Detailed information NTG0720597

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: NW973_RS09890
• Genome accession: NZ_CP102961
• Coordinates: 2002496..2003539 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 03-RR-88
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1997496..2008539

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
NW973_RS09860 (NW973_09860)	-	1997917..1999173 (-)	1257	WP_001789555.1	aminopeptidase	-
NW973_RS09865 (NW973_09865)	-	1999176..1999376 (-)	201	WP_000180460.1	DUF1128 family protein	-
NW973_RS09870 (NW973_09870)	-	1999523..1999987 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
NW973_RS09875 (NW973_09875)	-	1999994..2000269 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
NW973_RS09880 (NW973_09880)	-	2000547..2001764 (+)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
NW973_RS09885 (NW973_09885)	vraR	2001877..2002506 (-)	630	WP_000153532.1	two-component system response regulator VraR	Regulator
NW973_RS09890 (NW973_09890)	vraS	2002496..2003539 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
NW973_RS09895 (NW973_09895)	liaF	2003536..2004237 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
NW973_RS09900 (NW973_09900)	-	2004252..2004638 (-)	387	WP_258410754.1	hypothetical protein	-
NW973_RS09905 (NW973_09905)	map	2004854..2005612 (-)	759	WP_006190643.1	type I methionyl aminopeptidase	-
NW973_RS09910 (NW973_09910)	-	2006142..2007128 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
NW973_RS09915 (NW973_09915)	-	2007677..2008090 (-)	414	WP_258411147.1	hypothetical protein	-
NW973_RS09920 (NW973_09920)	-	2008119..2008229 (-)	111	WP_031775032.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=720597 NW973_RS09890 WP_001017131.1 2002496..2003539(-) (vraS) [Staphylococcus aureus strain 03-RR-88]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=720597 NW973_RS09890 WP_001017131.1 2002496..2003539(-) (vraS) [Staphylococcus aureus strain 03-RR-88]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTGGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1