Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   NPS16_RS05220 Genome accession   NZ_CP101986
Coordinates   1153615..1154922 (-) Length   435 a.a.
NCBI ID   WP_002264510.1    Uniprot ID   -
Organism   Streptococcus mutans strain COCC33-14     
Function   Required for optimal comC expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1148615..1159922
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NPS16_RS05190 (NPS16_05190) - 1149163..1149633 (-) 471 WP_374684426.1 cytidine deaminase -
  NPS16_RS05195 (NPS16_05195) deoC 1149539..1150201 (-) 663 WP_002262220.1 deoxyribose-phosphate aldolase -
  NPS16_RS05200 (NPS16_05200) - 1150220..1151497 (-) 1278 WP_258968806.1 pyrimidine-nucleoside phosphorylase -
  NPS16_RS05205 (NPS16_05205) - 1151606..1152202 (-) 597 WP_019323635.1 class I SAM-dependent methyltransferase -
  NPS16_RS05210 (NPS16_05210) coaA 1152298..1153218 (+) 921 WP_002262217.1 type I pantothenate kinase -
  NPS16_RS05215 (NPS16_05215) rpsT 1153272..1153526 (+) 255 WP_011074586.1 30S ribosomal protein S20 -
  NPS16_RS05220 (NPS16_05220) ciaH 1153615..1154922 (-) 1308 WP_002264510.1 three-component system sensor histidine kinase CiaH Regulator
  NPS16_RS05225 (NPS16_05225) ciaR 1154912..1155586 (-) 675 WP_002264509.1 three-component system response regulator CiaR Regulator
  NPS16_RS05230 (NPS16_05230) ciaX 1155637..1155900 (-) 264 WP_002281780.1 three-component system regulator CiaX -
  NPS16_RS05235 (NPS16_05235) - 1156302..1158851 (-) 2550 WP_082999550.1 M1 family metallopeptidase -
  NPS16_RS05240 (NPS16_05240) phoU 1158892..1159545 (-) 654 WP_002262211.1 phosphate signaling complex protein PhoU -

Sequence

Protein


Download         Length: 435 a.a.        Molecular weight: 49856.29 Da        Isoelectric Point: 9.7262

>NTDB_id=713650 NPS16_RS05220 WP_002264510.1 1153615..1154922(-) (ciaH) [Streptococcus mutans strain COCC33-14]
MLIKLRKQKQDENISFFSHFFAVFTGIFFVMTVIIIQVMHFGIYSSVDNSLKIATENVNDYVNMTLSHNNPITEAENGDA
SFKVKSNGQMAANTDTILYDKKHNVINNVNAFSSLYHIRPKLKDIGDIVEQEAKNIYGQTEKYRTVTVKVNNDFYPQIKF
ATIVINTTQLEEANTRYVTIIISVMIVFWLISVIASVYLAKWSQKPILENYEKQKSFVENASHELRTPLAVLQNRLESLF
RKPEATILDSSESIASSLEEVRNMRMLTANLLNLARRDDGIKPEITEIQPRFFDDTFKNYEMIARENGKKLHITNKVNRQ
IKTDKTLLKQLMTILFDNAVKYTDNDGEIWLDVKTTDRSLIFSVADNGQGISDEDKKKIFDRFYRVDKARTRQKGGFGLG
LSLAKQITDSLKGSIIVKDKKPQGVMFEARLLANK

Nucleotide


Download         Length: 1308 bp        

>NTDB_id=713650 NPS16_RS05220 WP_002264510.1 1153615..1154922(-) (ciaH) [Streptococcus mutans strain COCC33-14]
ATGCTAATTAAATTAAGAAAACAAAAGCAGGATGAGAATATTTCATTTTTCAGTCATTTCTTTGCTGTTTTTACCGGAAT
ATTCTTTGTTATGACAGTTATTATTATTCAGGTTATGCATTTTGGTATCTATTCTTCAGTTGATAATAGTCTAAAAATAG
CAACTGAGAATGTCAATGATTATGTCAATATGACTCTATCGCATAATAATCCTATTACTGAAGCTGAAAATGGAGATGCC
TCTTTTAAAGTAAAATCAAATGGCCAGATGGCTGCTAATACAGATACTATTCTTTATGATAAAAAGCATAACGTCATCAA
TAATGTCAATGCCTTCTCTTCTTTGTATCATATTCGCCCTAAACTAAAAGATATTGGTGATATTGTTGAACAAGAAGCTA
AGAATATTTACGGTCAGACCGAAAAGTATCGGACAGTGACAGTTAAGGTAAATAATGATTTTTACCCACAGATAAAATTT
GCAACAATTGTTATTAATACAACACAGCTTGAAGAGGCTAATACGCGTTATGTTACGATTATTATCAGTGTGATGATTGT
TTTTTGGCTTATATCAGTTATTGCCAGTGTTTATTTAGCGAAGTGGAGTCAAAAACCGATTCTGGAAAATTATGAAAAGC
AAAAATCATTTGTTGAAAATGCCAGTCATGAATTACGTACTCCTTTGGCTGTTTTGCAAAATCGCTTGGAGAGTTTGTTT
CGAAAACCAGAGGCTACTATCTTAGATTCTTCGGAATCTATTGCTTCTAGTTTGGAAGAGGTCAGAAACATGAGAATGCT
GACAGCAAATCTCCTTAATTTAGCCCGTCGGGATGATGGTATCAAACCAGAAATAACAGAAATTCAACCTCGTTTTTTTG
ATGATACTTTTAAAAATTATGAGATGATCGCTCGAGAAAATGGGAAAAAATTGCATATTACCAATAAGGTCAACCGTCAA
ATTAAGACAGATAAGACTTTGCTGAAGCAATTAATGACTATTCTTTTTGATAATGCTGTCAAATATACAGATAACGACGG
GGAAATTTGGCTGGACGTCAAGACAACTGATCGCAGTTTAATTTTTTCAGTTGCGGACAATGGTCAAGGTATTTCAGACG
AGGATAAGAAAAAAATTTTTGATCGTTTTTATCGCGTCGATAAAGCCAGAACACGACAAAAGGGTGGGTTCGGACTTGGT
TTGTCTTTGGCAAAACAAATAACAGACAGCTTAAAAGGCAGCATTATTGTTAAAGATAAAAAACCACAAGGAGTAATGTT
TGAAGCTCGCCTGCTTGCTAATAAATAA

Domains

Predicted by InterproScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(215-280)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(324-431)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus mutans UA159

99.77

100

0.998
  ciaH Streptococcus pneumoniae Rx1

55.632

100

0.556
  ciaH Streptococcus pneumoniae D39

55.632

100

0.556
  ciaH Streptococcus pneumoniae R6

55.632

100

0.556
  ciaH Streptococcus pneumoniae TIGR4

55.632

100

0.556