Detailed information NTG0783071

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: PQQ25_RS10455
• Genome accession: NZ_CP117242
• Coordinates: 2017740..2018783 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain ATCC 14458
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2012740..2023783

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
PQQ25_RS10425 (PQQ25_10425)	-	2013158..2014414 (-)	1257	WP_001795438.1	aminopeptidase	-
PQQ25_RS10430 (PQQ25_10430)	-	2014417..2014617 (-)	201	WP_000180461.1	DUF1128 family protein	-
PQQ25_RS10435 (PQQ25_10435)	-	2014764..2015228 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
PQQ25_RS10440 (PQQ25_10440)	-	2015235..2015510 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
PQQ25_RS10445 (PQQ25_10445)	-	2015788..2017005 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
PQQ25_RS10450 (PQQ25_10450)	vraR	2017121..2017750 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
PQQ25_RS10455 (PQQ25_10455)	vraS	2017740..2018783 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
PQQ25_RS10460 (PQQ25_10460)	liaF	2018780..2019481 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
PQQ25_RS10465 (PQQ25_10465)	-	2019496..2019882 (-)	387	WP_001110179.1	hypothetical protein	-
PQQ25_RS10470 (PQQ25_10470)	map	2020099..2020857 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
PQQ25_RS10475 (PQQ25_10475)	-	2021385..2022371 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
PQQ25_RS10480 (PQQ25_10480)	-	2022802..2023215 (-)	414	WP_001549145.1	hypothetical protein	-
PQQ25_RS10485 (PQQ25_10485)	-	2023244..2023354 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=783071 PQQ25_RS10455 WP_001017131.1 2017740..2018783(-) (vraS) [Staphylococcus aureus strain ATCC 14458]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=783071 PQQ25_RS10455 WP_001017131.1 2017740..2018783(-) (vraS) [Staphylococcus aureus strain ATCC 14458]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1