Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   MRSL_RS05610 Genome accession   NZ_AP021848
Coordinates   1194765..1195394 (+) Length   209 a.a.
NCBI ID   WP_002461333.1    Uniprot ID   -
Organism   Staphylococcus lugdunensis strain JICS135     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1189765..1200394
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MRSL_RS05585 (MRSL_11250) - 1190517..1191497 (-) 981 WP_002492696.1 FUSC family protein -
  MRSL_RS05590 (MRSL_11260) map 1191742..1192497 (+) 756 WP_002461338.1 type I methionyl aminopeptidase -
  MRSL_RS05595 (MRSL_11270) - 1192623..1193009 (+) 387 WP_002477960.1 hypothetical protein -
  MRSL_RS05600 (MRSL_11280) liaF 1193034..1193735 (+) 702 WP_002461335.1 cell wall-active antibiotics response protein LiaF -
  MRSL_RS05605 (MRSL_11290) vraS 1193732..1194775 (+) 1044 WP_002461334.1 sensor histidine kinase Regulator
  MRSL_RS05610 (MRSL_11300) vraR 1194765..1195394 (+) 630 WP_002461333.1 two-component system response regulator VraR Regulator
  MRSL_RS05615 (MRSL_11310) - 1195567..1196796 (-) 1230 WP_002492699.1 YihY/virulence factor BrkB family protein -
  MRSL_RS05620 (MRSL_11320) - 1196999..1197283 (-) 285 WP_002461330.1 YtxH domain-containing protein -
  MRSL_RS05625 (MRSL_11330) - 1197290..1197754 (-) 465 WP_002492719.1 low molecular weight protein-tyrosine-phosphatase -
  MRSL_RS05630 (MRSL_11340) - 1197918..1198103 (+) 186 WP_002492715.1 DUF1128 domain-containing protein -
  MRSL_RS05635 (MRSL_11350) - 1198116..1199354 (+) 1239 WP_002461326.1 aminopeptidase -
  MRSL_RS05640 (MRSL_11360) - 1199388..1199915 (+) 528 WP_002461325.1 acyl-CoA thioesterase -

Sequence

Protein


Download         Length: 209 a.a.        Molecular weight: 23658.47 Da        Isoelectric Point: 5.3841

>NTDB_id=74984 MRSL_RS05610 WP_002461333.1 1194765..1195394(+) (vraR) [Staphylococcus lugdunensis strain JICS135]
MTIKVLFVDDHEMVRIGISSYLSTQPDLEVVGEGASGKEAIAKAQELKPDLILMDLLMEDMDGVEATTQIKKEMPHIKVV
MLTSFIEDKEVYRALDAGVDSYILKTTSAKDIAEAVRKTYHGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIA
KGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ

Nucleotide


Download         Length: 630 bp        

>NTDB_id=74984 MRSL_RS05610 WP_002461333.1 1194765..1195394(+) (vraR) [Staphylococcus lugdunensis strain JICS135]
ATGACAATTAAAGTACTATTTGTAGATGACCATGAAATGGTAAGAATAGGAATTTCTAGTTATTTATCTACTCAACCAGA
CCTTGAAGTTGTAGGTGAAGGTGCTTCTGGTAAAGAGGCAATAGCTAAAGCACAAGAATTAAAGCCAGATTTAATCTTGA
TGGATTTATTAATGGAAGACATGGATGGCGTCGAAGCGACAACACAAATCAAGAAAGAGATGCCTCATATTAAAGTTGTA
ATGCTGACTAGCTTTATTGAGGATAAAGAAGTATATAGAGCGTTAGACGCTGGTGTTGACAGCTATATTTTAAAAACAAC
AAGCGCTAAAGATATCGCTGAAGCAGTGCGCAAAACATATCATGGAGAATCTGTATTTGAACCGGAAGTTCTGGTAAAAA
TGCGAAATAGAATGAAAAAACGTGCAGAGCTATATGAAATGTTAACAGAACGAGAAATGGAAATTTTACTGTTAATTGCT
AAAGGATATTCTAATCAAGAAATCGCAAGCGCATCACACATTACTATTAAAACAGTTAAAACACATGTGAGTAATATTTT
AAGCAAATTAGAAGTACAAGACCGTACACAAGCAGTAATCTATGCATTTCAGCATAATCTTATTCAATAA

Domains

Predicted by InterproScan.

Bacterial regulatory proteins, luxR family (GerE)

(147-202)

Response regulator receiver domain (Response_reg)

(5-116)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

95.215

100

0.952
  degU Bacillus subtilis subsp. subtilis str. 168

35.714

100

0.383

Multiple sequence alignment