Detailed information    

insolico Bioinformatically predicted

Overview

Name   vicR   Type   Regulator
Locus tag   KUN2590_RS07745 Genome accession   NZ_AP023387
Coordinates   1488622..1489332 (-) Length   236 a.a.
NCBI ID   WP_002985645.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NIH34     
Function   repress comCDE expression; repress comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1483622..1494332
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  KUN2590_RS07730 (SPNIH34_14840) rnc 1485329..1486021 (-) 693 WP_002990670.1 ribonuclease III -
  KUN2590_RS07735 (SPNIH34_14850) vicX 1486464..1487273 (-) 810 WP_002985641.1 MBL fold metallo-hydrolase Regulator
  KUN2590_RS07740 (SPNIH34_14860) vicK 1487277..1488629 (-) 1353 WP_002995609.1 cell wall metabolism sensor histidine kinase VicK Regulator
  KUN2590_RS07745 (SPNIH34_14870) vicR 1488622..1489332 (-) 711 WP_002985645.1 response regulator YycF Regulator
  KUN2590_RS07750 (SPNIH34_14880) - 1489494..1490489 (-) 996 WP_011054269.1 DUF3114 domain-containing protein -
  KUN2590_RS07755 (SPNIH34_14890) - 1490585..1491832 (-) 1248 WP_011054268.1 AMP-binding protein -
  KUN2590_RS07760 (SPNIH34_14900) - 1491789..1492937 (-) 1149 WP_011054267.1 acetyl-CoA C-acyltransferase -
  KUN2590_RS07765 (SPNIH34_14910) - 1493332..1493481 (-) 150 WP_002994198.1 hypothetical protein -

Sequence

Protein


Download         Length: 236 a.a.        Molecular weight: 27083.99 Da        Isoelectric Point: 4.9038

>NTDB_id=82693 KUN2590_RS07745 WP_002985645.1 1488622..1489332(-) (vicR) [Streptococcus pyogenes strain NIH34]
MKKILIVDDEKPISDIIKFNLTKEGYDIVTAFDGREAVTIFEEEKPDLIILDLMLPELDGLEVAKEIRKTSHVPIIMLSA
KDSEFDKVIGLEIGADDYVTKPFSNRELLARVKAHLRRTETIETAVAEENASSGTQELTIGNLQILPDAFVAKKHGQEVE
LTHREFELLHHLANHMGQVMTREHLLEIVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMKSYD

Nucleotide


Download         Length: 711 bp        

>NTDB_id=82693 KUN2590_RS07745 WP_002985645.1 1488622..1489332(-) (vicR) [Streptococcus pyogenes strain NIH34]
ATGAAAAAAATACTTATTGTGGATGATGAAAAACCGATTTCTGACATTATTAAGTTTAATTTGACAAAAGAAGGTTATGA
CATTGTTACAGCTTTTGATGGACGCGAAGCGGTAACAATTTTTGAAGAAGAAAAGCCAGATTTAATTATTCTTGATTTGA
TGCTCCCTGAGTTGGACGGTCTTGAAGTAGCCAAGGAAATTCGTAAAACCAGTCATGTCCCGATTATTATGTTGTCGGCT
AAAGATAGTGAGTTTGACAAGGTTATTGGACTTGAAATTGGGGCTGATGATTACGTGACCAAGCCTTTTTCTAATCGGGA
ATTGCTGGCGCGTGTCAAGGCTCATCTGCGTCGTACCGAAACTATTGAAACGGCTGTTGCAGAAGAAAATGCTTCTTCAG
GTACACAGGAACTAACCATTGGTAATTTACAGATTTTACCAGATGCGTTTGTTGCTAAAAAACATGGTCAAGAGGTAGAG
TTGACCCATCGTGAATTTGAACTATTGCATCATCTAGCTAACCATATGGGTCAGGTGATGACACGAGAACACTTATTGGA
AATTGTTTGGGGATATGATTATTTTGGCGATGTGCGCACGGTTGATGTGACTGTTCGTCGTCTTCGTGAAAAAATTGAAG
ACACACCAAGTCGTCCTGAGTATATTTTAACAAGACGTGGTGTTGGGTACTACATGAAATCTTATGACTAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-113)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(156-231)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vicR Streptococcus mutans UA159

90.254

100

0.903
  micA Streptococcus pneumoniae Cp1015

79.06

99.153

0.784
  covR Streptococcus salivarius strain HSISS4

44.828

98.305

0.441
  covR Lactococcus lactis subsp. lactis strain DGCC12653

44.397

98.305

0.436
  scnR Streptococcus mutans UA159

36.91

98.729

0.364

Multiple sequence alignment