NTDB

Overview

Name	comE/blpR	Type	Regulator
Locus tag	OTU47_RS11530	Genome accession	NZ_CP113115
Coordinates	2199267..2200004 (-)	Length	245 a.a.
NCBI ID	WP_050116081.1	Uniprot ID	A0A4L7JGD9
Organism	Streptococcus pneumoniae strain NP2
Function	activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 2194267..2205004

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
OTU47_RS11510 (OTU47_11510)	blpA	2195107..2196285 (+)	1179	Protein_2237	peptide cleavage/export ABC transporter BlpA	-
OTU47_RS11515 (OTU47_11515)	-	2196296..2197657 (+)	1362	WP_267750037.1	bacteriocin secretion accessory protein	-
OTU47_RS11520 (OTU47_11520)	blpC	2197714..2197842 (+)	129	WP_000358815.1	quorum-sensing system pheromone BlpC	-
OTU47_RS11525 (OTU47_11525)	-	2197913..2199253 (-)	1341	WP_001017642.1	sensor histidine kinase	-
OTU47_RS11530 (OTU47_11530)	comE/blpR	2199267..2200004 (-)	738	WP_050116081.1	response regulator transcription factor	Regulator
OTU47_RS11535 (OTU47_11535)	-	2200009..2200347 (-)	339	WP_047499348.1	LytTR family DNA-binding domain-containing protein	-
OTU47_RS11540 (OTU47_11540)	-	2200624..2200935 (+)	312	WP_267750036.1	helicase BlpT	-
OTU47_RS11545 (OTU47_11545)	-	2201132..2202181 (-)	1050	WP_050116080.1	ABC transporter permease	-
OTU47_RS11550 (OTU47_11550)	pptA	2202178..2202909 (-)	732	WP_000889923.1	ABC transporter ATP-binding protein	Regulator
OTU47_RS11555 (OTU47_11555)	-	2202977..2203387 (+)	411	WP_001278301.1	HIT family protein	-
OTU47_RS11560 (OTU47_11560)	-	2203397..2203684 (+)	288	WP_000777760.1	hypothetical protein	-

Sequence

Protein

Download Length: 245 a.a. Molecular weight: 28784.92 Da Isoelectric Point: 6.2361

                                >NTDB_id=760461 OTU47_RS11530 WP_050116081.1 2199267..2200004(-) (comE/blpR) [Streptococcus pneumoniae strain NP2]

MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGDHQLFFLDIEIRNEEMKGLEVARKIRDRD

PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY

LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA

INNLH

Nucleotide

Download Length: 738 bp

                                >NTDB_id=760461 OTU47_RS11530 WP_050116081.1 2199267..2200004(-) (comE/blpR) [Streptococcus pneumoniae strain NP2]

ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA

TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCTGAAGTGCATGAGAAGGGGGACCATC

AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT

CCTTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCTTTTCGCTACCAAGTGTCTGCTTTGGA

CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA

GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT

CTCGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA

GGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA

AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCCCGTTATAAGGTCAGGGAAGTGTCTGAGGCT

ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-122)

LytTr DNA-binding domain (LytTR)

(151-241)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A0A4L7JGD9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
comE/blpR	Streptococcus mutans UA159	54.321	99.184	0.539
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	38.43	98.776	0.38

Detailed information NTG0760461