Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD/comD1   Type   Regulator
Locus tag   R4704_RS05605 Genome accession   NZ_CP137109
Coordinates   1070479..1071804 (-) Length   441 a.a.
NCBI ID   WP_033705078.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain 11012     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 1065479..1076804
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4704_RS05580 - 1067163..1068766 (-) 1604 Protein_1062 YhgE/Pip family protein -
  R4704_RS05585 - 1068945..1069487 (+) 543 WP_033705079.1 TetR/AcrR family transcriptional regulator -
  R4704_RS05600 comE 1069730..1070482 (-) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  R4704_RS05605 comD/comD1 1070479..1071804 (-) 1326 WP_033705078.1 competence system sensor histidine kinase ComD Regulator
  R4704_RS05610 comC/comC1 1071825..1071950 (-) 126 WP_000799689.1 competence-stimulating peptide ComC Regulator
  R4704_RS05620 rlmH 1072232..1072711 (-) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  R4704_RS05625 htrA 1072894..1074075 (+) 1182 WP_000681597.1 S1C family serine protease Regulator
  R4704_RS05630 spo0J 1074133..1074891 (+) 759 WP_000410380.1 ParB/RepB/Spo0J family partition protein Regulator
  R4704_RS05635 dnaA 1075104..1076465 (+) 1362 WP_000660615.1 chromosomal replication initiator protein DnaA -

Sequence

Protein


Download         Length: 441 a.a.        Molecular weight: 51314.81 Da        Isoelectric Point: 6.9341

>NTDB_id=895806 R4704_RS05605 WP_033705078.1 1070479..1071804(-) (comD/comD1) [Streptococcus pneumoniae strain 11012]
MDLFGFGTVIVHFLIISHSYHLICKGQINRKELFVFGAYTLLTEIVFDFPLYILYLDGLGIERFLFPLGLYSYFRWIKQY
ERDRGLFLSLLLSLLYESTHNFLSVTFSSITGDNFVLQYHFPFFFVVTVLTYFVTLKIIYYFHLELAYFDKDYLYPFLKK
VFFALLLLHIISFVSDMVSTIKHLNSFGSILSSIVFISLLLTFFAMNSHKVQMEKEIALKQKKFEQKHLQNYTDEIVGLY
NEIRGFRHDYAGMLVSMQMAIDSGNLQEIDRIYNEVLVKANHKLRSDKYTYFDLNNIEDSALRSLVAQSIVYARNNGVEF
TLEVKDTITKLPIELLDLVRIMSVLLNNAVEGSADSYKKQMEVAVIKMETETVIVIQNSCKMTMTPSGDLFALGFSTKGR
NRGVGLNNVKELLDKYNNIILETEMEGSTFRQIIRFKREFE

Nucleotide


Download         Length: 1326 bp        

>NTDB_id=895806 R4704_RS05605 WP_033705078.1 1070479..1071804(-) (comD/comD1) [Streptococcus pneumoniae strain 11012]
ATGGATTTATTTGGATTTGGGACGGTTATTGTTCATTTTTTAATTATTAGTCACAGTTACCATTTAATTTGTAAAGGTCA
AATAAATAGAAAAGAATTATTCGTTTTTGGTGCTTATACATTACTAACAGAAATAGTATTTGATTTTCCCTTATATATTC
TATATTTAGATGGGTTAGGGATTGAAAGATTTTTATTTCCTTTGGGCTTATATTCCTATTTTCGATGGATAAAACAGTAT
GAGAGGGATAGAGGACTATTCCTAAGTTTACTACTATCTCTTTTATATGAGAGCACTCATAACTTTCTGTCCGTAACTTT
CTCCTCTATAACAGGAGATAATTTTGTTTTACAATATCATTTCCCATTCTTTTTCGTTGTGACGGTGTTAACCTATTTTG
TTACATTAAAAATCATTTACTATTTCCATTTGGAACTAGCCTATTTTGACAAGGACTACCTTTATCCTTTCTTGAAAAAA
GTATTTTTTGCTTTACTATTGCTACATATTATATCTTTCGTTTCAGATATGGTAAGTACGATTAAACATTTGAATAGTTT
TGGAAGTATTTTGTCATCTATTGTCTTTATCTCTCTCCTTTTGACCTTCTTTGCAATGAATTCTCATAAAGTTCAAATGG
AGAAAGAGATTGCTTTGAAGCAGAAGAAATTTGAACAGAAACATTTACAGAATTACACAGATGAAATTGTTGGTCTGTAT
AATGAAATCCGTGGTTTTCGACATGATTATGCTGGAATGCTTGTCAGCATGCAGATGGCAATTGACAGTGGTAATTTACA
GGAAATTGACAGAATTTACAATGAAGTTTTAGTCAAAGCAAATCATAAATTGCGTTCAGATAAGTACACTTACTTTGATT
TGAACAACATAGAAGACTCAGCTTTACGAAGTTTGGTTGCTCAGTCAATTGTCTATGCTCGAAATAATGGTGTAGAGTTT
ACACTGGAAGTAAAAGATACGATTACCAAGCTTCCAATTGAACTATTGGATTTGGTTCGTATTATGAGCGTTTTATTGAA
TAATGCTGTCGAAGGATCGGCTGATAGCTATAAAAAGCAGATGGAAGTAGCAGTTATTAAGATGGAAACTGAAACAGTTA
TTGTGATTCAGAATTCATGTAAAATGACGATGACTCCTTCAGGAGATCTATTTGCCTTAGGATTCTCCACTAAGGGAAGA
AATCGCGGAGTCGGATTAAATAATGTGAAAGAACTACTAGATAAGTACAACAATATTATTTTAGAAACAGAGATGGAAGG
CAGTACATTTAGACAAATCATTAGATTTAAGAGGGAATTTGAATGA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(334-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD/comD1 Streptococcus pneumoniae Rx1

99.093

100

0.991
  comD/comD1 Streptococcus pneumoniae D39

99.093

100

0.991
  comD/comD1 Streptococcus pneumoniae R6

99.093

100

0.991
  comD/comD2 Streptococcus pneumoniae TIGR4

96.825

100

0.968
  comD Streptococcus mitis SK321

92.517

100

0.925
  comD Streptococcus mitis NCTC 12261

86.621

100

0.866
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

49.468

85.261

0.422
  comD/comD2 Streptococcus gordonii strain NCTC7865

49.202

85.261

0.42