Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   OTB22_RS08075 Genome accession   NZ_CP113267
Coordinates   1590471..1591208 (-) Length   245 a.a.
NCBI ID   WP_219569151.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain BC2     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1585471..1596208
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  OTB22_RS08055 (OTB22_08060) comA/nlmT 1585846..1587489 (+) 1644 WP_317657564.1 peptide cleavage/export ABC transporter Regulator
  OTB22_RS08060 (OTB22_08065) - 1587500..1588861 (+) 1362 Protein_1605 bacteriocin secretion accessory protein -
  OTB22_RS08065 (OTB22_08070) blpC 1588918..1589046 (+) 129 WP_000358815.1 quorum-sensing system pheromone BlpC -
  OTB22_RS08070 (OTB22_08075) - 1589117..1590457 (-) 1341 WP_001017646.1 sensor histidine kinase -
  OTB22_RS08075 (OTB22_08080) comE/blpR 1590471..1591208 (-) 738 WP_219569151.1 response regulator transcription factor Regulator
  OTB22_RS08080 (OTB22_08085) - 1591213..1591551 (-) 339 WP_000682133.1 LytTR family DNA-binding domain-containing protein -
  OTB22_RS08085 (OTB22_08090) - 1591828..1592157 (+) 330 WP_000132572.1 hypothetical protein -
  OTB22_RS08090 (OTB22_08095) - 1592325..1593374 (-) 1050 WP_000653771.1 ABC transporter permease -
  OTB22_RS08095 (OTB22_08100) pptA 1593371..1594102 (-) 732 WP_001866897.1 ABC transporter ATP-binding protein Regulator
  OTB22_RS08100 (OTB22_08105) - 1594170..1594580 (+) 411 WP_001278301.1 HIT family protein -
  OTB22_RS08105 (OTB22_08110) - 1594590..1594877 (+) 288 WP_268217887.1 hypothetical protein -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28786.98 Da        Isoelectric Point: 6.4147

>NTDB_id=761488 OTB22_RS08075 WP_219569151.1 1590471..1591208(-) (comE/blpR) [Streptococcus pneumoniae strain BC2]
MRIFVLEDDFSQQTRIETTIEKLLKEHHITLSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANGQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INKLH

Nucleotide


Download         Length: 738 bp        

>NTDB_id=761488 OTB22_RS08075 WP_219569151.1 1590471..1591208(-) (comE/blpR) [Streptococcus pneumoniae strain BC2]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTCTTGAAGGAACA
TCATATCACTCTGAGTTCTTTTGAAGTTTTTGGTAAGCCAGATCAATTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAGGAGATGAAGGGTCTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCGTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCCTTTCGCTACCAAGTGTCTGCTCTGGA
CTATATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATGGTCAAGACA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCCCGTTATAAGGTCAGGGAAGTGTCTGAGGCC
ATCAATAAATTACACTGA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(151-241)

Response regulator receiver domain (Response_reg)

(3-122)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

53.846

100

0.543
  comE/comE1 Streptococcus equinus JB1

43.46

96.735

0.42
  comE/comE2 Streptococcus equinus JB1

38.017

98.776

0.376