Detailed information NTG0895920

Bioinformatically predicted

Overview

• Name: ciaH
• Type: Regulator
• Locus tag: R4706_RS01675
• Genome accession: NZ_CP137111
• Coordinates: 343233..344567 (-)
• Length: 444 a.a.
• NCBI ID: WP_000491790.1
• Uniprot ID: Q7B3G0
• Organism: Streptococcus pneumoniae strain 17023
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 338233..349567

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R4706_RS01660	-	339193..341643 (-)	2451	WP_044727728.1	bifunctional DnaQ family exonuclease/ATP-dependent helicase	-
R4706_RS01665	-	341843..342772 (-)	930	WP_044727729.1	peptidase U32 family protein	-
R4706_RS01670	-	342912..343199 (+)	288	WP_001145225.1	DUF3270 domain-containing protein	-
R4706_RS01675	ciaH	343233..344567 (-)	1335	WP_000491790.1	two-component system sensor histidine kinase CiaH	Regulator
R4706_RS01680	ciaR	344557..345231 (-)	675	WP_000590640.1	two-component system response regulator CiaR	Regulator
R4706_RS01685	-	345340..347886 (-)	2547	WP_001149118.1	M1 family metallopeptidase	-
R4706_RS01690	-	348009..348449 (-)	441	WP_000612882.1	ASCH domain-containing protein	-
R4706_RS01695	-	348424..349293 (-)	870	WP_001245821.1	putative PEP-binding protein	-

Sequence

Protein

• Length: 444 a.a.
• Molecular weight: 50673.39 Da
• Isoelectric Point: 9.1661

>NTDB_id=895920 R4706_RS01675 WP_000491790.1 343233..344567(-) (ciaH) [Streptococcus pneumoniae strain 17023]
MFSKLKKTWYADDFSYFIRNFGVFTLIFSTMTLIILQVMHSSLYTSVDDKLHGLSENPQAVIQLAINRATEEIKDLENAR
ADASKVEIKPNVSSNTEVILFDKDFTQLLSGNRFLGLDKIKLEKKELGHIYQIQVFNSYGQEEIYRVILMETNISSVSTN
IKYAAVLINTSQLEQASQKHEQLIVVVMASFWILSLLASLYLARVSVRPLLESMQKQQSFVENASHELRTPLAVLQNRLE
TLFRKPEATIMDVSESIASSLEEVRNMRFLTTSLLNLARRDDGIKPELAEVPTSFFNTTFTNYEMIASENNRVFRFENRI
HRTIVTDQLLLKQLMTILFDNAVKYTEEDGEIDFLISATDRNLYLLVSDNGIGISTEDKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDALKGTVTVKDNKPKGTIFEVKIAIQTPSKKKK

Nucleotide

• Length: 1335 bp

>NTDB_id=895920 R4706_RS01675 WP_000491790.1 343233..344567(-) (ciaH) [Streptococcus pneumoniae strain 17023]
ATGTTCAGTAAACTTAAAAAAACATGGTATGCGGATGACTTTAGTTATTTTATCCGCAACTTCGGTGTCTTCACCCTGAT
TTTTTCTACAATGACTCTGATTATTTTACAAGTCATGCATTCGAGTCTTTATACTTCGGTGGACGATAAGCTTCATGGAC
TGAGTGAAAATCCTCAAGCAGTTATTCAGCTGGCTATAAATAGGGCAACAGAAGAGATTAAAGATTTAGAAAATGCTAGG
GCGGACGCTAGTAAAGTAGAAATAAAACCTAATGTCAGTTCCAATACGGAAGTCATTCTCTTTGATAAAGACTTTACTCA
ACTTCTTTCTGGAAATCGATTTTTGGGCTTGGATAAGATTAAGTTAGAAAAGAAAGAACTAGGACATATCTACCAGATTC
AGGTTTTTAATAGCTATGGGCAGGAAGAAATCTATCGTGTGATTTTGATGGAGACCAATATTAGTTCGGTTTCAACCAAT
ATCAAGTATGCTGCTGTCTTGATTAATACCAGTCAGTTGGAGCAGGCTAGTCAAAAGCATGAGCAATTGATTGTGGTCGT
GATGGCTAGTTTCTGGATTTTGTCTTTACTTGCCAGTCTCTATCTAGCTAGGGTCAGTGTTAGGCCCCTGCTTGAGAGTA
TGCAGAAGCAACAGTCTTTTGTGGAAAATGCCAGTCATGAGTTACGAACTCCACTCGCAGTTTTGCAAAATCGCTTAGAG
ACCCTTTTTCGTAAGCCAGAAGCTACCATTATGGATGTGAGCGAAAGCATTGCATCGAGTTTGGAAGAAGTCCGAAATAT
GCGTTTTTTAACGACAAGCTTGCTGAACTTAGCTCGGAGAGATGATGGGATTAAGCCGGAGCTTGCAGAAGTTCCAACTA
GCTTTTTTAATACAACTTTCACAAACTACGAGATGATTGCTTCGGAAAATAATCGTGTCTTCCGTTTTGAAAATCGTATC
CATCGAACAATTGTCACAGATCAGCTTCTTCTGAAACAACTGATGACCATTCTTTTCGATAATGCCGTCAAGTATACTGA
GGAGGATGGTGAAATTGATTTTCTTATCTCGGCGACCGATCGCAATCTTTATTTACTTGTTTCTGATAATGGAATCGGTA
TTTCGACAGAAGATAAAAAGAAAATTTTTGACCGTTTTTATCGAGTAGACAAAGCTAGAACCCGGCAAAAAGGTGGTTTT
GGTTTAGGATTATCCCTAGCCAAGCAAATTGTAGATGCTCTAAAAGGAACTGTTACTGTCAAAGATAATAAACCCAAGGG
AACAATCTTTGAAGTGAAGATTGCCATTCAGACACCATCTAAAAAGAAAAAATAA

Domains

Predicted by InterproScan.

• His Kinase A (phospho-acceptor) domain (HisKA) (217-283)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (327-434)

3D structure

• AlphaFold DB: Q7B3G0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaH	Streptococcus pneumoniae Rx1	100	100	1
ciaH	Streptococcus pneumoniae D39	100	100	1
ciaH	Streptococcus pneumoniae R6	100	100	1
ciaH	Streptococcus pneumoniae TIGR4	100	100	1
ciaH	Streptococcus mutans UA159	55.632	97.973	0.545