Detailed information NTG0818827

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: QAO20_RS12370
• Genome accession: NZ_CP123106
• Coordinates: 2491419..2492462 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain IT-MSSA50
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2486419..2497462

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
QAO20_RS12340 (QAO20_12305)	-	2486851..2486961 (+)	111	WP_001790257.1	hypothetical protein	-
QAO20_RS12345 (QAO20_12310)	-	2486990..2487403 (+)	414	WP_025173966.1	hypothetical protein	-
QAO20_RS12350 (QAO20_12315)	-	2487776..2488762 (-)	987	WP_000999713.1	FUSC family protein	-
QAO20_RS12355 (QAO20_12320)	map	2489345..2490103 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
QAO20_RS12360 (QAO20_12325)	-	2490320..2490706 (+)	387	WP_001110176.1	hypothetical protein	-
QAO20_RS12365 (QAO20_12330)	liaF	2490721..2491422 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
QAO20_RS12370 (QAO20_12335)	vraS	2491419..2492462 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
QAO20_RS12375 (QAO20_12340)	vraR	2492452..2493081 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
QAO20_RS12380 (QAO20_12345)	-	2493194..2494411 (-)	1218	WP_000037092.1	YihY/virulence factor BrkB family protein	-
QAO20_RS12385 (QAO20_12350)	-	2494689..2494964 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
QAO20_RS12390 (QAO20_12355)	-	2494971..2495435 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
QAO20_RS12395 (QAO20_12360)	-	2495582..2495782 (+)	201	WP_000180460.1	DUF1128 family protein	-
QAO20_RS12400 (QAO20_12365)	-	2495785..2497041 (+)	1257	WP_001798674.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=818827 QAO20_RS12370 WP_001017131.1 2491419..2492462(+) (vraS) [Staphylococcus aureus strain IT-MSSA50]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=818827 QAO20_RS12370 WP_001017131.1 2491419..2492462(+) (vraS) [Staphylococcus aureus strain IT-MSSA50]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1