Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   NW945_RS09370 Genome accession   NZ_CP102974
Coordinates   1923900..1924529 (-) Length   209 a.a.
NCBI ID   WP_000153536.1    Uniprot ID   A0A481NSD5
Organism   Staphylococcus aureus strain 01-RR-86     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1918900..1929529
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NW945_RS09340 (NW945_09340) - 1919321..1919851 (-) 531 WP_000184383.1 acyl-CoA thioesterase -
  NW945_RS09345 (NW945_09345) - 1919941..1921197 (-) 1257 WP_001789555.1 aminopeptidase -
  NW945_RS09350 (NW945_09350) - 1921200..1921400 (-) 201 WP_000180460.1 DUF1128 family protein -
  NW945_RS09355 (NW945_09355) - 1921547..1922011 (+) 465 WP_000228666.1 low molecular weight protein-tyrosine-phosphatase -
  NW945_RS09360 (NW945_09360) - 1922018..1922293 (+) 276 WP_000428171.1 hypothetical protein -
  NW945_RS09365 (NW945_09365) - 1922571..1923788 (+) 1218 WP_000037079.1 YihY/virulence factor BrkB family protein -
  NW945_RS09370 (NW945_09370) vraR 1923900..1924529 (-) 630 WP_000153536.1 two-component system response regulator VraR Regulator
  NW945_RS09375 (NW945_09375) vraS 1924519..1925562 (-) 1044 WP_001017131.1 sensor histidine kinase Regulator
  NW945_RS09380 (NW945_09380) liaF 1925559..1926260 (-) 702 WP_000149064.1 cell wall-active antibiotics response protein LiaF -
  NW945_RS09385 (NW945_09385) - 1926275..1926661 (-) 387 WP_001110179.1 hypothetical protein -
  NW945_RS09390 (NW945_09390) map 1926878..1927636 (-) 759 WP_000636138.1 type I methionyl aminopeptidase -
  NW945_RS09395 (NW945_09395) - 1928166..1929152 (+) 987 WP_000999716.1 aromatic acid exporter family protein -

Sequence

Protein


Download         Length: 209 a.a.        Molecular weight: 23490.21 Da        Isoelectric Point: 5.1703

>NTDB_id=720969 NW945_RS09370 WP_000153536.1 1923900..1924529(-) (vraR) [Staphylococcus aureus strain 01-RR-86]
MTIKVLFVDDHEMVRIGISSYLSTQSDIEVVGEGASGKEAIAKAHELKPDLILMDLLMEDMDGVEATTQIKKDLPQIKVL
MLTSFIEDKEVYRALDAGVDSYILKTTSAKDIADAVRKTSSGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIA
KGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ

Nucleotide


Download         Length: 630 bp        

>NTDB_id=720969 NW945_RS09370 WP_000153536.1 1923900..1924529(-) (vraR) [Staphylococcus aureus strain 01-RR-86]
ATGACGATTAAAGTATTGTTTGTGGATGATCATGAAATGGTACGTATAGGAATTTCAAGTTATCTATCAACGCAAAGTGA
TATTGAAGTAGTTGGTGAAGGCGCTTCTGGTAAGGAAGCAATTGCCAAAGCCCATGAGTTGAAGCCAGATTTAATTTTAA
TGGATTTACTTATGGAAGACATGGATGGTGTAGAAGCGACGACTCAGATTAAAAAAGATTTACCGCAAATTAAAGTATTA
ATGTTAACTAGTTTTATTGAAGATAAAGAGGTATATCGTGCATTAGATGCAGGTGTCGATAGTTACATTTTAAAAACAAC
AAGTGCAAAAGATATCGCCGATGCAGTTCGTAAAACTTCTAGCGGAGAATCTGTTTTTGAACCGGAAGTTTTAGTGAAAA
TGCGTAACCGTATGAAAAAGCGCGCAGAGTTATATGAAATGCTTACAGAACGAGAAATGGAAATATTATTATTGATTGCG
AAAGGTTACTCAAATCAAGAAATTGCTAGTGCATCGCATATTACTATTAAAACGGTTAAGACACATGTGAGTAACATTTT
AAGTAAGTTAGAAGTGCAAGATAGAACACAAGCTGTCATCTATGCATTCCAACATAATTTAATTCAATAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-116)

Bacterial regulatory proteins, luxR family (GerE)

(147-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A481NSD5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

99.522

100

0.995
  degU Bacillus subtilis subsp. subtilis str. 168

34.821

100

0.373