Detailed information    

insolico Bioinformatically predicted

Overview

Name   comEC/celB   Type   Machinery gene
Locus tag   H7677_RS06075 Genome accession   NZ_AP023391
Coordinates   1234825..1237062 (-) Length   745 a.a.
NCBI ID   WP_024381561.1    Uniprot ID   A0A075SIT1
Organism   Streptococcus suis strain DAT299     
Function   ssDNA transport into the cell (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1229825..1242062
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H7677_RS06045 (DAT299_11570) tmk 1229931..1230569 (-) 639 WP_014735979.1 dTMP kinase -
  H7677_RS06050 (DAT299_11580) - 1230744..1231610 (+) 867 WP_024379692.1 YitT family protein -
  H7677_RS06055 (DAT299_11590) - 1231647..1232918 (-) 1272 WP_184493064.1 toxic anion resistance protein -
  H7677_RS06060 (DAT299_11600) - 1232924..1233751 (-) 828 WP_184493066.1 hypothetical protein -
  H7677_RS06065 (DAT299_11610) - 1233845..1234501 (-) 657 WP_023370708.1 CBS domain-containing protein -
  H7677_RS06070 (DAT299_11620) - 1234680..1234823 (-) 144 WP_002935351.1 transposase -
  H7677_RS06075 (DAT299_11630) comEC/celB 1234825..1237062 (-) 2238 WP_024381561.1 DNA internalization-related competence protein ComEC/Rec2 Machinery gene
  H7677_RS06080 (DAT299_11640) comEA/celA/cilE 1237046..1237708 (-) 663 WP_184493068.1 helix-hairpin-helix domain-containing protein Machinery gene
  H7677_RS06085 (DAT299_11650) - 1237771..1238520 (-) 750 WP_012775039.1 lysophospholipid acyltransferase family protein -
  H7677_RS06090 (DAT299_11660) - 1238667..1240112 (+) 1446 WP_184493070.1 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L- lysine ligase -
  H7677_RS06095 (DAT299_11670) - 1240264..1241049 (+) 786 WP_014636900.1 ABC transporter ATP-binding protein -
  H7677_RS06100 (DAT299_11680) - 1241062..1241991 (+) 930 WP_184493072.1 ABC transporter substrate-binding protein -

Sequence

Protein


Download         Length: 745 a.a.        Molecular weight: 84159.00 Da        Isoelectric Point: 7.1885

>NTDB_id=82902 H7677_RS06075 WP_024381561.1 1234825..1237062(-) (comEC/celB) [Streptococcus suis strain DAT299]
MSRLSKLPCQPVHLAVLAVAAYFAVHSFSLLTMCLLSLVLAVFGVRQGKTVFLKTLPLLTLCGLFFGCQKVQWERAAQSA
PEQVTTVQVIPDTIDINGDSLSFRGRADGQNYQVFYKLTSQEEQTYFQNLADLVQLEVEAEVSLPAGQRNFKGFDYQAYL
KTQGIYRTVKLTAIKKIVPVQSWNVFDWLSTWRRQALVYVKTNFPAPMSHYMTGLLFGELDSDFDQMSDLYSSLGIIHLF
ALSGMQVGFFIDKFRWILLRLGLTKETVDKLQIPFSLVYAGLTGFSVSVVRSLVQKILGNLGLRKLDNFAVTVFICLLIL
PRFLLTAGGVLTFTYAFLLTVFDFEDLGQVKKAAVESLSISLGILPVLMTYFYAFQPLSILLTFVFSFVFDVLLLPGLSV
IFLLSPVVKMTWVNGFFVFMEKIIVWVADLGLRPWILGKPSELVLLLLLVSLFLLYDFHRRKKWLLGLSLVLALLFFITK
HPLENEVTVLDIGQGDSIFLRDMRGRTVLIDVGGRVDFAAKEAWQERSRQANAERTLIPYLHSRGVDRIDSLVLTHTDTD
HVGDVLEVAKQVQIGRIYVSPGSLTVPDFVATLKEINVPVHVVEVGERLPIFDSYLEVLYPDGTGDGGNNDSIVLYGRLL
KTNFLFTGDLEQGELDLIESYPNLPVDVLKAGHHGSKGSSYPEFLDHIEAKIALVSAGENNRYKHPHQETLERFDSRNIQ
VYRTDQQGAIRFRGWREWRIETVRR

Nucleotide


Download         Length: 2238 bp        

>NTDB_id=82902 H7677_RS06075 WP_024381561.1 1234825..1237062(-) (comEC/celB) [Streptococcus suis strain DAT299]
ATGTCACGGTTGAGTAAGCTCCCCTGCCAGCCCGTTCACCTGGCAGTCTTGGCGGTGGCAGCTTACTTTGCAGTCCACTC
TTTTTCCCTCTTGACAATGTGCCTGCTCAGCTTGGTGTTAGCTGTCTTTGGTGTTCGGCAAGGTAAGACAGTTTTCCTCA
AAACGCTGCCGCTTCTAACCCTGTGTGGTCTCTTTTTCGGATGCCAAAAGGTCCAATGGGAGCGGGCAGCTCAGTCAGCC
CCAGAGCAAGTGACGACTGTGCAGGTCATTCCAGATACCATAGACATCAATGGCGACAGCTTGTCTTTTCGTGGTCGGGC
TGATGGACAAAACTATCAGGTTTTCTACAAATTAACCAGTCAGGAGGAGCAGACCTATTTTCAAAATCTGGCAGACCTGG
TCCAGCTAGAAGTGGAAGCAGAGGTCAGCCTGCCAGCTGGTCAGCGGAATTTCAAGGGCTTTGATTATCAGGCCTATCTG
AAAACACAGGGCATCTATCGGACTGTCAAGCTAACGGCGATTAAGAAGATTGTCCCTGTCCAGTCTTGGAATGTTTTTGA
CTGGCTGTCAACTTGGCGGAGGCAGGCCTTGGTCTATGTCAAAACCAATTTTCCGGCTCCCATGAGTCACTACATGACAG
GGCTTTTGTTTGGGGAGCTGGATAGTGATTTTGACCAGATGAGTGACCTCTATTCCAGTCTAGGAATCATTCATCTCTTT
GCCCTGTCTGGTATGCAGGTGGGCTTTTTCATCGACAAGTTTCGTTGGATTTTGTTGCGTCTGGGCTTGACCAAGGAAAC
AGTGGATAAGTTACAAATTCCCTTTTCCCTTGTCTATGCTGGTTTGACAGGCTTTTCTGTGTCGGTGGTGCGGTCCTTGG
TCCAAAAAATTCTGGGTAATCTAGGCTTGCGGAAGTTGGATAATTTTGCGGTGACGGTCTTTATCTGTCTGTTGATACTG
CCCCGATTTTTACTGACAGCAGGAGGAGTGCTGACTTTTACTTATGCTTTCTTGCTGACGGTCTTTGATTTTGAGGATTT
GGGGCAGGTCAAAAAGGCTGCGGTGGAGAGCCTCAGTATTTCACTGGGAATTTTGCCGGTGCTTATGACCTATTTCTATG
CCTTTCAGCCTCTATCTATCCTCTTGACCTTTGTCTTTTCCTTTGTCTTTGATGTCCTACTCTTGCCAGGTTTGTCAGTC
ATTTTTCTCCTGTCGCCAGTTGTCAAGATGACTTGGGTCAACGGATTTTTCGTCTTTATGGAGAAAATCATTGTCTGGGT
GGCTGATTTGGGATTGCGGCCTTGGATACTGGGCAAGCCGTCTGAGCTGGTCCTCTTGCTTTTGCTGGTCAGCCTCTTCT
TGCTCTACGATTTCCACAGGAGAAAGAAATGGCTTCTAGGACTGAGCTTGGTCCTCGCTCTGCTATTTTTCATCACCAAA
CACCCGCTGGAAAATGAGGTGACGGTGCTGGACATCGGGCAGGGGGACAGCATCTTTTTGCGGGATATGCGGGGGCGGAC
GGTTCTGATTGATGTAGGCGGACGAGTCGATTTCGCGGCCAAGGAAGCGTGGCAGGAGCGGTCTCGGCAGGCAAATGCAG
AGCGGACTTTGATTCCCTATCTGCATAGTCGGGGTGTGGATAGGATTGATAGTTTAGTCCTGACCCACACCGACACAGAC
CATGTGGGGGATGTGCTGGAAGTGGCGAAGCAGGTCCAGATTGGTCGGATTTACGTGTCGCCGGGAAGCCTGACGGTGCC
TGACTTTGTAGCCACCTTGAAAGAAATTAATGTCCCTGTTCATGTTGTTGAGGTGGGCGAACGCTTACCAATTTTTGACT
CTTACCTGGAAGTCCTTTATCCAGATGGGACAGGAGACGGTGGCAATAATGACTCCATTGTCCTTTACGGTCGCTTGCTG
AAAACTAATTTTCTCTTTACAGGGGACTTGGAGCAGGGGGAGTTGGACTTGATAGAATCTTATCCTAACCTGCCTGTCGA
TGTCCTCAAAGCCGGTCACCACGGCTCCAAAGGTTCTTCCTATCCTGAATTTTTGGACCATATCGAAGCCAAGATTGCCT
TGGTATCTGCTGGAGAAAACAACCGCTACAAGCATCCTCACCAAGAAACCTTGGAACGATTTGATAGTCGCAATATCCAA
GTCTATCGTACAGACCAGCAAGGAGCCATTCGCTTCCGAGGTTGGAGGGAGTGGAGGATTGAAACGGTGAGGAGGTAA

Domains

Predicted by InterproScan.

Metallo-beta-lactamase superfamily (Lactamase_B)

(493-698)

Domain of unknown function (DUF4131) (DUF4131)

(30-175)

Competence protein (Competence)

(215-461)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A075SIT1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comEC/celB Streptococcus mitis SK321

53.774

99.597

0.536
  comEC/celB Streptococcus mitis NCTC 12261

52.782

98.926

0.522
  comEC/celB Streptococcus pneumoniae TIGR4

51.973

98.658

0.513
  comEC/celB Streptococcus pneumoniae Rx1

51.701

98.658

0.51
  comEC/celB Streptococcus pneumoniae D39

51.701

98.658

0.51
  comEC/celB Streptococcus pneumoniae R6

51.701

98.658

0.51
  comEC Lactococcus lactis subsp. cremoris KW2

48.999

100

0.493

Multiple sequence alignment