Detailed information    

insolico Bioinformatically predicted

Overview

Name   pilC   Type   Machinery gene
Locus tag   K6J56_RS03625 Genome accession   NZ_AP018768
Coordinates   714204..715424 (+) Length   406 a.a.
NCBI ID   WP_011271971.1    Uniprot ID   Q4QNP6
Organism   Haemophilus influenzae strain CHBN-II-5 isolate 13H40     
Function   type IV pilus biogenesis and function (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 709204..720424
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  K6J56_RS03605 (CHBNII5_06860) corC 710166..711065 (-) 900 WP_044364861.1 CNNM family magnesium/cobalt transport protein CorC -
  K6J56_RS03610 (CHBNII5_06870) ampD 711698..712252 (-) 555 WP_044364862.1 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD -
  K6J56_RS03615 (CHBNII5_06880) pilA 712367..712816 (+) 450 WP_044364865.1 prepilin-type N-terminal cleavage/methylation domain-containing protein Machinery gene
  K6J56_RS03620 (CHBNII5_06890) pilB 712813..714207 (+) 1395 WP_044364868.1 GspE/PulE family protein Machinery gene
  K6J56_RS03625 (CHBNII5_06900) pilC 714204..715424 (+) 1221 WP_011271971.1 type II secretion system F family protein Machinery gene
  K6J56_RS03630 (CHBNII5_06910) pilD 715421..716113 (+) 693 WP_038440789.1 A24 family peptidase Machinery gene
  K6J56_RS03635 (CHBNII5_06920) rho 716167..717429 (-) 1263 WP_005629550.1 transcription termination factor Rho -
  K6J56_RS03640 (CHBNII5_06930) metJ 717677..717994 (+) 318 WP_005631186.1 met regulon transcriptional regulator MetJ -
  K6J56_RS03645 (CHBNII5_06940) cueR 718008..718394 (-) 387 WP_005663006.1 Cu(I)-responsive transcriptional regulator -
  K6J56_RS03650 (CHBNII5_06950) - 718471..718677 (+) 207 WP_012054944.1 heavy-metal-associated domain-containing protein -
  K6J56_RS03655 (CHBNII5_06960) - 718763..718969 (+) 207 WP_005648955.1 heavy-metal-associated domain-containing protein -
  K6J56_RS03660 (CHBNII5_06970) - 719055..719261 (+) 207 WP_012054944.1 heavy-metal-associated domain-containing protein -
  K6J56_RS03665 (CHBNII5_06980) - 719347..719553 (+) 207 WP_005631184.1 heavy-metal-associated domain-containing protein -

Sequence

Protein


Download         Length: 406 a.a.        Molecular weight: 46259.57 Da        Isoelectric Point: 10.0444

>NTDB_id=70868 K6J56_RS03625 WP_011271971.1 714204..715424(+) (pilC) [Haemophilus influenzae strain CHBN-II-5 isolate 13H40]
MTKKLFYYQGSNALNQKQKGSIIADTKQQAHFQLISRGLTHIKLQQNWQFGAKPKNSEISELLNQLATLLQSVIPLKNSL
QILQQNCTQIMLNKWLERLLQSIESGLAFSQAIEQQGKYLTQQEIQLIQVGEMTGKLAVVCKKIATHRSQSLALQRKLQK
IMLYPSMVLGISLLLTLALLLFIAPQFAEMYSGNNAELPTITAILLSISNFLKQNIGILLFFVLSFFLFYYFYLKRQTWF
HQKKNQLISITPIFGTIQKLSRLVNFSQSLQIMLQAGVPLNQALDSFLPRTQTWQTKKTLVNDMVLDKEVRSILQWVSQG
YAFSNSVSSDLFPMEAQQMLQIGEQSGKLALMLEHIADNYQEKLNHQIDLLSQMLEPLMMVIIGSLIGIIMMGMYLPIFN
MGSVIQ

Nucleotide


Download         Length: 1221 bp        

>NTDB_id=70868 K6J56_RS03625 WP_011271971.1 714204..715424(+) (pilC) [Haemophilus influenzae strain CHBN-II-5 isolate 13H40]
ATGACTAAAAAACTCTTTTATTATCAAGGTAGTAACGCATTAAATCAGAAACAAAAAGGCTCAATTATTGCGGATACGAA
ACAACAAGCGCACTTTCAGTTAATAAGCCGCGGGCTTACTCACATCAAATTACAACAAAACTGGCAATTTGGGGCAAAAC
CCAAAAATTCAGAAATCAGTGAATTACTCAATCAATTAGCGACATTGCTACAGTCCGTAATTCCGTTAAAAAACAGCCTA
CAAATTTTGCAACAAAATTGTACTCAAATTATGCTCAACAAATGGCTTGAACGACTGCTTCAATCCATTGAATCTGGCTT
AGCATTCTCACAAGCCATTGAACAACAAGGAAAATATCTCACACAACAAGAAATTCAACTGATTCAAGTGGGAGAAATGA
CAGGAAAACTTGCCGTAGTTTGTAAAAAAATAGCCACGCACCGTAGTCAATCTTTGGCTTTACAACGCAAATTACAGAAA
ATTATGTTATATCCCTCAATGGTATTGGGAATTTCTCTATTATTGACACTCGCATTACTGCTTTTTATCGCGCCTCAATT
TGCTGAAATGTACAGTGGCAATAATGCGGAGTTACCAACAATAACCGCAATATTGCTCTCAATATCTAATTTCCTTAAGC
AAAATATTGGCATTTTGCTATTTTTCGTTTTGAGTTTTTTTCTATTTTATTATTTCTATCTAAAACGCCAGACTTGGTTT
CATCAAAAGAAAAATCAACTTATTTCTATCACGCCTATTTTTGGCACAATTCAAAAGCTTTCACGTTTAGTGAACTTTAG
TCAAAGTTTACAAATTATGTTGCAGGCCGGCGTACCGCTTAATCAGGCACTAGACAGTTTTCTTCCTCGCACACAAACTT
GGCAAACCAAGAAAACGCTTGTAAACGATATGGTATTAGATAAAGAAGTGCGGTCAATTTTGCAATGGGTTTCTCAAGGC
TATGCGTTTTCTAATAGCGTAAGTAGCGATCTTTTCCCGATGGAAGCACAACAAATGCTACAAATTGGCGAACAAAGCGG
AAAACTCGCTTTGATGCTAGAGCATATCGCAGATAATTACCAAGAAAAACTTAATCATCAAATTGACTTACTCTCACAAA
TGCTAGAACCATTAATGATGGTAATCATCGGCAGTCTGATTGGGATTATTATGATGGGAATGTATTTACCTATCTTTAAT
ATGGGATCAGTTATTCAATGA

Domains

Predicted by InterproScan.

Type II secretion system (T2SS), protein F (T2SSF)

(63-185)

Type II secretion system (T2SS), protein F (T2SSF)

(266-397)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q4QNP6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pilC Haemophilus influenzae 86-028NP

100

100

1
  pilC Haemophilus influenzae Rd KW20

97.783

100

0.978
  pilC Glaesserella parasuis strain SC1401

38.155

98.768

0.377

Multiple sequence alignment