Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   QAO20_RS12375 Genome accession   NZ_CP123106
Coordinates   2492452..2493081 (+) Length   209 a.a.
NCBI ID   WP_000153535.1    Uniprot ID   W8TS97
Organism   Staphylococcus aureus strain IT-MSSA50     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 2487452..2498081
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  QAO20_RS12350 (QAO20_12315) - 2487776..2488762 (-) 987 WP_000999713.1 FUSC family protein -
  QAO20_RS12355 (QAO20_12320) map 2489345..2490103 (+) 759 WP_000636142.1 type I methionyl aminopeptidase -
  QAO20_RS12360 (QAO20_12325) - 2490320..2490706 (+) 387 WP_001110176.1 hypothetical protein -
  QAO20_RS12365 (QAO20_12330) liaF 2490721..2491422 (+) 702 WP_000149064.1 cell wall-active antibiotics response protein LiaF -
  QAO20_RS12370 (QAO20_12335) vraS 2491419..2492462 (+) 1044 WP_001017131.1 sensor histidine kinase Regulator
  QAO20_RS12375 (QAO20_12340) vraR 2492452..2493081 (+) 630 WP_000153535.1 two-component system response regulator VraR Regulator
  QAO20_RS12380 (QAO20_12345) - 2493194..2494411 (-) 1218 WP_000037092.1 YihY/virulence factor BrkB family protein -
  QAO20_RS12385 (QAO20_12350) - 2494689..2494964 (-) 276 WP_000428172.1 YtxH domain-containing protein -
  QAO20_RS12390 (QAO20_12355) - 2494971..2495435 (-) 465 WP_000228666.1 low molecular weight protein-tyrosine-phosphatase -
  QAO20_RS12395 (QAO20_12360) - 2495582..2495782 (+) 201 WP_000180460.1 DUF1128 family protein -
  QAO20_RS12400 (QAO20_12365) - 2495785..2497041 (+) 1257 WP_001798674.1 aminopeptidase -
  QAO20_RS12405 (QAO20_12370) - 2497131..2497661 (+) 531 WP_000184381.1 acyl-CoA thioesterase -

Sequence

Protein


Download         Length: 209 a.a.        Molecular weight: 23559.32 Da        Isoelectric Point: 5.3935

>NTDB_id=818828 QAO20_RS12375 WP_000153535.1 2492452..2493081(+) (vraR) [Staphylococcus aureus strain IT-MSSA50]
MTIKVLFVDDHEMVRIGISSYLSTQSDIEVVGEGASGKEAIAKAHELKPDLILMDLLMEDMDGVEATTQIKKDLPQIKVL
MLTSFIEDKEVYRALDAGVDSYILKTTSAKDIADAVRKTSRGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIA
KGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ

Nucleotide


Download         Length: 630 bp        

>NTDB_id=818828 QAO20_RS12375 WP_000153535.1 2492452..2493081(+) (vraR) [Staphylococcus aureus strain IT-MSSA50]
ATGACGATTAAAGTATTGTTTGTGGATGATCATGAAATGGTACGTATAGGAATTTCAAGTTATCTATCAACGCAAAGTGA
TATTGAAGTAGTTGGTGAAGGCGCTTCTGGTAAAGAAGCAATTGCCAAAGCCCATGAGTTGAAGCCAGATTTAATTTTAA
TGGATTTACTTATGGAAGACATGGATGGTGTAGAAGCGACGACTCAGATTAAAAAAGATTTACCGCAAATTAAAGTATTA
ATGTTAACTAGTTTTATTGAAGATAAAGAGGTATATCGTGCATTAGATGCAGGTGTCGATAGTTACATTTTAAAAACAAC
AAGTGCAAAAGATATCGCCGATGCAGTTCGTAAAACTTCTAGAGGAGAATCTGTTTTTGAACCGGAAGTTTTAGTGAAAA
TGCGTAACCGTATGAAAAAGCGTGCAGAGTTATATGAAATGCTTACAGAACGAGAAATGGAAATATTATTATTGATTGCG
AAAGGTTACTCAAATCAAGAAATTGCTAGTGCATCGCATATTACTATTAAAACGGTTAAGACACATGTGAGTAACATTTT
AAGTAAGTTAGAAGTGCAAGATAGAACACAAGCTGTTATCTATGCATTCCAACATAATTTAATTCAATAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-116)

Bacterial regulatory proteins, luxR family (GerE)

(147-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB W8TS97

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

100

100

1
  degU Bacillus subtilis subsp. subtilis str. 168

34.821

100

0.373