Detailed information NTG0720970

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: NW945_RS09375
• Genome accession: NZ_CP102974
• Coordinates: 1924519..1925562 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 01-RR-86
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1919519..1930562

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
NW945_RS09345 (NW945_09345)	-	1919941..1921197 (-)	1257	WP_001789555.1	aminopeptidase	-
NW945_RS09350 (NW945_09350)	-	1921200..1921400 (-)	201	WP_000180460.1	DUF1128 family protein	-
NW945_RS09355 (NW945_09355)	-	1921547..1922011 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
NW945_RS09360 (NW945_09360)	-	1922018..1922293 (+)	276	WP_000428171.1	hypothetical protein	-
NW945_RS09365 (NW945_09365)	-	1922571..1923788 (+)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
NW945_RS09370 (NW945_09370)	vraR	1923900..1924529 (-)	630	WP_000153536.1	two-component system response regulator VraR	Regulator
NW945_RS09375 (NW945_09375)	vraS	1924519..1925562 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
NW945_RS09380 (NW945_09380)	liaF	1925559..1926260 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
NW945_RS09385 (NW945_09385)	-	1926275..1926661 (-)	387	WP_001110179.1	hypothetical protein	-
NW945_RS09390 (NW945_09390)	map	1926878..1927636 (-)	759	WP_000636138.1	type I methionyl aminopeptidase	-
NW945_RS09395 (NW945_09395)	-	1928166..1929152 (+)	987	WP_000999716.1	aromatic acid exporter family protein	-
NW945_RS09400 (NW945_09400)	-	1929525..1929938 (-)	414	WP_001566709.1	hypothetical protein	-
NW945_RS09405 (NW945_09405)	-	1929967..1930041 (-)	75	Protein_1814	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=720970 NW945_RS09375 WP_001017131.1 1924519..1925562(-) (vraS) [Staphylococcus aureus strain 01-RR-86]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=720970 NW945_RS09375 WP_001017131.1 1924519..1925562(-) (vraS) [Staphylococcus aureus strain 01-RR-86]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTGGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGTTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1