Detailed information NTG0074983

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: MRSL_RS05605
• Genome accession: NZ_AP021848
• Coordinates: 1193732..1194775 (+)
• Length: 347 a.a.
• NCBI ID: WP_002461334.1
• Uniprot ID: A0A853V5Y6
• Organism: Staphylococcus lugdunensis strain JICS135
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1188732..1199775

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MRSL_RS05580 (MRSL_11240)	-	1189022..1190383 (-)	1362	WP_037540479.1	FAD-dependent oxidoreductase	-
MRSL_RS05585 (MRSL_11250)	-	1190517..1191497 (-)	981	WP_002492696.1	FUSC family protein	-
MRSL_RS05590 (MRSL_11260)	map	1191742..1192497 (+)	756	WP_002461338.1	type I methionyl aminopeptidase	-
MRSL_RS05595 (MRSL_11270)	-	1192623..1193009 (+)	387	WP_002477960.1	hypothetical protein	-
MRSL_RS05600 (MRSL_11280)	liaF	1193034..1193735 (+)	702	WP_002461335.1	cell wall-active antibiotics response protein LiaF	-
MRSL_RS05605 (MRSL_11290)	vraS	1193732..1194775 (+)	1044	WP_002461334.1	sensor histidine kinase	Regulator
MRSL_RS05610 (MRSL_11300)	vraR	1194765..1195394 (+)	630	WP_002461333.1	two-component system response regulator VraR	Regulator
MRSL_RS05615 (MRSL_11310)	-	1195567..1196796 (-)	1230	WP_002492699.1	YihY/virulence factor BrkB family protein	-
MRSL_RS05620 (MRSL_11320)	-	1196999..1197283 (-)	285	WP_002461330.1	YtxH domain-containing protein	-
MRSL_RS05625 (MRSL_11330)	-	1197290..1197754 (-)	465	WP_002492719.1	low molecular weight protein-tyrosine-phosphatase	-
MRSL_RS05630 (MRSL_11340)	-	1197918..1198103 (+)	186	WP_002492715.1	DUF1128 domain-containing protein	-
MRSL_RS05635 (MRSL_11350)	-	1198116..1199354 (+)	1239	WP_002461326.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 39934.41 Da
• Isoelectric Point: 5.9679

>NTDB_id=74983 MRSL_RS05605 WP_002461334.1 1193732..1194775(+) (vraS) [Staphylococcus lugdunensis strain JICS135]
MNHYIRAIGSMLILVYSLMIAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLVIILLCIIVGSILAFKINQQNDWIKT
QVEHAIEGETVGINDQNIELYNETIDLYHTLVPLNQELHRLRMKTQNLTNENYNLNDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETELEPPLDQQIPVLEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHDI
EEFKVPKGLEDHLFRITQEAISNTLRHSKGTKVTVELFNKADYLLLRIQDNGIGFNVDDKVEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSHDN

Nucleotide

• Length: 1044 bp

>NTDB_id=74983 MRSL_RS05605 WP_002461334.1 1193732..1194775(+) (vraS) [Staphylococcus lugdunensis strain JICS135]
ATGAACCACTATATTCGAGCAATCGGCTCAATGTTGATACTAGTGTATAGCTTAATGATTGCTTTTCTGTTTATTGATAA
AGTATTCGTTAATATCATTTACTTTCAAGGCATGTTTTATACACAAATATTTGGAATACCAGTATTCCTTTTCTTAAATT
TGGTTATTATTTTATTATGTATTATTGTGGGCTCTATATTAGCTTTTAAAATCAATCAACAAAATGATTGGATCAAAACA
CAAGTAGAGCATGCAATAGAAGGGGAAACAGTTGGTATAAATGATCAAAATATAGAATTGTATAATGAAACAATTGATTT
ATATCATACATTAGTTCCCTTAAATCAAGAGTTACACCGATTAAGAATGAAAACACAAAACTTAACAAATGAAAATTATA
ATTTAAATGATGTAAAAGTGAAAAAAATAATTGAAGACGAACGTCAACGTCTAGCTCGAGAATTACATGATTCAGTGAGC
CAGCAATTATTTGCAGCCAGTATGATGTTATCTGCAATTAAAGAAACAGAGCTAGAACCACCTTTAGATCAACAAATTCC
AGTTTTAGAAAAAATGGTGCAAGATTCACAACTTGAAATGAGAGCACTCTTATTACATCTAAGACCAATTGGTTTAAAGG
ACAAGTCGTTGGGTGAAGGTATTAAAGATTTAGTCATCGATTTACAGAAAAAAGTACCGATGAAAGTGGTTCACGATATT
GAAGAATTTAAAGTGCCTAAAGGTTTAGAAGATCATTTGTTTAGAATTACTCAAGAAGCCATCTCTAATACTTTAAGACA
TTCAAAAGGAACTAAAGTTACTGTAGAATTATTTAATAAAGCAGATTATTTATTATTAAGAATACAAGATAATGGCATTG
GATTTAATGTTGATGATAAAGTCGAACAAAGTTATGGCTTGAAAAATATGCGCGAACGTGCGTTAGAAATAGGTGCAACA
TTTCATATTGTATCATTGCCTGATTCTGGAACAAGAATAGAGGTTAAAGCACCGTTAAACAAGGAGGATTCACATGACAA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A853V5Y6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	91.066	100	0.911