Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | OS078_RS03760 | Genome accession | NZ_CP113015 |
| Coordinates | 717125..718471 (-) | Length | 448 a.a. |
| NCBI ID | WP_000816499.1 | Uniprot ID | Q9R3W9 |
| Organism | Staphylococcus aureus strain Zed | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 647431..718471 | 717125..718471 | within | 0 |
Gene organization within MGE regions
Location: 647431..718471
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OS078_RS03390 | ccrB | 647431..649056 (-) | 1626 | WP_031926267.1 | cassette chromosome recombinase CcrB | Machinery gene |
| OS078_RS03395 | ccrA | 649078..650427 (-) | 1350 | WP_031926268.1 | cassette chromosome recombinase CcrA | Machinery gene |
| OS078_RS03400 | cch1 | 650615..652385 (-) | 1771 | Protein_637 | cassette chromosome replicative helicase | - |
| OS078_RS03405 | ssb | 652385..652681 (-) | 297 | WP_000220590.1 | cassette chromosome ssDNA-binding protein | - |
| OS078_RS03410 | - | 652855..654369 (-) | 1515 | WP_037541412.1 | hypothetical protein | - |
| OS078_RS03415 | - | 654514..655218 (+) | 705 | WP_016170663.1 | FRG domain-containing protein | - |
| OS078_RS03420 | tirS | 655242..656084 (+) | 843 | WP_000114516.1 | NAD(+) hydrolase TirS | - |
| OS078_RS03425 | - | 656558..656836 (+) | 279 | WP_001837210.1 | hypothetical protein | - |
| OS078_RS03430 | - | 656946..657104 (+) | 159 | WP_023604766.1 | hypothetical protein | - |
| OS078_RS03435 | - | 657422..658061 (+) | 640 | Protein_644 | fusidic acid resistance EF-G-binding protein FusC | - |
| OS078_RS03440 | - | 658748..659377 (+) | 630 | WP_001053440.1 | hypothetical protein | - |
| OS078_RS03445 | - | 660056..660484 (-) | 429 | WP_001011132.1 | VOC family protein | - |
| OS078_RS03450 | - | 660564..661494 (+) | 931 | Protein_647 | helix-turn-helix transcriptional regulator | - |
| OS078_RS03455 | - | 661909..662160 (+) | 252 | WP_001823322.1 | hypothetical protein | - |
| OS078_RS03460 | - | 662358..663221 (+) | 864 | WP_000680579.1 | LEM-3-like GIY-YIG domain-containing protein | - |
| OS078_RS03465 | - | 663329..664803 (+) | 1475 | Protein_650 | DUF6038 family protein | - |
| OS078_RS03470 | - | 665030..666130 (+) | 1101 | WP_000449985.1 | DNA polymerase | - |
| OS078_RS03475 | - | 666123..666494 (+) | 372 | WP_001058157.1 | hypothetical protein | - |
| OS078_RS03480 | - | 666491..668134 (+) | 1644 | WP_267789990.1 | DUF5906 domain-containing protein | - |
| OS078_RS03485 | ccrC | 668359..670044 (+) | 1686 | WP_000676600.1 | cassette chromosome recombinase CcrC | - |
| OS078_RS03490 | tnpA | 670092..670577 (+) | 486 | WP_000093392.1 | IS200/IS605 family transposase | - |
| OS078_RS03495 | - | 670869..671207 (+) | 339 | WP_000175892.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| OS078_RS03500 | - | 671301..671612 (+) | 312 | WP_001166716.1 | DUF960 family protein | - |
| OS078_RS03505 | - | 671628..672134 (+) | 507 | WP_000848380.1 | DUF1643 domain-containing protein | - |
| OS078_RS03510 | - | 672155..672472 (+) | 318 | WP_023180038.1 | JAB domain-containing protein | - |
| OS078_RS03515 | - | 672591..673676 (+) | 1086 | WP_000868132.1 | tyrosine-type recombinase/integrase | - |
| OS078_RS03520 | - | 673673..675565 (+) | 1893 | Protein_661 | site-specific integrase | - |
| OS078_RS03525 | - | 675572..675949 (+) | 378 | WP_000361059.1 | DUF6262 family protein | - |
| OS078_RS03530 | - | 676100..676882 (+) | 783 | WP_000067268.1 | aminoglycoside nucleotidyltransferase ANT(9)-Ia | - |
| OS078_RS03535 | erm(A) | 677008..677739 (-) | 732 | WP_001072201.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) | - |
| OS078_RS15820 | - | 677797..677853 (-) | 57 | WP_418896071.1 | erythromycin resistance leader peptide | - |
| OS078_RS03540 | - | 678245..678907 (+) | 663 | WP_001092058.1 | class I SAM-dependent methyltransferase | - |
| OS078_RS03545 | - | 679139..679285 (+) | 147 | Protein_667 | JAB domain-containing protein | - |
| OS078_RS03550 | - | 679455..680327 (+) | 873 | WP_000373151.1 | HTH domain-containing protein | - |
| OS078_RS03555 | - | 680384..680674 (+) | 291 | WP_000065262.1 | hypothetical protein | - |
| OS078_RS03560 | - | 680690..681178 (+) | 489 | WP_000397419.1 | hypothetical protein | - |
| OS078_RS03565 | - | 681313..681840 (+) | 528 | WP_000717928.1 | hypothetical protein | - |
| OS078_RS03570 | - | 681903..682319 (+) | 417 | WP_000941331.1 | hypothetical protein | - |
| OS078_RS03575 | - | 682608..682772 (+) | 165 | WP_001803222.1 | hypothetical protein | - |
| OS078_RS03580 | - | 682786..683007 (+) | 222 | WP_001070883.1 | hypothetical protein | - |
| OS078_RS03585 | - | 683157..683723 (+) | 567 | WP_000759939.1 | PepSY domain-containing protein | - |
| OS078_RS03590 | - | 683803..686016 (-) | 2214 | Protein_676 | type I restriction endonuclease subunit R | - |
| OS078_RS03595 | - | 686078..686752 (-) | 675 | WP_001105999.1 | IS6-like element IS257 family transposase | - |
| OS078_RS03600 | - | 687035..688381 (+) | 1347 | WP_064221817.1 | dihydrolipoyl dehydrogenase family protein | - |
| OS078_RS03605 | merR | 688681..689088 (+) | 408 | WP_000425271.1 | Hg(II)-responsive transcriptional regulator MerR | - |
| OS078_RS03610 | - | 689105..689458 (+) | 354 | WP_000746201.1 | TlpA family protein disulfide reductase | - |
| OS078_RS03615 | - | 689455..690135 (+) | 681 | WP_000010352.1 | cytochrome c biogenesis CcdA family protein | - |
| OS078_RS03620 | merT | 690223..690609 (+) | 387 | WP_001794630.1 | mercuric transport protein MerT | - |
| OS078_RS03625 | merA | 690667..692310 (+) | 1644 | WP_000193219.1 | mercury(II) reductase | - |
| OS078_RS03630 | merB | 692392..693042 (+) | 651 | WP_000790333.1 | organomercurial lyase MerB | - |
| OS078_RS03635 | - | 693237..693752 (-) | 516 | WP_000377078.1 | hypothetical protein | - |
| OS078_RS03640 | - | 693871..694545 (-) | 675 | WP_001105988.1 | IS6-like element IS257 family transposase | - |
| OS078_RS03645 | - | 694581..694970 (+) | 390 | WP_020444595.1 | hydroxymethylglutaryl-CoA synthase | - |
| OS078_RS03650 | - | 696047..696790 (+) | 744 | WP_000958858.1 | glycerophosphoryl diester phosphodiesterase | - |
| OS078_RS03655 | - | 696887..697315 (+) | 429 | WP_000872606.1 | MaoC family dehydratase | - |
| OS078_RS03660 | mecA | 697361..699370 (-) | 2010 | WP_267790023.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| OS078_RS03665 | mecR1 | 699467..701224 (+) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| OS078_RS03670 | mecI | 701224..701595 (+) | 372 | Protein_692 | mecA-type methicillin resistance repressor MecI | - |
| OS078_RS03675 | psm-mec | 701680..701748 (-) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| OS078_RS03680 | - | 702068..703216 (+) | 1149 | WP_000427807.1 | ROK family transcriptional regulator | - |
| OS078_RS03685 | cstB | 703330..704664 (-) | 1335 | Protein_695 | persulfide dioxygenase-sulfurtransferase CstB | - |
| OS078_RS03690 | - | 704696..705760 (-) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| OS078_RS03695 | cstR | 705896..706156 (+) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| OS078_RS03700 | - | 706156..706794 (+) | 639 | Protein_698 | sulfite exporter TauE/SafE family protein | - |
| OS078_RS03705 | - | 707068..707685 (-) | 618 | WP_000562107.1 | CadD family cadmium resistance transporter | - |
| OS078_RS03710 | - | 707766..710180 (-) | 2415 | WP_000378485.1 | cadmium-translocating P-type ATPase CadA | - |
| OS078_RS03715 | - | 710173..710538 (-) | 366 | WP_000159127.1 | ArsR/SmtB family transcription factor | - |
| OS078_RS03720 | - | 710724..711101 (-) | 378 | WP_001041908.1 | DUF6262 family protein | - |
| OS078_RS03725 | - | 711108..713000 (-) | 1893 | WP_014532403.1 | site-specific integrase | - |
| OS078_RS03730 | - | 713195..713518 (-) | 324 | WP_000088091.1 | JAB domain-containing protein | - |
| OS078_RS03735 | - | 713511..713717 (-) | 207 | WP_001077283.1 | hypothetical protein | - |
| OS078_RS03740 | - | 713719..714240 (-) | 522 | WP_000836008.1 | DUF1643 domain-containing protein | - |
| OS078_RS03745 | - | 714259..714570 (-) | 312 | WP_000833212.1 | DUF960 family protein | - |
| OS078_RS03750 | - | 714655..715005 (-) | 351 | WP_000171449.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| OS078_RS03755 | ccrB | 715476..717104 (-) | 1629 | WP_001186596.1 | cassette chromosome recombinase CcrB | Machinery gene |
| OS078_RS03760 | ccrA | 717125..718471 (-) | 1347 | WP_000816499.1 | cassette chromosome recombinase CcrA | Machinery gene |
Sequence
Protein
Download Length: 448 a.a. Molecular weight: 52138.19 Da Isoelectric Point: 10.1760
>NTDB_id=759050 OS078_RS03760 WP_000816499.1 717125..718471(-) (ccrA) [Staphylococcus aureus strain Zed]
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA
Nucleotide
Download Length: 1347 bp
>NTDB_id=759050 OS078_RS03760 WP_000816499.1 717125..718471(-) (ccrA) [Staphylococcus aureus strain Zed]
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus COL |
78.174 |
100 |
0.783 |
| ccrA | Staphylococcus aureus N315 |
72.383 |
100 |
0.725 |