Detailed information NTG0863883

Bioinformatically predicted

Overview

• Name: micA
• Type: Regulator
• Locus tag: Q7626_RS05490
• Genome accession: NZ_CP131707
• Coordinates: 1100454..1101158 (-)
• Length: 234 a.a.
• NCBI ID: WP_000722076.1
• Uniprot ID: Q9S1K0
• Organism: Streptococcus pneumoniae strain 2018C08-270
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1095454..1106158

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
Q7626_RS05460 (Q7626_05455)	-	1095647..1096633 (+)	987	WP_000204727.1	L-lactate dehydrogenase	-
Q7626_RS05465 (Q7626_05460)	-	1096922..1097665 (-)	744	WP_001037000.1	potassium channel family protein	-
Q7626_RS05470 (Q7626_05465)	-	1097712..1097966 (-)	255	WP_001809704.1	type II toxin-antitoxin system RelE/ParE family toxin	-
Q7626_RS05475 (Q7626_05470)	-	1097968..1098210 (-)	243	WP_000208080.1	DUF6290 family protein	-
Q7626_RS05480 (Q7626_05475)	vicX	1098301..1099110 (-)	810	WP_001289493.1	MBL fold metallo-hydrolase	Regulator
Q7626_RS05485 (Q7626_05480)	micB	1099112..1100461 (-)	1350	WP_000886213.1	cell wall metabolism sensor histidine kinase VicK	Regulator
Q7626_RS05490 (Q7626_05485)	micA	1100454..1101158 (-)	705	WP_000722076.1	response regulator YycF	Regulator
Q7626_RS05495 (Q7626_05490)	mutY	1101214..1102389 (-)	1176	WP_000886152.1	A/G-specific adenine glycosylase	-
Q7626_RS05500 (Q7626_05495)	-	1102486..1102611 (+)	126	WP_001818232.1	hypothetical protein	-
Q7626_RS05505 (Q7626_05500)	-	1102717..1104387 (-)	1671	WP_000845285.1	formate--tetrahydrofolate ligase	-
Q7626_RS05510 (Q7626_05505)	coaB	1104617..1105306 (+)	690	WP_000699495.1	phosphopantothenate--cysteine ligase	-
Q7626_RS05515 (Q7626_05510)	coaC	1105318..1105869 (+)	552	WP_001284128.1	phosphopantothenoylcysteine decarboxylase	-

Sequence

Protein

• Length: 234 a.a.
• Molecular weight: 26815.63 Da
• Isoelectric Point: 4.7164

>NTDB_id=863883 Q7626_RS05490 WP_000722076.1 1100454..1101158(-) (micA) [Streptococcus pneumoniae strain 2018C08-270]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide

• Length: 705 bp

>NTDB_id=863883 Q7626_RS05490 WP_000722076.1 1100454..1101158(-) (micA) [Streptococcus pneumoniae strain 2018C08-270]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGTCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (154-229)

3D structure

• PDB: 1NXS
• PDB: 2A9O
• PDB: 2A9P

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
micA	Streptococcus pneumoniae Cp1015	100	100	1
vicR	Streptococcus mutans UA159	78.541	99.573	0.782
covR	Streptococcus salivarius strain HSISS4	44.156	98.718	0.436
covR	Lactococcus lactis subsp. lactis strain DGCC12653	43.478	98.291	0.427
scnR	Streptococcus mutans UA159	38.197	99.573	0.38