Detailed information NTG0877764

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: RIM63_RS05070
• Genome accession: NZ_CP133952
• Coordinates: 1050833..1051570 (+)
• Length: 245 a.a.
• NCBI ID: WP_154803854.1
• Uniprot ID: A0A7Z8ZWL9
• Organism: Streptococcus equi subsp. zooepidemicus strain HT321
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1045833..1056570

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
RIM63_RS05040 (RIM63_05040)	-	1046273..1047178 (-)	906	WP_317585189.1	diacylglycerol kinase family lipid kinase	-
RIM63_RS05045 (RIM63_05045)	-	1047289..1047939 (-)	651	WP_317585191.1	hemolysin III family protein	-
RIM63_RS05050 (RIM63_05050)	-	1047923..1048378 (-)	456	WP_317585193.1	DUF1836 domain-containing protein	-
RIM63_RS05055 (RIM63_05055)	-	1048638..1049393 (+)	756	WP_317585195.1	class I SAM-dependent methyltransferase	-
RIM63_RS05060 (RIM63_05060)	-	1049421..1049759 (+)	339	WP_012677982.1	cupin domain-containing protein	-
RIM63_RS05065 (RIM63_05065)	-	1049761..1050066 (+)	306	WP_111692436.1	AraC family ligand binding domain-containing protein	-
RIM63_RS05070 (RIM63_05070)	comE/blpR	1050833..1051570 (+)	738	WP_154803854.1	response regulator transcription factor	Regulator
RIM63_RS05075 (RIM63_05075)	-	1051943..1052143 (+)	201	WP_043029696.1	hypothetical protein	-
RIM63_RS05080 (RIM63_05080)	-	1052210..1053064 (+)	855	WP_012515593.1	ABC transporter ATP-binding protein	-
RIM63_RS05085 (RIM63_05085)	-	1053070..1054233 (+)	1164	WP_024273178.1	ABC transporter permease subunit	-
RIM63_RS05090 (RIM63_05090)	-	1054495..1054725 (+)	231	WP_043038961.1	Blp family class II bacteriocin	-
RIM63_RS05095 (RIM63_05095)	-	1055518..1056369 (+)	852	WP_317585200.1	thioredoxin family protein	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28930.40 Da
• Isoelectric Point: 7.8796

>NTDB_id=877764 RIM63_RS05070 WP_154803854.1 1050833..1051570(+) (comE/blpR) [Streptococcus equi subsp. zooepidemicus strain HT321]
MNIFILEDDLGQQFRLEMKIQEILDKHHWTCDRFEVYGKPYQLLANVTERGRHQLFFLDIQIRNDEKKGLAVAREIRKRD
PYALIVFVTTHSELMPVSFRYQVSALDFIDKELSMKHFSDRIERAIIYAYEEQENVTSEGLFIFVTAKAQVQVPFSSLLF
IETSSTPHKLILHSQNERIEFYGFLSEVLKQDPRLVQCHRSYVINPYNVSFLDRDKRLLYFKNGQSCMVSRLKMKALEAS
IKALH

Nucleotide

• Length: 738 bp

>NTDB_id=877764 RIM63_RS05070 WP_154803854.1 1050833..1051570(+) (comE/blpR) [Streptococcus equi subsp. zooepidemicus strain HT321]
ATGAATATTTTTATTCTCGAAGATGATCTAGGCCAACAGTTTAGGCTTGAGATGAAGATTCAAGAGATATTGGATAAGCA
TCACTGGACTTGTGATCGTTTTGAAGTTTATGGAAAGCCCTACCAGCTTCTGGCAAATGTTACAGAGAGAGGCAGGCATC
AGCTTTTCTTTCTCGATATTCAAATTCGAAATGATGAGAAAAAGGGCTTAGCTGTTGCTCGTGAGATCAGAAAGCGTGAC
CCTTATGCCCTCATTGTTTTTGTCACCACACATTCTGAGCTTATGCCAGTTTCTTTTCGTTATCAGGTGTCTGCTCTAGA
TTTTATCGATAAGGAATTGTCAATGAAACATTTCTCAGATAGGATTGAAAGAGCCATTATATATGCTTATGAAGAGCAAG
AAAATGTAACCTCAGAGGGCTTATTTATTTTTGTAACGGCTAAGGCTCAGGTGCAGGTTCCTTTTTCAAGCCTATTGTTC
ATTGAGACCTCTAGTACTCCTCACAAGTTGATTTTGCATTCTCAAAACGAGCGAATAGAATTTTATGGCTTTCTTTCAGA
GGTTCTTAAGCAAGATCCCAGACTAGTCCAATGTCATCGTTCTTATGTTATCAATCCTTACAATGTTTCGTTTCTTGATC
GTGATAAGCGTTTACTCTATTTCAAGAATGGGCAGTCTTGCATGGTTTCAAGACTAAAAATGAAAGCACTTGAGGCGTCT
ATTAAGGCTTTGCATTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-240)

• Response regulator receiver domain (Response_reg) (18-122)

3D structure

• AlphaFold DB: A0A7Z8ZWL9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.132	98.776	0.535
comE/comE1	Streptococcus equinus JB1	45.455	98.776	0.449
comE/comE2	Streptococcus equinus JB1	37.295	99.592	0.371