Detailed information NTG0811320

Bioinformatically predicted

Overview

• Name: ciaH
• Type: Regulator
• Locus tag: P8191_RS02250
• Genome accession: NZ_CP121250
• Coordinates: 420012..421322 (+)
• Length: 436 a.a.
• NCBI ID: WP_010922354.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain 1044
• Function: Required for optimal comC expression (predicted from homology) Competence regulation

Genomic Context

Location: 415012..426322

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
P8191_RS02235 (P8191_02235)	phoU	415604..416257 (+)	654	WP_002984514.1	phosphate signaling complex protein PhoU	-
P8191_RS02240 (P8191_02240)	-	416462..418999 (+)	2538	WP_010922356.1	M1 family metallopeptidase	-
P8191_RS02245 (P8191_02245)	ciaR	419345..420019 (+)	675	WP_010922355.1	response regulator transcription factor	Regulator
P8191_RS02250 (P8191_02250)	ciaH	420012..421322 (+)	1311	WP_010922354.1	HAMP domain-containing sensor histidine kinase	Regulator
P8191_RS02255 (P8191_02255)	rpsT	421447..421695 (-)	249	WP_009881183.1	30S ribosomal protein S20	-
P8191_RS02260 (P8191_02260)	coaA	421749..422669 (-)	921	WP_010922353.1	type I pantothenate kinase	-
P8191_RS02265 (P8191_02265)	-	422937..423530 (+)	594	WP_010922352.1	class I SAM-dependent methyltransferase	-
P8191_RS02270 (P8191_02270)	-	424183..424572 (+)	390	WP_011285547.1	cytidine deaminase	-
P8191_RS02275 (P8191_02275)	-	424666..425718 (+)	1053	WP_002989701.1	BMP family protein	-

Sequence

Protein

• Length: 436 a.a.
• Molecular weight: 50013.52 Da
• Isoelectric Point: 9.0831

>NTDB_id=811320 P8191_RS02250 WP_010922354.1 420012..421322(+) (ciaH) [Streptococcus pyogenes strain 1044]
MNKLKKEILSDNYNHFFHFFAVFTGIFVIMTIIILQIMRFGVYSSVDSSLVSVSNNASSYANRTMARISSFYFDTENNII
KALPDSDSSKLLGTPAANTDIILFSANGTILNAFDAFSNYQNFHLDKRRLGSIETTSLMNFYGQEEKYHTITVGVHIKNY
PAVAYMMAVVNVEQLDRANERYERIIIIVMSVFWLISILASIYLAKWSRKPILESYEKQKMFVENASHELRTPLAVLQNR
LESLFRKPNETILENSEHLASSLDEVRNMRILTTNLLNLARRDDGINPQWTHLDTDFFNAIFENYELVAKEYGKIFYFQN
QVNRSLRMDKALLKQLITILFDNAIKYTDKNGIIEIIVKTTDKNLLISVIDNGPGITDEEKKKIFDRFYRVDKARTRQTG
GFGLGLALAQQIVMSLKGNITVKDNDPKGSIFEVKL

Nucleotide

• Length: 1311 bp

>NTDB_id=811320 P8191_RS02250 WP_010922354.1 420012..421322(+) (ciaH) [Streptococcus pyogenes strain 1044]
ATGAATAAATTAAAAAAAGAGATTTTATCAGATAACTATAACCACTTTTTTCATTTTTTTGCGGTTTTTACAGGTATTTT
TGTCATTATGACTATTATTATCTTACAGATTATGCGGTTTGGCGTTTATTCGTCAGTTGACAGTAGTTTAGTTTCTGTTA
GTAATAATGCAAGTAGCTATGCTAATCGTACGATGGCTAGAATATCTTCTTTTTACTTTGATACTGAAAATAACATTATT
AAGGCGCTGCCTGATTCAGATAGTTCTAAGTTATTAGGAACGCCTGCAGCTAATACAGATATCATTTTGTTTAGTGCTAA
TGGAACAATTTTAAATGCTTTTGATGCGTTTTCTAACTATCAAAATTTTCATTTAGATAAACGCCGGTTGGGGAGTATTG
AAACCACCAGTTTAATGAATTTTTATGGACAAGAAGAAAAATACCATACGATAACTGTAGGGGTTCATATCAAAAATTAT
CCTGCAGTTGCCTATATGATGGCAGTAGTAAATGTGGAACAATTAGACCGCGCTAATGAACGTTATGAGCGCATTATTAT
TATAGTTATGAGTGTTTTTTGGCTAATTTCTATTTTAGCAAGTATTTATTTAGCCAAGTGGAGCAGAAAACCTATTTTAG
AAAGCTATGAAAAACAAAAAATGTTTGTTGAAAATGCTAGTCATGAATTAAGGACCCCTTTGGCGGTCTTACAGAATCGT
CTGGAATCGCTTTTTCGTAAGCCCAACGAAACGATATTAGAAAATAGTGAGCATCTCGCTTCTAGTTTAGACGAGGTTCG
CAACATGCGCATCTTAACAACTAATTTATTAAATTTAGCAAGACGAGATGATGGCATTAATCCACAGTGGACTCATTTAG
ATACAGATTTTTTTAATGCTATTTTTGAGAATTATGAACTAGTTGCTAAAGAATATGGAAAAATATTTTATTTTCAGAAC
CAAGTCAATAGATCGTTAAGAATGGATAAGGCTTTACTAAAACAATTAATAACGATTTTATTTGACAATGCTATTAAATA
TACAGATAAAAATGGTATTATTGAAATTATAGTGAAAACAACGGACAAAAATTTATTAATTTCTGTTATTGATAATGGTC
CAGGGATAACAGATGAAGAAAAGAAAAAGATTTTTGATCGTTTTTATCGAGTTGACAAAGCTAGAACACGGCAAACAGGT
GGATTTGGCTTGGGGTTGGCTTTAGCTCAGCAAATCGTGATGTCTTTAAAAGGAAATATTACAGTAAAGGATAATGATCC
TAAAGGTAGTATTTTTGAAGTCAAACTATAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (329-436)

• His Kinase A (phospho-acceptor) domain (HisKA) (220-285)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaH	Streptococcus mutans UA159	57.895	100	0.58
ciaH	Streptococcus pneumoniae Rx1	51.37	100	0.516
ciaH	Streptococcus pneumoniae D39	51.37	100	0.516
ciaH	Streptococcus pneumoniae R6	51.37	100	0.516
ciaH	Streptococcus pneumoniae TIGR4	51.37	100	0.516