Detailed information NTG0810625

Bioinformatically predicted

Overview

• Name: vicK
• Type: Regulator
• Locus tag: P8R98_RS08595
• Genome accession: NZ_CP121159
• Coordinates: 1743378..1744727 (-)
• Length: 449 a.a.
• NCBI ID: WP_001065469.1
• Uniprot ID: R4ZB13
• Organism: Streptococcus agalactiae strain S1
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1738378..1749727

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
P8R98_RS08580	rnc	1741332..1742018 (-)	687	WP_000661525.1	ribonuclease III	-
P8R98_RS08585	-	1742194..1742562 (-)	369	WP_000719385.1	YbaN family protein	-
P8R98_RS08590	vicX	1742565..1743374 (-)	810	WP_001289498.1	MBL fold metallo-hydrolase	Regulator
P8R98_RS08595	vicK	1743378..1744727 (-)	1350	WP_001065469.1	cell wall metabolism sensor histidine kinase VicK	Regulator
P8R98_RS08600	vicR	1744720..1745430 (-)	711	WP_000722052.1	response regulator YycF	Regulator
P8R98_RS08605	-	1745770..1746525 (+)	756	WP_161501822.1	amino acid ABC transporter ATP-binding protein	-
P8R98_RS08610	-	1746537..1747337 (+)	801	WP_000946171.1	transporter substrate-binding domain-containing protein	-
P8R98_RS08615	-	1747350..1748045 (+)	696	WP_000173639.1	amino acid ABC transporter permease	-
P8R98_RS08620	-	1748057..1748707 (+)	651	WP_000100034.1	amino acid ABC transporter permease	-

Sequence

Protein

• Length: 449 a.a.
• Molecular weight: 51059.13 Da
• Isoelectric Point: 4.8621

>NTDB_id=810625 P8R98_RS08595 WP_001065469.1 1743378..1744727(-) (vicK) [Streptococcus agalactiae strain S1]
MNNSAANIRSFELALLFLLVFVAVYFVYLAVRDFKMSKNIRLLNWKVRDLIAGNYSDSILIQGDADLVELGESLNDLSDV
FRMAHDNLEQEKNRLASILTYMTDGVLATDRSGKIVMINETAQQQFNLAYDEALSMNIVDMLGSGSPYSFQDLVSKTPEV
VLNRRDENGEFVTLRIRFALNRRESGFISGLVAVSHDATEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALNE
EVAPSFIKVSLDETNRMMRMISDLLSLSRIDNEVTHLDVEMTNFTAFMTSILNRFDQIRNQKTVTGKVYEIVRDYPLKSI
WVEIDTDKMTQVIDNILNNAVKYSPDGGKITVNLRTTKTQMILSISDQGLGIPKKDLPLIFDRFYRVDKARSRQQGGTGL
GLSIAKEIVKQHKGFIWAKSEYGKGSTFTIVLPYDKDAVTYEEWEDVED

Nucleotide

• Length: 1350 bp

>NTDB_id=810625 P8R98_RS08595 WP_001065469.1 1743378..1744727(-) (vicK) [Streptococcus agalactiae strain S1]
ATGAATAATAGTGCTGCAAATATTAGGTCGTTTGAGCTAGCCTTACTTTTTTTACTAGTTTTTGTTGCTGTTTATTTTGT
TTATCTAGCGGTTAGAGATTTTAAAATGTCTAAAAATATCCGACTTTTGAATTGGAAAGTCAGAGATTTGATAGCAGGAA
ATTATTCAGATAGTATTCTAATTCAAGGTGATGCAGATTTGGTAGAATTAGGTGAAAGTCTAAATGATTTATCTGATGTC
TTCCGAATGGCACATGATAACTTAGAACAAGAAAAGAATCGCTTAGCAAGTATCTTAACTTATATGACTGACGGTGTGCT
GGCTACAGATCGTTCAGGAAAAATCGTTATGATTAATGAGACAGCCCAACAGCAGTTCAATCTAGCATATGATGAAGCTT
TATCAATGAATATTGTTGATATGTTAGGGTCAGGAAGTCCATATTCGTTCCAAGATTTAGTCTCTAAGACGCCAGAGGTA
GTTCTTAATAGACGTGATGAAAATGGTGAATTTGTTACCTTACGGATTCGATTTGCTTTGAACCGTCGTGAAAGTGGTTT
TATTTCCGGTTTAGTTGCAGTATCACACGATGCTACTGAGCAAGAGAAAGAAGAGCGTGAAAGAAGACTTTTTGTATCTA
ATGTTTCTCATGAACTTCGTACACCTTTGACATCTGTAAAATCTTATTTAGAAGCTTTAGATGAGGGAGCGCTCAATGAA
GAAGTTGCTCCAAGCTTCATTAAGGTATCTCTAGATGAAACAAATCGTATGATGCGTATGATATCAGATTTATTAAGTTT
ATCGCGCATTGATAATGAAGTAACGCATTTAGATGTTGAAATGACGAATTTTACAGCTTTCATGACCTCAATTTTGAATC
GATTTGACCAGATTAGAAATCAAAAAACAGTCACAGGAAAAGTTTATGAAATTGTCAGAGATTATCCTCTTAAGTCAATT
TGGGTGGAAATTGATACAGATAAGATGACTCAAGTGATTGATAACATTTTAAATAATGCAGTCAAGTATTCACCAGATGG
TGGTAAGATTACAGTTAATCTACGCACAACTAAAACGCAGATGATTTTATCAATATCAGACCAAGGCTTAGGTATTCCCA
AAAAAGATTTACCTCTCATCTTTGATCGTTTTTATCGTGTTGATAAGGCGAGAAGTCGTCAACAGGGTGGGACTGGACTT
GGTTTGTCAATTGCAAAAGAAATTGTTAAGCAGCATAAGGGATTTATTTGGGCTAAGAGTGAGTATGGTAAAGGGTCTAC
TTTTACAATCGTCTTGCCTTATGATAAAGATGCTGTAACTTATGAAGAATGGGAGGACGTTGAAGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (325-435)

• PAS fold (PAS) (94-180)

• His Kinase A (phospho-acceptor) domain (HisKA) (208-272)

3D structure

• AlphaFold DB: R4ZB13

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicK	Streptococcus mutans UA159	74.576	91.982	0.686
micB	Streptococcus pneumoniae Cp1015	67.436	96.437	0.65