Detailed information NTG0895227

Bioinformatically predicted

Overview

• Name: ciaH
• Type: Regulator
• Locus tag: R4709_RS01535
• Genome accession: NZ_CP137102
• Coordinates: 306794..308128 (-)
• Length: 444 a.a.
• NCBI ID: WP_050233562.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain 16H3071-2
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 301794..313128

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R4709_RS01520	-	302754..305204 (-)	2451	WP_000848712.1	bifunctional DnaQ family exonuclease/ATP-dependent helicase	-
R4709_RS01525	-	305404..306333 (-)	930	WP_000411866.1	peptidase U32 family protein	-
R4709_RS01530	-	306473..306760 (+)	288	WP_001145225.1	DUF3270 domain-containing protein	-
R4709_RS01535	ciaH	306794..308128 (-)	1335	WP_050233562.1	two-component system sensor histidine kinase CiaH	Regulator
R4709_RS01540	ciaR	308118..308792 (-)	675	WP_000590640.1	two-component system response regulator CiaR	Regulator
R4709_RS01545	-	308901..311447 (-)	2547	WP_001149118.1	M1 family metallopeptidase	-
R4709_RS01550	-	311570..312010 (-)	441	WP_000612882.1	ASCH domain-containing protein	-
R4709_RS01555	-	311985..312854 (-)	870	WP_001245821.1	putative PEP-binding protein	-

Sequence

Protein

• Length: 444 a.a.
• Molecular weight: 50663.35 Da
• Isoelectric Point: 9.1661

>NTDB_id=895227 R4709_RS01535 WP_050233562.1 306794..308128(-) (ciaH) [Streptococcus pneumoniae strain 16H3071-2]
MFSKLKKTWYADDFSYFIRNFGVFTLIFSTMTLIILQVMHSSLYTSVDDKLHGLSENPQAVIQLAINRATEEIKDLENAR
ADASKVEIKPNVSSNTEVILFDKDFTQLLSGNRFLGLDKIKLEKKELGHIYQIQVFNSYGQEEIYRVILMETNISSVSTN
IKYAAVLINTSQLEQASQKHEQLIVVVMASFWILSLLASLYLARVSVRPLLESMQKQQSFVENASHELRTPLAVLQNRLE
TLFRKPEATIMDVSESIASSLEEVRNMRFLTTSLLNLARRDDGIKPELAEVPTSFFNTTFTNYEMIASENNRVFRFENRI
HRTIVTDQLLLKQLMTILFDNAVKYTEEDGEIDFLISATDRNLYLLVSDNGIGISTEDKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDALKGTVTVKDNKSKGTIFEVKIAIQTPSKKKK

Nucleotide

• Length: 1335 bp

>NTDB_id=895227 R4709_RS01535 WP_050233562.1 306794..308128(-) (ciaH) [Streptococcus pneumoniae strain 16H3071-2]
ATGTTCAGTAAACTTAAAAAAACATGGTATGCGGATGACTTTAGTTATTTTATCCGCAACTTCGGTGTCTTCACCCTGAT
TTTTTCTACAATGACTCTGATTATTTTACAAGTCATGCATTCGAGTCTTTATACTTCGGTGGACGATAAGCTTCATGGAC
TGAGTGAAAATCCTCAAGCAGTTATTCAGCTGGCTATAAATAGGGCAACAGAAGAGATTAAAGATTTAGAAAATGCTAGG
GCGGACGCTAGTAAAGTAGAAATAAAACCTAATGTCAGTTCCAATACGGAAGTCATTCTCTTTGATAAAGACTTTACTCA
ACTTCTTTCTGGAAATCGATTTTTGGGCTTGGATAAGATTAAGTTAGAAAAGAAAGAACTAGGACATATCTACCAGATTC
AGGTTTTTAATAGCTATGGGCAGGAAGAAATCTATCGTGTGATTTTGATGGAGACCAATATTAGTTCGGTTTCAACCAAT
ATCAAGTATGCTGCTGTCTTGATTAATACCAGTCAGTTGGAGCAGGCTAGTCAAAAGCATGAGCAATTGATTGTGGTCGT
GATGGCTAGTTTCTGGATTTTGTCTTTACTTGCCAGTCTCTATCTAGCTAGGGTCAGTGTTAGGCCCCTGCTTGAGAGTA
TGCAGAAGCAACAGTCTTTTGTGGAAAATGCCAGTCATGAGTTACGAACTCCACTCGCAGTTTTGCAAAATCGCTTAGAG
ACCCTTTTTCGTAAGCCAGAAGCTACCATTATGGATGTGAGCGAAAGCATTGCATCGAGTTTGGAAGAAGTCCGAAATAT
GCGTTTTTTAACGACAAGCTTGCTGAACTTAGCTCGGAGAGATGATGGGATTAAGCCGGAGCTTGCAGAAGTTCCAACTA
GCTTTTTTAATACAACTTTCACAAACTACGAGATGATTGCTTCGGAAAATAATCGTGTCTTCCGTTTTGAAAATCGTATC
CATCGAACAATTGTCACAGATCAGCTTCTTCTGAAACAACTGATGACCATTCTTTTCGATAATGCCGTCAAGTATACTGA
GGAGGATGGTGAAATTGATTTTCTTATCTCGGCGACCGATCGCAATCTTTATTTACTTGTTTCTGATAATGGAATCGGTA
TTTCGACAGAAGATAAAAAGAAAATTTTTGACCGTTTTTATCGAGTAGACAAGGCTAGAACCCGGCAAAAAGGTGGTTTT
GGTTTAGGATTATCCCTAGCCAAGCAAATTGTAGATGCTCTAAAAGGAACTGTTACTGTCAAAGATAATAAATCCAAGGG
AACAATCTTTGAAGTGAAGATTGCCATTCAGACACCATCTAAAAAGAAAAAATAA

Domains

Predicted by InterproScan.

• His Kinase A (phospho-acceptor) domain (HisKA) (217-283)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (327-434)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaH	Streptococcus pneumoniae Rx1	99.775	100	0.998
ciaH	Streptococcus pneumoniae D39	99.775	100	0.998
ciaH	Streptococcus pneumoniae R6	99.775	100	0.998
ciaH	Streptococcus pneumoniae TIGR4	99.775	100	0.998
ciaH	Streptococcus mutans UA159	55.402	97.973	0.543