Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   PQQ25_RS10450 Genome accession   NZ_CP117242
Coordinates   2017121..2017750 (-) Length   209 a.a.
NCBI ID   WP_000153530.1    Uniprot ID   D9IFM7
Organism   Staphylococcus aureus strain ATCC 14458     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 2012121..2022750
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  PQQ25_RS10420 (PQQ25_10420) - 2012538..2013068 (-) 531 WP_000184383.1 acyl-CoA thioesterase -
  PQQ25_RS10425 (PQQ25_10425) - 2013158..2014414 (-) 1257 WP_001795438.1 aminopeptidase -
  PQQ25_RS10430 (PQQ25_10430) - 2014417..2014617 (-) 201 WP_000180461.1 DUF1128 family protein -
  PQQ25_RS10435 (PQQ25_10435) - 2014764..2015228 (+) 465 WP_000228666.1 low molecular weight protein-tyrosine-phosphatase -
  PQQ25_RS10440 (PQQ25_10440) - 2015235..2015510 (+) 276 WP_000428172.1 YtxH domain-containing protein -
  PQQ25_RS10445 (PQQ25_10445) - 2015788..2017005 (+) 1218 WP_000037075.1 YihY/virulence factor BrkB family protein -
  PQQ25_RS10450 (PQQ25_10450) vraR 2017121..2017750 (-) 630 WP_000153530.1 two-component system response regulator VraR Regulator
  PQQ25_RS10455 (PQQ25_10455) vraS 2017740..2018783 (-) 1044 WP_001017131.1 sensor histidine kinase Regulator
  PQQ25_RS10460 (PQQ25_10460) liaF 2018780..2019481 (-) 702 WP_000149064.1 cell wall-active antibiotics response protein LiaF -
  PQQ25_RS10465 (PQQ25_10465) - 2019496..2019882 (-) 387 WP_001110179.1 hypothetical protein -
  PQQ25_RS10470 (PQQ25_10470) map 2020099..2020857 (-) 759 WP_000636142.1 type I methionyl aminopeptidase -
  PQQ25_RS10475 (PQQ25_10475) - 2021385..2022371 (+) 987 WP_000999713.1 aromatic acid exporter family protein -

Sequence

Protein


Download         Length: 209 a.a.        Molecular weight: 23545.29 Da        Isoelectric Point: 5.3889

>NTDB_id=783070 PQQ25_RS10450 WP_000153530.1 2017121..2017750(-) (vraR) [Staphylococcus aureus strain ATCC 14458]
MTIKVLFVDDHEMVRIGISSYLSTQSDIEVVGEGASGKEAIAKAHELKPDLILMDLLMDDMDGVEATTQIKKDLPQIKVL
MLTSFIEDKEVYRALDAGVDSYILKTTSAKDIADAVRKTSRGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIA
KGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ

Nucleotide


Download         Length: 630 bp        

>NTDB_id=783070 PQQ25_RS10450 WP_000153530.1 2017121..2017750(-) (vraR) [Staphylococcus aureus strain ATCC 14458]
ATGACGATTAAAGTATTGTTTGTGGATGATCATGAAATGGTACGTATAGGAATTTCAAGTTATCTATCAACGCAAAGTGA
TATTGAAGTAGTTGGTGAAGGCGCTTCTGGTAAAGAAGCAATTGCCAAAGCCCATGAGTTGAAGCCAGATTTAATTTTAA
TGGATTTACTTATGGATGACATGGATGGTGTAGAAGCGACGACTCAGATTAAAAAAGATTTACCGCAAATTAAAGTATTA
ATGTTAACTAGTTTTATTGAAGATAAAGAGGTATATCGTGCATTAGATGCAGGTGTCGATAGTTACATTTTAAAAACAAC
AAGTGCAAAAGATATCGCCGATGCAGTTCGTAAAACTTCTAGAGGAGAATCTGTTTTTGAACCGGAAGTTTTAGTGAAAA
TGCGTAACCGTATGAAAAAGCGCGCAGAGTTATATGAAATGCTTACAGAACGAGAAATGGAAATATTATTATTGATTGCG
AAAGGTTACTCAAATCAAGAAATTGCTAGTGCATCGCATATTACTATTAAAACGGTTAAGACACATGTGAGTAACATTTT
AAGTAAGTTAGAAGTGCAAGATAGAACACAAGCTGTTATCTATGCATTCCAACATAATTTAATTCAATAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-116)

Bacterial regulatory proteins, luxR family (GerE)

(147-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB D9IFM7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

99.522

100

0.995
  degU Bacillus subtilis subsp. subtilis str. 168

34.821

100

0.373