Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   QPL68_RS13220 Genome accession   NZ_CP126629
Coordinates   2717375..2718004 (+) Length   209 a.a.
NCBI ID   WP_000153530.1    Uniprot ID   D9IFM7
Organism   Staphylococcus aureus strain 35-42     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 2712375..2723004
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  QPL68_RS13195 (QPL68_13195) - 2712872..2713858 (-) 987 WP_000999712.1 aromatic acid exporter family protein -
  QPL68_RS13200 (QPL68_13200) map 2714268..2715026 (+) 759 WP_063651082.1 type I methionyl aminopeptidase -
  QPL68_RS13205 (QPL68_13205) - 2715243..2715629 (+) 387 WP_001110174.1 hypothetical protein -
  QPL68_RS13210 (QPL68_13210) liaF 2715644..2716345 (+) 702 WP_000149064.1 cell wall-active antibiotics response protein LiaF -
  QPL68_RS13215 (QPL68_13215) vraS 2716342..2717385 (+) 1044 WP_001017131.1 sensor histidine kinase Regulator
  QPL68_RS13220 (QPL68_13220) vraR 2717375..2718004 (+) 630 WP_000153530.1 two-component system response regulator VraR Regulator
  QPL68_RS13225 (QPL68_13225) - 2718117..2719334 (-) 1218 WP_063651080.1 YihY/virulence factor BrkB family protein -
  QPL68_RS13230 (QPL68_13230) - 2719612..2719887 (-) 276 WP_063651078.1 YtxH domain-containing protein -
  QPL68_RS13235 (QPL68_13235) - 2719894..2720358 (-) 465 WP_063651075.1 low molecular weight protein-tyrosine-phosphatase -
  QPL68_RS13240 (QPL68_13240) - 2720505..2720705 (+) 201 WP_000180460.1 DUF1128 family protein -
  QPL68_RS13245 (QPL68_13245) - 2720708..2721964 (+) 1257 WP_217151847.1 aminopeptidase -
  QPL68_RS13250 (QPL68_13250) - 2722054..2722584 (+) 531 WP_000184381.1 acyl-CoA thioesterase -

Sequence

Protein


Download         Length: 209 a.a.        Molecular weight: 23545.29 Da        Isoelectric Point: 5.3889

>NTDB_id=839306 QPL68_RS13220 WP_000153530.1 2717375..2718004(+) (vraR) [Staphylococcus aureus strain 35-42]
MTIKVLFVDDHEMVRIGISSYLSTQSDIEVVGEGASGKEAIAKAHELKPDLILMDLLMDDMDGVEATTQIKKDLPQIKVL
MLTSFIEDKEVYRALDAGVDSYILKTTSAKDIADAVRKTSRGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIA
KGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ

Nucleotide


Download         Length: 630 bp        

>NTDB_id=839306 QPL68_RS13220 WP_000153530.1 2717375..2718004(+) (vraR) [Staphylococcus aureus strain 35-42]
ATGACGATTAAAGTATTGTTTGTGGATGATCATGAAATGGTACGTATAGGAATTTCAAGTTATCTATCAACGCAAAGTGA
TATTGAAGTAGTTGGTGAAGGCGCTTCTGGTAAAGAAGCAATTGCCAAAGCCCATGAGTTGAAGCCAGATTTAATTTTAA
TGGATTTACTTATGGATGACATGGATGGTGTAGAAGCGACGACTCAGATTAAAAAAGATTTACCGCAAATTAAAGTATTA
ATGTTAACTAGTTTTATTGAAGATAAAGAGGTATATCGTGCATTAGATGCAGGTGTCGATAGTTACATTTTAAAAACAAC
AAGTGCAAAAGATATCGCCGATGCAGTTCGTAAAACTTCTAGAGGAGAATCTGTTTTTGAACCGGAAGTTTTAGTGAAAA
TGCGTAACCGTATGAAAAAGCGCGCAGAGTTATATGAAATGCTTACAGAACGAGAAATGGAAATATTATTATTGATTGCG
AAAGGTTACTCAAATCAAGAAATTGCTAGTGCATCGCATATTACTATTAAAACGGTTAAGACACATGTGAGTAACATTTT
AAGTAAGTTAGAAGTGCAAGATAGAACACAAGCTGTTATCTATGCATTCCAACATAATTTAATTCAATAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-116)

Bacterial regulatory proteins, luxR family (GerE)

(147-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB D9IFM7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

99.522

100

0.995
  degU Bacillus subtilis subsp. subtilis str. 168

34.821

100

0.373