Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   NOV99_RS03660 Genome accession   NZ_CP101844
Coordinates   730768..732147 (+) Length   459 a.a.
NCBI ID   WP_002935290.1    Uniprot ID   A0A0Z8I1B6
Organism   Streptococcus suis strain 2018WUSS151     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 725768..737147
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NOV99_RS03635 (NOV99_03635) pstB 726300..727058 (+) 759 WP_002937614.1 phosphate ABC transporter ATP-binding protein PstB -
  NOV99_RS03640 (NOV99_03640) phoU 727087..727743 (+) 657 WP_002937611.1 phosphate signaling complex protein PhoU -
  NOV99_RS03645 (NOV99_03645) - 727945..729145 (-) 1201 Protein_691 IS110-like element ISSsu7 family transposase -
  NOV99_RS03650 (NOV99_03650) - 729530..729910 (+) 381 WP_002935294.1 hypothetical protein -
  NOV99_RS03655 (NOV99_03655) ciaR 730104..730775 (+) 672 WP_009909965.1 response regulator transcription factor Regulator
  NOV99_RS03660 (NOV99_03660) ciaH 730768..732147 (+) 1380 WP_002935290.1 cell wall metabolism sensor histidine kinase WalK Regulator
  NOV99_RS03665 (NOV99_03665) - 732471..733700 (+) 1230 WP_002935288.1 transglutaminase domain-containing protein -
  NOV99_RS03670 (NOV99_03670) rpsT 733962..734210 (-) 249 WP_012027069.1 30S ribosomal protein S20 -
  NOV99_RS03675 (NOV99_03675) coaA 734269..735189 (-) 921 WP_002935283.1 type I pantothenate kinase -
  NOV99_RS03680 (NOV99_03680) - 735298..735888 (+) 591 WP_009909951.1 class I SAM-dependent methyltransferase -

Sequence

Protein


Download         Length: 459 a.a.        Molecular weight: 51921.60 Da        Isoelectric Point: 6.8879

>NTDB_id=712309 NOV99_RS03660 WP_002935290.1 730768..732147(+) (ciaH) [Streptococcus suis strain 2018WUSS151]
MPKRFKKLMYTDKFSFFIRYFAVFTLIFGLMTAIIFQLMRSTMYQNSDNTLKRIKKEPALAVGFAIARTYEPNSVFILQD
SPTGEETTSSSSDSTPVPKNQKNTRAGDQLRLGANTHVLLYSKSGEMINPDTFTGLADLSLDKEKLGEIKETTVESSFGM
SEDYRYITIGLATDELGYYSSYDIKYATILVNVSQIKSSIESYESTVAIVMVSAWLISILASIYLSNLSMRPILISYQKQ
KDFVENASHELRTPLAVLQNRLESLFRHPETTILESSESIGSSLEEVRNMRLLTTNLLNLARRDDGLKVDMIDVQPNYFD
EIFANYLMIAEENGKTLTVNNLIHQPIRTDKVLIKQLLTILFDNAMKYTDDDGTIQMAANIKDKLVCFTVIDNGLGISDA
DKKKIFDRFYRVDKARTRQKGGFGLGLSLAQQIIKNLDGEISVRDNQPKGTIFEVRLPK

Nucleotide


Download         Length: 1380 bp        

>NTDB_id=712309 NOV99_RS03660 WP_002935290.1 730768..732147(+) (ciaH) [Streptococcus suis strain 2018WUSS151]
ATGCCTAAGCGATTTAAAAAATTAATGTACACGGATAAATTTTCTTTCTTTATCCGTTATTTTGCAGTATTTACTCTGAT
TTTTGGTTTAATGACAGCCATCATTTTTCAATTAATGCGTTCAACTATGTACCAAAATTCAGATAACACCTTGAAACGCA
TTAAGAAAGAACCAGCGCTGGCTGTTGGTTTTGCAATCGCAAGAACCTATGAGCCCAATTCTGTATTTATCCTTCAAGAT
AGTCCAACTGGTGAAGAAACTACGAGCTCTAGTTCAGATAGCACGCCTGTTCCTAAAAATCAAAAAAATACTAGAGCTGG
AGATCAGCTGAGGTTAGGTGCCAATACTCATGTTTTACTCTATAGTAAAAGTGGAGAGATGATTAATCCAGATACTTTTA
CTGGTTTGGCCGACCTATCATTAGACAAGGAAAAATTGGGTGAAATTAAGGAAACTACGGTTGAATCAAGTTTTGGTATG
TCTGAAGATTATCGCTATATAACGATTGGGCTGGCTACAGATGAACTAGGGTATTATTCGTCCTATGATATAAAATATGC
GACAATTTTGGTGAATGTCAGCCAAATTAAATCTTCCATTGAGAGCTATGAATCGACAGTTGCTATTGTTATGGTATCAG
CTTGGTTGATTTCTATACTAGCAAGTATTTACCTATCGAATCTTAGCATGCGTCCAATCCTAATTAGTTATCAAAAACAA
AAAGACTTCGTTGAAAATGCTAGTCATGAGTTACGCACACCGTTGGCAGTTCTTCAAAATCGCCTGGAAAGTCTATTTCG
TCATCCCGAGACAACTATTTTGGAAAGTAGTGAAAGCATCGGATCTAGTTTAGAAGAAGTTCGAAATATGCGACTATTGA
CAACAAATTTACTTAATTTGGCTCGTCGTGATGATGGCTTAAAAGTCGATATGATCGATGTCCAACCCAACTATTTTGAT
GAAATCTTTGCTAATTACCTTATGATTGCCGAAGAAAATGGAAAAACTCTAACAGTTAATAATTTGATTCATCAGCCAAT
TCGAACAGACAAAGTTTTGATTAAACAGTTGCTCACCATTTTGTTTGACAACGCTATGAAGTATACCGATGATGATGGGA
CAATTCAAATGGCAGCTAATATCAAGGATAAACTAGTTTGTTTTACAGTTATTGACAATGGTTTGGGAATCAGCGATGCC
GATAAAAAGAAAATCTTTGATCGCTTTTACCGAGTTGACAAGGCTAGAACACGTCAAAAAGGTGGATTTGGTTTAGGTTT
ATCTTTAGCTCAACAAATTATTAAGAATTTAGATGGTGAGATTTCTGTGAGAGATAACCAACCGAAAGGAACTATTTTTG
AGGTACGTTTACCCAAATAA

Domains

Predicted by InterproScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(240-306)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(350-458)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0Z8I1B6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

49.127

99.782

0.49
  ciaH Streptococcus pneumoniae D39

49.127

99.782

0.49
  ciaH Streptococcus pneumoniae R6

49.127

99.782

0.49
  ciaH Streptococcus pneumoniae TIGR4

49.127

99.782

0.49
  ciaH Streptococcus mutans UA159

48.791

99.129

0.484