Detailed information NTG0720928

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: NW963_RS09755
• Genome accession: NZ_CP102972
• Coordinates: 1979912..1980955 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 05-RR-90
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1974912..1985955

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
NW963_RS09725 (NW963_09720)	-	1975332..1976588 (-)	1257	WP_078100781.1	aminopeptidase	-
NW963_RS09730 (NW963_09725)	-	1976591..1976791 (-)	201	WP_000180460.1	DUF1128 family protein	-
NW963_RS09735 (NW963_09730)	-	1976938..1977402 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
NW963_RS09740 (NW963_09735)	-	1977409..1977684 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
NW963_RS09745 (NW963_09740)	-	1977963..1979180 (+)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
NW963_RS09750 (NW963_09745)	vraR	1979293..1979922 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
NW963_RS09755 (NW963_09750)	vraS	1979912..1980955 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
NW963_RS09760 (NW963_09755)	liaF	1980952..1981653 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
NW963_RS09765 (NW963_09760)	-	1981668..1982054 (-)	387	WP_001110179.1	hypothetical protein	-
NW963_RS09770 (NW963_09765)	map	1982271..1983029 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
NW963_RS09775 (NW963_09770)	-	1983501..1984487 (+)	987	WP_258412232.1	aromatic acid exporter family protein	-
NW963_RS09780 (NW963_09775)	-	1984918..1985331 (-)	414	WP_258412090.1	hypothetical protein	-
NW963_RS09785 (NW963_09780)	-	1985360..1985470 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=720928 NW963_RS09755 WP_001017131.1 1979912..1980955(-) (vraS) [Staphylococcus aureus strain 05-RR-90]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=720928 NW963_RS09755 WP_001017131.1 1979912..1980955(-) (vraS) [Staphylococcus aureus strain 05-RR-90]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1