Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   NW973_RS09885 Genome accession   NZ_CP102961
Coordinates   2001877..2002506 (-) Length   209 a.a.
NCBI ID   WP_000153532.1    Uniprot ID   A0A481NSL0
Organism   Staphylococcus aureus strain 03-RR-88     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1996877..2007506
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NW973_RS09855 (NW973_09855) - 1997297..1997827 (-) 531 WP_000184383.1 acyl-CoA thioesterase -
  NW973_RS09860 (NW973_09860) - 1997917..1999173 (-) 1257 WP_001789555.1 aminopeptidase -
  NW973_RS09865 (NW973_09865) - 1999176..1999376 (-) 201 WP_000180460.1 DUF1128 family protein -
  NW973_RS09870 (NW973_09870) - 1999523..1999987 (+) 465 WP_000228666.1 low molecular weight protein-tyrosine-phosphatase -
  NW973_RS09875 (NW973_09875) - 1999994..2000269 (+) 276 WP_000428172.1 YtxH domain-containing protein -
  NW973_RS09880 (NW973_09880) - 2000547..2001764 (+) 1218 WP_000037079.1 YihY/virulence factor BrkB family protein -
  NW973_RS09885 (NW973_09885) vraR 2001877..2002506 (-) 630 WP_000153532.1 two-component system response regulator VraR Regulator
  NW973_RS09890 (NW973_09890) vraS 2002496..2003539 (-) 1044 WP_001017131.1 sensor histidine kinase Regulator
  NW973_RS09895 (NW973_09895) liaF 2003536..2004237 (-) 702 WP_000149064.1 cell wall-active antibiotics response protein LiaF -
  NW973_RS09900 (NW973_09900) - 2004252..2004638 (-) 387 WP_258410754.1 hypothetical protein -
  NW973_RS09905 (NW973_09905) map 2004854..2005612 (-) 759 WP_006190643.1 type I methionyl aminopeptidase -
  NW973_RS09910 (NW973_09910) - 2006142..2007128 (+) 987 WP_000999713.1 aromatic acid exporter family protein -

Sequence

Protein


Download         Length: 209 a.a.        Molecular weight: 23516.29 Da        Isoelectric Point: 5.1703

>NTDB_id=720596 NW973_RS09885 WP_000153532.1 2001877..2002506(-) (vraR) [Staphylococcus aureus strain 03-RR-88]
MTIKVLFVDDHEMVRIGISSYLSTQSDIEVVGEGASGKEAIAKAHELKPDLILMDLLMEDMDGVEATTQIKKDLPQIKVL
MLTSFIEDKEVYRALDAGVDSYILKTTSAKDIADAVRKTSIGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIA
KGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ

Nucleotide


Download         Length: 630 bp        

>NTDB_id=720596 NW973_RS09885 WP_000153532.1 2001877..2002506(-) (vraR) [Staphylococcus aureus strain 03-RR-88]
ATGACGATTAAAGTATTGTTTGTGGATGATCATGAAATGGTACGTATAGGAATTTCAAGTTATCTATCAACGCAAAGTGA
TATTGAAGTAGTTGGTGAAGGCGCTTCTGGTAAAGAAGCAATTGCCAAAGCCCATGAGTTGAAGCCAGATTTAATTTTAA
TGGATTTACTTATGGAAGACATGGATGGTGTAGAAGCGACGACTCAGATTAAAAAAGATTTACCGCAAATTAAAGTATTA
ATGTTAACTAGTTTTATTGAAGATAAAGAGGTATATCGTGCATTAGATGCAGGTGTCGATAGTTACATTTTAAAAACAAC
AAGTGCAAAAGATATCGCCGATGCAGTTCGTAAAACTTCTATAGGAGAATCTGTTTTTGAACCGGAAGTTTTAGTGAAAA
TGCGTAACCGTATGAAAAAGCGCGCAGAGTTATATGAAATGCTTACAGAACGAGAAATGGAAATATTATTATTGATTGCG
AAAGGTTACTCAAATCAAGAAATTGCTAGTGCATCGCATATTACTATTAAAACGGTTAAGACACATGTGAGTAACATTTT
AAGTAAGTTAGAAGTGCAAGATAGAACACAAGCTGTCATCTATGCATTCCAACATAATTTAATTCAATAG

Domains

Predicted by InterproScan.

Bacterial regulatory proteins, luxR family (GerE)

(147-202)

Response regulator receiver domain (Response_reg)

(5-116)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A481NSL0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

99.522

100

0.995
  degU Bacillus subtilis subsp. subtilis str. 168

34.821

100

0.373