Detailed information NTG0697384

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: LC189_RS00445
• Genome accession: NZ_CP098727
• Coordinates: 82248..83291 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain SauR3
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 77248..88291

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LC189_RS00415 (LC189_000415)	-	77733..77843 (+)	111	WP_001790257.1	hypothetical protein	-
LC189_RS00420 (LC189_000420)	-	77872..78285 (+)	414	WP_001837637.1	hypothetical protein	-
LC189_RS00425 (LC189_000425)	-	78716..79702 (-)	987	WP_000999718.1	aromatic acid exporter family protein	-
LC189_RS00430 (LC189_000430)	map	80174..80932 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
LC189_RS00435 (LC189_000435)	-	81149..81535 (+)	387	WP_001110179.1	hypothetical protein	-
LC189_RS00440 (LC189_000440)	liaF	81550..82251 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
LC189_RS00445 (LC189_000445)	vraS	82248..83291 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
LC189_RS00450 (LC189_000450)	vraR	83281..83910 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
LC189_RS00455 (LC189_000455)	-	84022..85239 (-)	1218	WP_000037078.1	YihY/virulence factor BrkB family protein	-
LC189_RS00460 (LC189_000460)	-	85517..85792 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
LC189_RS00465 (LC189_000465)	-	85799..86263 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
LC189_RS00470 (LC189_000470)	-	86410..86610 (+)	201	WP_000180460.1	DUF1128 family protein	-
LC189_RS00475 (LC189_000475)	-	86613..87869 (+)	1257	WP_075583716.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=697384 LC189_RS00445 WP_001017131.1 82248..83291(+) (vraS) [Staphylococcus aureus strain SauR3]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=697384 LC189_RS00445 WP_001017131.1 82248..83291(+) (vraS) [Staphylococcus aureus strain SauR3]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1