptor) domain (HisKA) (217-283)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (327-434)

3D structure

• AlphaFold DB: Q7B3G0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaH	Streptococcus pneumoniae Rx1	100	100	1
ciaH	Streptococcus pneumoniae D39	100	100	1
ciaH	Streptococcus pneumoniae R6	100	100	1
ciaH	Streptococcus pneumoniae TIGR4	100	100	1
ciaH	Streptococcus mutans UA159	55.632	97.973	0.545