Detailed information    

insolico Bioinformatically predicted

Overview

Name   crp   Type   Regulator
Locus tag   HIY_RS00175 Genome accession   NZ_AP022867
Coordinates   39555..40229 (-) Length   224 a.a.
NCBI ID   WP_005647998.1    Uniprot ID   Q4QLV0
Organism   Haemophilus influenzae strain 2018-Y40     
Function   promote expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 34555..45229
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HIY_RS00155 (HIY_00310) hinT 36263..36613 (+) 351 WP_005655947.1 purine nucleoside phosphoramidase -
  HIY_RS00160 (HIY_00320) - 36613..36963 (+) 351 WP_005655946.1 YcfL family protein -
  HIY_RS00165 (HIY_00330) nagZ 36967..38022 (+) 1056 WP_032821874.1 beta-N-acetylhexosaminidase -
  HIY_RS00170 (HIY_00340) rlmC 38015..39190 (+) 1176 WP_005655944.1 23S rRNA (uracil(747)-C(5))-methyltransferase RlmC -
  HIY_RS00175 (HIY_00350) crp 39555..40229 (-) 675 WP_005647998.1 cAMP-activated global transcriptional regulator CRP Regulator
  HIY_RS00180 (HIY_00360) - 40214..40465 (-) 252 WP_005647999.1 YheU family protein -
  HIY_RS00185 (HIY_00370) slmA 40487..41143 (-) 657 WP_005648000.1 nucleoid occlusion factor SlmA -
  HIY_RS00190 (HIY_00380) dut 41150..41602 (-) 453 WP_005655943.1 dUTP diphosphatase -
  HIY_RS00195 (HIY_00390) coaBC 41650..42852 (-) 1203 WP_005655942.1 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC -
  HIY_RS00200 (HIY_00400) radC 43016..43681 (+) 666 WP_013527272.1 DNA repair protein RadC -
  HIY_RS00205 (HIY_00410) rpmB 43895..44131 (+) 237 WP_005542826.1 50S ribosomal protein L28 -
  HIY_RS00210 (HIY_00420) rpmG 44143..44313 (+) 171 WP_005613503.1 50S ribosomal protein L33 -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25151.85 Da        Isoelectric Point: 6.8375

>NTDB_id=79544 HIY_RS00175 WP_005647998.1 39555..40229(-) (crp) [Haemophilus influenzae strain 2018-Y40]
MSNELTEIDEVVTSSQEEATQRDPVLDWFLTHCHLHKYPAKSTLIHAGEDATTLYYVIKGSVMVSSKDDEGKEMILTYLG
AGQFFGEAGLFDEGSKRSAWVKTKTTCEIAEISYKKYRQLIQANPEILMFLTAQLARRLQNTSRQVTNLAFLDVAGRIAQ
TLMNLAKQPEAMTHPDGMQIKITRQEIGQMVGCSRETVGRIIKMLEDQNLIHAHGKTIVVYGAR

Nucleotide


Download         Length: 675 bp        

>NTDB_id=79544 HIY_RS00175 WP_005647998.1 39555..40229(-) (crp) [Haemophilus influenzae strain 2018-Y40]
ATGTCAAATGAATTAACCGAAATTGATGAAGTTGTAACCTCCTCTCAAGAAGAGGCAACTCAACGAGATCCCGTTTTAGA
TTGGTTTCTTACTCACTGCCATTTGCATAAATATCCTGCAAAATCAACTTTAATTCATGCTGGGGAAGATGCCACCACGC
TGTATTATGTAATTAAAGGTTCTGTAATGGTATCTTCAAAAGATGATGAAGGCAAAGAGATGATCCTCACTTACTTAGGA
GCAGGACAATTTTTTGGCGAAGCGGGATTATTTGATGAAGGTTCAAAACGATCAGCTTGGGTAAAAACAAAAACAACATG
TGAAATTGCTGAAATTTCCTATAAGAAATATCGCCAGTTGATTCAGGCAAACCCTGAAATCTTAATGTTTCTCACTGCAC
AATTGGCAAGACGTTTGCAAAATACATCACGTCAAGTCACGAATTTGGCATTTTTAGACGTCGCAGGTCGCATCGCTCAA
ACTTTAATGAACTTAGCTAAACAGCCTGAAGCAATGACGCATCCTGATGGTATGCAAATCAAAATTACACGCCAAGAAAT
AGGGCAAATGGTGGGTTGTTCACGAGAAACTGTGGGGCGCATTATTAAGATGTTGGAGGATCAGAATCTTATCCACGCTC
ATGGAAAAACAATCGTTGTATATGGCGCAAGATAA

Domains

Predicted by InterproScan.

Cyclic nucleotide-binding domain (cNMP_binding)

(36-124)

Crp-like helix-turn-helix domain (HTH_Crp_2)

(156-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q4QLV0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  crp Haemophilus influenzae Rd KW20

100

100

1
  crp Vibrio cholerae strain A1552

75.49

91.071

0.687
  crp Acinetobacter baumannii D1279779

48.705

86.161

0.42

Multiple sequence alignment