NTDB

Overview

Name	ciaH	Type	Regulator
Locus tag	N2A95_RS07140	Genome accession	NZ_CP104190
Coordinates	1416664..1417968 (-)	Length	434 a.a.
NCBI ID	WP_003108419.1	Uniprot ID	A0A2I8ALC4
Organism	Streptococcus parauberis strain HFTC0064
Function	Required for optimal comC expression (predicted from homology) Competence regulation

Genomic Context

Location: 1411664..1422968

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
N2A95_RS07110 (N2A95_07110)	-	1412186..1412575 (-)	390	WP_003108421.1	cytidine deaminase	-
N2A95_RS07115 (N2A95_07115)	deoC	1412562..1413224 (-)	663	WP_003103647.1	deoxyribose-phosphate aldolase	-
N2A95_RS07120 (N2A95_07120)	-	1413238..1414515 (-)	1278	WP_003102832.1	pyrimidine-nucleoside phosphorylase	-
N2A95_RS07125 (N2A95_07125)	-	1414502..1415101 (-)	600	WP_003103028.1	class I SAM-dependent methyltransferase	-
N2A95_RS07130 (N2A95_07130)	coaA	1415352..1416272 (+)	921	WP_003108420.1	type I pantothenate kinase	-
N2A95_RS07135 (N2A95_07135)	rpsT	1416341..1416574 (+)	234	WP_003105398.1	30S ribosomal protein S20	-
N2A95_RS07140 (N2A95_07140)	ciaH	1416664..1417968 (-)	1305	WP_003108419.1	cell wall metabolism sensor histidine kinase WalK	Regulator
N2A95_RS07145 (N2A95_07145)	ciaR	1417961..1418635 (-)	675	WP_003104260.1	response regulator transcription factor	Regulator
N2A95_RS07150 (N2A95_07150)	-	1418756..1421293 (-)	2538	WP_037619666.1	M1 family metallopeptidase	-
N2A95_RS07155 (N2A95_07155)	phoU	1421357..1422010 (-)	654	WP_003103398.1	phosphate signaling complex protein PhoU	-
N2A95_RS07160 (N2A95_07160)	pstB	1422076..1422834 (-)	759	WP_003104047.1	phosphate ABC transporter ATP-binding protein PstB	-

Sequence

Protein

Download Length: 434 a.a. Molecular weight: 49729.10 Da Isoelectric Point: 9.1102

                                >NTDB_id=727954 N2A95_RS07140 WP_003108419.1 1416664..1417968(-) (ciaH) [Streptococcus parauberis strain HFTC0064]

MNKIKLFLKSGSFDHFFHFFTVFTSIFVIMTFIILQIMRFGVYSTVDNSLNLVAKHSTLYADKAMEQISLFNFDNQNFNE

ATSRYKSSLITDPVGNTDIILYSADGTILNPFDAFSNLNYFKLNPHQLNKIVTQKKTNFYGHEEKFHTVTIKVQSNNYPA

VSYLSAVANVDQLDRANERYENIIILVMSIFWLISIFASIYLAYWSRKPIVESFEKQKSFVENASHELRTPLAVLQNRLE

SLFRKPNETILENSEAIASSLEEVRNMRILTTNLLNLARRDDGIDVKKEEIGASFFEPIFENYKLIAEENGIKFQSFNEV

SYKFVTDKALLKQLITILFDNAVKYTAENGNIVILVKTTEKSLLLRVSDNGIGISNSDKERIFDRFYRVDKARTRQIGGF

GLGLALAKQIVVTLKGDITVKDNFPQGTIFQVKL

Nucleotide

Download Length: 1305 bp

                                >NTDB_id=727954 N2A95_RS07140 WP_003108419.1 1416664..1417968(-) (ciaH) [Streptococcus parauberis strain HFTC0064]

ATGAATAAGATAAAATTATTTTTAAAGTCAGGGAGCTTTGATCATTTCTTTCATTTCTTCACTGTTTTTACAAGTATTTT

TGTTATTATGACTTTTATCATATTACAAATTATGCGCTTTGGTGTCTATTCAACAGTTGATAATAGTTTGAATCTTGTTG

CAAAACACTCTACTCTTTATGCTGATAAAGCGATGGAACAGATTTCACTCTTTAATTTTGATAATCAGAATTTTAATGAA

GCGACGAGTCGCTATAAGTCATCTTTGATTACTGATCCTGTTGGTAATACTGACATTATCTTATATAGTGCTGATGGAAC

AATTTTAAATCCCTTTGATGCTTTTTCAAACTTAAATTATTTTAAATTAAATCCACATCAACTTAATAAGATAGTTACCC

AAAAAAAAACAAATTTTTACGGACATGAAGAAAAGTTTCATACTGTCACCATTAAAGTTCAATCAAATAATTATCCTGCC

GTTTCTTATCTCAGTGCGGTGGCAAATGTTGACCAACTTGATCGGGCTAATGAGCGGTATGAGAATATTATTATATTGGT

TATGAGTATCTTTTGGTTAATTTCCATTTTTGCAAGTATCTATTTAGCTTATTGGAGTCGAAAACCTATTGTTGAGAGTT

TTGAAAAGCAGAAGTCATTTGTTGAAAATGCTAGTCATGAATTAAGGACGCCTTTGGCTGTGTTACAAAATCGCTTAGAA

TCTTTGTTTAGGAAGCCAAACGAGACTATCTTAGAGAATAGCGAAGCCATTGCTTCAAGTCTTGAAGAAGTAAGAAACAT

GCGTATTTTGACGACTAATCTCCTAAATTTAGCTAGACGAGATGATGGGATTGATGTAAAGAAAGAAGAAATTGGCGCTT

CATTCTTTGAGCCTATTTTTGAAAATTATAAGCTAATTGCGGAAGAAAATGGGATAAAATTTCAATCATTTAACGAAGTT

TCCTATAAATTTGTCACTGATAAAGCTTTGTTAAAACAATTAATAACCATCTTATTTGATAATGCTGTGAAATATACAGC

TGAAAATGGGAATATTGTAATCCTCGTTAAAACGACTGAGAAATCACTCTTACTTCGTGTTAGTGATAATGGCATAGGAA

TTTCTAATTCAGATAAAGAGAGAATTTTTGATCGCTTTTATCGGGTTGATAAAGCTAGGACGCGTCAAATTGGTGGATTC

GGTCTAGGCCTAGCATTAGCTAAACAGATTGTGGTCACTTTAAAAGGTGATATTACAGTCAAAGATAATTTTCCTCAAGG

AACAATTTTTCAGGTCAAATTATAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(327-434)

His Kinase A (phospho-acceptor) domain (HisKA)

(218-283)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A0A2I8ALC4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
ciaH	Streptococcus mutans UA159	56.161	97.235	0.546
ciaH	Streptococcus pneumoniae Rx1	50	100	0.505
ciaH	Streptococcus pneumoniae D39	50	100	0.505
ciaH	Streptococcus pneumoniae R6	50	100	0.505
ciaH	Streptococcus pneumoniae TIGR4	50	100	0.505

Detailed information NTG0727954