Detailed information    

insolico Bioinformatically predicted

Overview

Name   comFA/cflA   Type   Machinery gene
Locus tag   NQZ93_RS02140 Genome accession   NZ_CP102141
Coordinates   425503..426795 (+) Length   430 a.a.
NCBI ID   WP_024390587.1    Uniprot ID   A0A075SHM8
Organism   Streptococcus suis strain DNR48     
Function   ssDNA transport into the cell (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 420503..431795
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NQZ93_RS02115 (NQZ93_02115) - 421309..421950 (+) 642 WP_002937025.1 response regulator transcription factor -
  NQZ93_RS02120 (NQZ93_02120) - 422000..423400 (+) 1401 WP_024381714.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  NQZ93_RS02125 (NQZ93_02125) - 423402..423773 (+) 372 WP_024381713.1 S1 RNA-binding domain-containing protein -
  NQZ93_RS02130 (NQZ93_02130) cysK 423799..424725 (-) 927 WP_257115326.1 cysteine synthase A -
  NQZ93_RS02135 (NQZ93_02135) - 424814..425446 (-) 633 WP_023369489.1 YigZ family protein -
  NQZ93_RS02140 (NQZ93_02140) comFA/cflA 425503..426795 (+) 1293 WP_024390587.1 DEAD/DEAH box helicase Machinery gene
  NQZ93_RS02145 (NQZ93_02145) - 426788..427453 (+) 666 WP_023369493.1 ComF family protein -
  NQZ93_RS02150 (NQZ93_02150) hpf 427530..428072 (+) 543 WP_004194117.1 ribosome hibernation-promoting factor, HPF/YfiA family -

Sequence

Protein


Download         Length: 430 a.a.        Molecular weight: 48955.59 Da        Isoelectric Point: 9.0711

>NTDB_id=714835 NQZ93_RS02140 WP_024390587.1 425503..426795(+) (comFA/cflA) [Streptococcus suis strain DNR48]
MKELENYYGRLFTKYQLTAKEREIAEKVPSITKKNNCFRCGTTFEEENKLPNDAYYCRACLLLGRVRSDEKLYHFPQKDF
PITKCLKWKGQLTDWQQRISDGLVANVENNRATLVHAVTGAGKTEMIYHTLASVIDKGGAVCLASPRIDVCIELYKRLQN
DFSVPISLLHGESEPYFRTPLVVATTHQLLKFYQAFDLVLIDEVDAFPYADNPMLYRAADNAVKEAGVQVFLTATSTDEL
DKKVRTGKLSRLSLPRRFHGNPLIVPQKVWFSKFDDTLKKNRLVPKLKKAIEEQRKSCFPLLIFVPEISKGQEFTKIMKK
TFPEETIGFVSSQTENRLEIVEGFRKREITVLISTTILERGVTFPCVDVFVVQANHYLFTASSLVQIAGRVGRSIERPTG
LLQFYHEGSTGAIEKAIAEIKQMNKEAGYV

Nucleotide


Download         Length: 1293 bp        

>NTDB_id=714835 NQZ93_RS02140 WP_024390587.1 425503..426795(+) (comFA/cflA) [Streptococcus suis strain DNR48]
ATGAAAGAATTAGAAAATTATTACGGTAGATTATTTACCAAATACCAATTGACAGCAAAAGAAAGAGAAATAGCAGAAAA
AGTGCCAAGTATTACAAAAAAGAATAACTGCTTTCGCTGTGGAACAACTTTTGAAGAAGAAAACAAATTGCCAAACGATG
CTTATTACTGTCGAGCCTGCTTGCTTCTAGGCAGAGTGCGGTCAGACGAAAAACTCTATCATTTTCCTCAGAAAGATTTT
CCAATCACTAAGTGTTTAAAGTGGAAAGGTCAACTAACTGATTGGCAACAAAGAATTTCAGATGGACTAGTTGCAAACGT
GGAAAACAATCGTGCGACATTGGTTCATGCAGTAACAGGAGCAGGTAAGACAGAAATGATCTACCACACCCTTGCCTCAG
TGATTGATAAAGGCGGAGCGGTTTGCCTAGCCAGTCCTCGAATTGATGTTTGTATCGAACTCTATAAACGTCTGCAAAAT
GACTTTTCAGTTCCAATTAGTTTACTACATGGAGAGTCTGAACCCTATTTCCGAACCCCATTAGTTGTAGCAACCACACA
TCAGTTATTAAAATTTTATCAGGCCTTTGATTTGGTTTTGATTGATGAAGTAGACGCCTTTCCCTATGCAGATAATCCCA
TGCTCTATCGAGCAGCAGACAATGCGGTCAAGGAAGCCGGTGTTCAAGTTTTTCTGACGGCAACTTCAACAGATGAATTG
GATAAAAAAGTCAGAACAGGCAAATTAAGTCGTCTTAGTTTGCCAAGGCGCTTTCATGGCAACCCACTTATTGTCCCGCA
AAAAGTCTGGTTTAGTAAATTCGATGATACCCTAAAGAAAAATAGACTAGTTCCAAAGTTGAAAAAAGCGATTGAAGAAC
AGAGAAAGTCGTGCTTTCCCTTACTCATTTTTGTCCCAGAAATCTCCAAAGGTCAAGAATTTACCAAGATAATGAAAAAA
ACATTCCCAGAAGAAACAATTGGCTTTGTATCCAGTCAAACAGAAAATCGCCTTGAAATAGTTGAAGGGTTTCGCAAGAG
AGAAATCACAGTCTTAATCTCGACTACTATTCTTGAACGTGGGGTGACCTTCCCATGTGTAGACGTCTTTGTTGTTCAAG
CTAATCATTACCTCTTCACAGCGTCCAGTCTTGTTCAGATTGCAGGCCGGGTTGGCAGGAGTATAGAACGTCCGACTGGT
TTACTCCAGTTTTATCATGAGGGAAGTACAGGAGCCATTGAAAAGGCAATCGCTGAAATTAAACAGATGAACAAGGAGGC
TGGTTATGTCTAA

Domains

Predicted by InterproScan.

Helicase conserved C-terminal domain (Helicase_C)

(294-393)

Type III restriction enzyme, res subunit (ResIII)

(91-235)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A075SHM8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comFA/cflA Streptococcus mitis NCTC 12261

67.053

100

0.672
  comFA/cflA Streptococcus pneumoniae Rx1

66.589

100

0.667
  comFA/cflA Streptococcus pneumoniae D39

66.589

100

0.667
  comFA/cflA Streptococcus pneumoniae R6

66.589

100

0.667
  comFA/cflA Streptococcus pneumoniae TIGR4

66.589

100

0.667
  comFA/cflA Streptococcus mitis SK321

65.893

100

0.66
  comFA Lactococcus lactis subsp. cremoris KW2

53.904

92.326

0.498
  comFA Latilactobacillus sakei subsp. sakei 23K

38.106

100

0.384
  comFA Bacillus subtilis subsp. subtilis str. 168

37.59

96.512

0.363