Detailed information NTG0848433

Bioinformatically predicted

Overview

• Name: pilC
• Type: Machinery gene
• Locus tag: QTV62_RS08225
• Genome accession: NZ_CP128527
• Coordinates: 1587053..1588249 (+)
• Length: 398 a.a.
• NCBI ID: WP_006248403.1
• Uniprot ID: A0A249A0I8
• Organism: Mannheimia haemolytica strain 171096
• Function: type IV pilus biogenesis and function (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1582053..1593249

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
QTV62_RS08195	proB	1582449..1583533 (-)	1085	Protein_1580	glutamate 5-kinase	-
QTV62_RS08200	-	1583645..1584139 (+)	495	WP_289344776.1	dihydrofolate reductase	-
QTV62_RS08205	-	1584259..1584489 (+)	231	WP_006248398.1	YgjV family protein	-
QTV62_RS08210	radA	1584544..1585923 (-)	1380	WP_006248399.1	DNA repair protein RadA	-
QTV62_RS08215	pilA	1586104..1586583 (+)	480	WP_006248401.1	prepilin peptidase-dependent pilin	Machinery gene
QTV62_RS08220	-	1586604..1587047 (+)	444	Protein_1585	pilus assembly protein PilB	-
QTV62_RS08225	pilC	1587053..1588249 (+)	1197	WP_006248403.1	type II secretion system F family protein	Machinery gene
QTV62_RS08230	-	1588252..1588908 (+)	657	WP_006248404.1	prepilin peptidase	-
QTV62_RS08235	coaE	1588944..1589579 (+)	636	WP_006248405.1	dephospho-CoA kinase	-
QTV62_RS08240	yacG	1589561..1589746 (+)	186	WP_006248406.1	DNA gyrase inhibitor YacG	-
QTV62_RS08245	holA	1589747..1590772 (-)	1026	WP_006253426.1	DNA polymerase III subunit delta	-
QTV62_RS08250	lptE	1590815..1591303 (-)	489	WP_006248408.1	LPS assembly lipoprotein LptE	-

Sequence

Protein

• Length: 398 a.a.
• Molecular weight: 45186.75 Da
• Isoelectric Point: 9.4698

>NTDB_id=848433 QTV62_RS08225 WP_006248403.1 1587053..1588249(+) (pilC) [Mannheimia haemolytica strain 171096]
MTKIYEFHWQAQSRFGQKQRGKRLATNRDMLENLLLAQGYQHIRISRNFVLSANPKKEEVNSLLSQLALLVNSAMPLKQA
LSMLLQNCRNIRLYLWLNELIQHIESGYAFSQSLEKLGEFVTNQEIQLIKMGEQSGKLGIMLTNLAESRAKLEKLAKKVK
KILFYPVIVLLISLALSIGLLVLIVPQFAQLYGSKDKTLPLITDILFTLSECLIEQGTVLLGTLLLAVIFYLFFAKKSRL
VAKWKMALWAKMPLFSRIIEQSRIIFFSQNIALMLNAHIPLDVALRSFLSEKNDDPILQQEIGTMLNLLQQGYKFSQGIN
PNVFGAEMAQMLEVGEKSGNVAKMCEHISEMYQQKLDYQIDILSQLLEPMLMLIMGVIVGTIIVGLYLPIFDMGALVE

Nucleotide

• Length: 1197 bp

>NTDB_id=848433 QTV62_RS08225 WP_006248403.1 1587053..1588249(+) (pilC) [Mannheimia haemolytica strain 171096]
ATGACGAAAATCTATGAATTTCATTGGCAAGCCCAGAGCCGATTTGGGCAAAAACAGCGGGGCAAGCGGTTGGCAACGAA
TCGAGACATGTTGGAAAACCTTTTGCTGGCACAAGGTTATCAGCATATTCGGATTAGCCGAAATTTTGTGCTTTCAGCAA
ACCCGAAAAAAGAAGAGGTGAATAGCTTGCTATCACAGCTTGCATTGTTGGTTAATTCTGCCATGCCGTTAAAACAGGCA
TTATCTATGTTGTTGCAAAACTGCCGAAATATCCGCCTTTATCTATGGCTTAATGAGCTGATTCAGCATATTGAAAGTGG
CTATGCTTTTTCACAATCGTTGGAGAAATTGGGTGAATTTGTGACCAATCAGGAAATTCAGCTAATCAAAATGGGCGAAC
AAAGCGGAAAACTGGGCATTATGCTGACTAATTTAGCTGAAAGCCGAGCGAAATTGGAAAAATTGGCGAAAAAAGTGAAG
AAAATCCTGTTTTACCCGGTGATTGTGTTGCTGATTTCGCTCGCTTTATCTATCGGGCTATTGGTTTTGATTGTACCGCA
GTTTGCCCAACTTTATGGCTCAAAAGACAAAACTTTACCCCTCATTACCGATATTTTATTTACCCTTTCCGAATGCTTGA
TTGAGCAAGGCACAGTATTACTTGGCACGTTACTACTAGCGGTCATTTTTTACCTGTTTTTTGCAAAAAAGAGCAGGTTA
GTCGCAAAGTGGAAAATGGCTCTATGGGCTAAAATGCCACTGTTTAGCCGAATTATTGAGCAATCTCGCATTATCTTTTT
CAGCCAAAATATTGCCTTAATGCTGAATGCTCATATTCCGCTTGATGTTGCCTTGAGGTCGTTTTTATCCGAGAAAAATG
ATGACCCGATTTTACAGCAAGAAATTGGCACTATGCTTAATTTGTTACAACAAGGCTACAAATTTTCACAAGGGATCAAC
CCGAATGTGTTTGGTGCTGAGATGGCACAAATGCTTGAGGTTGGGGAGAAAAGTGGCAATGTGGCGAAAATGTGTGAGCA
TATTAGTGAGATGTACCAACAAAAATTAGATTACCAAATTGATATTTTGTCTCAGCTATTAGAACCGATGCTAATGTTGA
TAATGGGCGTGATTGTCGGCACTATTATTGTTGGGCTGTATTTACCGATTTTTGATATGGGGGCTTTGGTGGAGTAG

Domains

Predicted by InterproScan.

• Type II secretion system (T2SS), protein F (T2SSF) (64-186)

• Type II secretion system (T2SS), protein F (T2SSF) (267-389)

3D structure

• AlphaFold DB: A0A249A0I8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
pilC	Glaesserella parasuis strain SC1401	54	100	0.543
pilC	Haemophilus influenzae Rd KW20	42.145	100	0.425
pilC	Haemophilus influenzae 86-028NP	41.147	100	0.415