Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   H7674_RS02585 Genome accession   NZ_AP023388
Coordinates   509796..510437 (+) Length   213 a.a.
NCBI ID   WP_002983671.1    Uniprot ID   A0A0H2UW05
Organism   Streptococcus pyogenes strain NIH35     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 504796..515437
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H7674_RS02565 (SPNIH35_04570) - 505352..506092 (+) 741 WP_002983660.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  H7674_RS02570 (SPNIH35_04580) pknB 506089..507987 (+) 1899 WP_002994648.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  H7674_RS02575 (SPNIH35_04590) liaF 508110..508802 (+) 693 WP_011054833.1 cell wall-active antibiotics response protein LiaF -
  H7674_RS02580 (SPNIH35_04600) - 508799..509803 (+) 1005 WP_002991890.1 sensor histidine kinase -
  H7674_RS02585 (SPNIH35_04610) vraR 509796..510437 (+) 642 WP_002983671.1 response regulator transcription factor Regulator
  H7674_RS02590 (SPNIH35_04620) - 510474..511874 (+) 1401 WP_021340868.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  H7674_RS02595 (SPNIH35_04630) - 511874..512251 (+) 378 WP_002991882.1 S1 RNA-binding domain-containing protein -
  H7674_RS02600 (SPNIH35_04640) cysK 512269..513210 (-) 942 WP_011285046.1 cysteine synthase A -
  H7674_RS02605 (SPNIH35_04650) - 513338..513970 (-) 633 WP_002988970.1 YigZ family protein -
  H7674_RS02610 (SPNIH35_04660) comFA/cflA 514026..515351 (+) 1326 WP_011285044.1 DEAD/DEAH box helicase Machinery gene

Sequence

Protein


Download         Length: 213 a.a.        Molecular weight: 23751.43 Da        Isoelectric Point: 5.1641

>NTDB_id=70359 H7674_RS02585 WP_002983671.1 509796..510437(+) (vraR) [Streptococcus pyogenes strain NIH35]
MSKIKVILVDDHEMVRMGLKSFLNLQADIDVVGEASNGREGVDLALALKPDVLVMDLVMPELGGVEATLEVLKKWKEAKV
LVLTSYLDNEKIYPVIDAGAKGYMLKTSSAAEILNAIRKVSKGELAIETEVDKKIKAHDQHPDLHEELTAREYDILHLLA
KGYDNQTIADELFISLKTVKTHVSNILAKLEVDDRTQAVVYAFRHHLVPQDDN

Nucleotide


Download         Length: 642 bp        

>NTDB_id=70359 H7674_RS02585 WP_002983671.1 509796..510437(+) (vraR) [Streptococcus pyogenes strain NIH35]
ATGAGTAAGATAAAAGTGATATTGGTCGATGATCATGAAATGGTCCGCATGGGACTCAAGAGTTTTTTGAATTTACAAGC
TGATATTGATGTCGTTGGTGAGGCCTCTAATGGACGTGAAGGGGTTGATTTGGCATTGGCTTTGAAGCCAGATGTTTTGG
TTATGGATCTAGTGATGCCAGAGTTAGGCGGTGTTGAGGCAACTTTAGAAGTTCTAAAAAAATGGAAAGAGGCTAAGGTA
CTTGTGTTAACTTCCTATCTAGATAATGAAAAGATATACCCTGTCATTGATGCAGGAGCGAAGGGTTATATGTTAAAAAC
ATCGAGTGCGGCTGAAATTTTAAATGCCATTCGCAAGGTTTCAAAGGGAGAGTTAGCTATTGAAACAGAAGTTGACAAAA
AAATTAAGGCGCATGATCAACACCCTGACTTGCATGAGGAACTAACAGCGCGTGAGTATGATATTTTACACCTTTTAGCT
AAAGGGTATGATAATCAGACCATCGCTGATGAACTCTTTATTTCCTTAAAAACCGTCAAAACACATGTGTCCAATATTCT
AGCCAAGTTAGAAGTTGATGACCGAACCCAAGCGGTTGTCTATGCTTTTCGACATCATTTAGTCCCCCAAGACGATAATT
AA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(6-118)

Bacterial regulatory proteins, luxR family (GerE)

(148-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0H2UW05

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.913

96.714

0.512
  degU Bacillus subtilis subsp. subtilis str. 168

36.283

100

0.385