Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   PUW52_RS04720 Genome accession   NZ_CP118078
Coordinates   934613..935959 (+) Length   448 a.a.
NCBI ID   WP_003024354.1    Uniprot ID   -
Organism   Streptococcus anginosus strain VSI16     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 929613..940959
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  PUW52_RS04690 (PUW52_04690) - 929758..931065 (+) 1308 WP_070654275.1 ISLre2 family transposase -
  PUW52_RS04695 (PUW52_04695) rplS 931538..931885 (+) 348 WP_003024326.1 50S ribosomal protein L19 -
  PUW52_RS04705 (PUW52_04705) - 932126..932869 (+) 744 WP_070241645.1 alpha/beta hydrolase -
  PUW52_RS04710 (PUW52_04710) - 933216..933674 (+) 459 WP_070812093.1 hypothetical protein -
  PUW52_RS04715 (PUW52_04715) ciaR 933949..934623 (+) 675 WP_003024352.1 response regulator transcription factor Regulator
  PUW52_RS04720 (PUW52_04720) ciaH 934613..935959 (+) 1347 WP_003024354.1 HAMP domain-containing sensor histidine kinase Regulator
  PUW52_RS04725 (PUW52_04725) - 936434..937882 (-) 1449 WP_070241644.1 alpha-amylase -
  PUW52_RS04730 (PUW52_04730) - 938059..939675 (+) 1617 WP_024052209.1 M20/M25/M40 family metallo-hydrolase -
  PUW52_RS04735 (PUW52_04735) - 939724..940233 (-) 510 WP_042754050.1 DNA topology modulation protein -
  PUW52_RS04740 (PUW52_04740) rpsT 940297..940548 (-) 252 WP_020999623.1 30S ribosomal protein S20 -

Sequence

Protein


Download         Length: 448 a.a.        Molecular weight: 51038.78 Da        Isoelectric Point: 10.1380

>NTDB_id=789849 PUW52_RS04720 WP_003024354.1 934613..935959(+) (ciaH) [Streptococcus anginosus strain VSI16]
MLNKLKKTWYADDFSYFIRNFGIFTLIFSAMTLIIIQVMRSSLYTTVDNNLKSLSQDSASVINLALARRVGMEQKSDNGE
PKTDTGDKELTDKPNVSANTEVILFDKNYKPIITSNNFLGLNKLSFNSKQLDRIRQVQVKSNYGRQETYRMILFEVKIPN
LETNVKYAAVFINISQLEQTSQNHEQLIVVVMISFWGISLIASVYLARVSVKPLLESIQKQKSFVENASHELRTPLAVLQ
NRLETLFRKPEATIMESSESIASSLDEVRNMKMLTTNLLNLARRDDGIKPEIGDVEPNFFNTTFTNYEMVAAENGKTFRF
DNRIHRMIKTDKTLLKQLMTILFDNALKYTDEDGVIELTISANDRNLFLKVSDNGPGISTADKKKIFDRFYRVDKARTRQ
TGGFGLGLSLAKQITEALKGTITVKDNKPKGTIFEVKIAIRTDNRKKK

Nucleotide


Download         Length: 1347 bp        

>NTDB_id=789849 PUW52_RS04720 WP_003024354.1 934613..935959(+) (ciaH) [Streptococcus anginosus strain VSI16]
ATGCTGAATAAACTTAAAAAAACATGGTATGCGGATGATTTTTCTTATTTCATTCGCAATTTTGGTATTTTTACTCTCAT
TTTCTCAGCCATGACTTTGATTATCATTCAGGTGATGCGCTCAAGCCTTTATACAACGGTCGATAATAACTTGAAAAGTC
TCAGTCAGGATTCCGCTTCTGTCATCAATTTGGCGCTCGCTCGGAGAGTGGGGATGGAACAGAAGTCAGACAACGGAGAG
CCTAAAACCGACACGGGTGACAAAGAGCTTACTGATAAACCAAATGTCAGTGCCAATACGGAAGTTATTTTATTTGATAA
GAATTATAAGCCAATCATTACAAGCAATAATTTTCTGGGACTTAATAAACTTTCCTTTAATAGCAAGCAATTGGATCGCA
TTCGGCAAGTCCAGGTTAAAAGCAATTATGGTCGACAAGAAACCTATCGGATGATTTTATTTGAAGTGAAAATCCCAAAT
TTGGAAACCAATGTCAAATATGCAGCGGTCTTTATCAATATCAGTCAGTTGGAACAAACTAGTCAAAATCATGAGCAGCT
GATTGTAGTTGTGATGATTAGTTTCTGGGGAATTTCCTTGATTGCCAGTGTCTATCTGGCTCGAGTTAGTGTTAAACCTT
TGTTGGAAAGCATTCAAAAGCAAAAGAGTTTTGTCGAAAATGCCAGTCATGAGTTGCGCACGCCTCTAGCTGTTTTACAA
AATCGTTTGGAGACTTTGTTTAGAAAACCAGAAGCCACCATTATGGAATCAAGCGAAAGCATTGCTTCTAGTTTGGATGA
AGTGCGGAACATGAAAATGTTGACGACAAATCTGCTTAATCTAGCACGGCGTGACGACGGGATTAAACCAGAAATTGGCG
ATGTCGAGCCAAATTTCTTTAATACGACCTTTACCAACTATGAAATGGTTGCCGCAGAAAATGGGAAAACTTTCCGATTT
GACAATAGGATTCACCGCATGATTAAAACAGACAAGACCTTGCTGAAGCAATTAATGACGATTCTGTTTGACAATGCTCT
GAAATATACAGATGAAGACGGTGTGATTGAATTGACAATCTCTGCAAATGATCGAAATTTGTTTTTAAAGGTTTCAGATA
ATGGTCCGGGGATTAGTACGGCAGATAAGAAAAAGATTTTTGATCGTTTTTATCGGGTTGATAAAGCACGGACTCGGCAG
ACAGGTGGTTTTGGTCTAGGCTTGTCGCTTGCAAAGCAAATCACAGAAGCTCTTAAAGGAACTATTACGGTGAAAGATAA
TAAGCCGAAAGGAACTATTTTTGAGGTGAAGATTGCCATTAGAACGGACAATAGAAAGAAAAAATAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(331-438)

His Kinase A (phospho-acceptor) domain (HisKA)

(222-287)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

71.429

100

0.714
  ciaH Streptococcus pneumoniae D39

71.429

100

0.714
  ciaH Streptococcus pneumoniae R6

71.429

100

0.714
  ciaH Streptococcus pneumoniae TIGR4

71.429

100

0.714
  ciaH Streptococcus mutans UA159

56.009

98.438

0.551