Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   SR187_RS04045 Genome accession   NZ_AP018400
Coordinates   832591..833961 (+) Length   456 a.a.
NCBI ID   WP_120171597.1    Uniprot ID   A0A2Z5TM55
Organism   Streptococcus ruminantium strain GUT-187     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 827591..838961
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SR187_RS04020 (SR187_4115) pstA 828404..829291 (+) 888 WP_024531693.1 phosphate ABC transporter permease PstA -
  SR187_RS04025 (SR187_4120) pstB 829317..830120 (+) 804 WP_024531694.1 phosphate ABC transporter ATP-binding protein PstB -
  SR187_RS04030 (SR187_4125) pstB 830132..830890 (+) 759 WP_120171595.1 phosphate ABC transporter ATP-binding protein PstB -
  SR187_RS04035 (SR187_4130) phoU 830920..831576 (+) 657 WP_024531696.1 phosphate signaling complex protein PhoU -
  SR187_RS04040 (SR187_4135) ciaR 831924..832598 (+) 675 WP_120171596.1 response regulator transcription factor Regulator
  SR187_RS04045 (SR187_4140) ciaH 832591..833961 (+) 1371 WP_120171597.1 cell wall metabolism sensor histidine kinase WalK Regulator
  SR187_RS04050 (SR187_4145) - 834132..834896 (+) 765 WP_227985742.1 hypothetical protein -
  SR187_RS04055 (SR187_4150) - 834896..836083 (+) 1188 WP_120171598.1 DUF1266 domain-containing protein -
  SR187_RS04060 (SR187_4160) rpsT 836372..836620 (-) 249 WP_075098301.1 30S ribosomal protein S20 -
  SR187_RS04065 (SR187_4165) coaA 836679..837599 (-) 921 WP_024531701.1 type I pantothenate kinase -
  SR187_RS04070 (SR187_4170) - 837712..838302 (+) 591 WP_120171599.1 class I SAM-dependent methyltransferase -

Sequence

Protein


Download         Length: 456 a.a.        Molecular weight: 51950.70 Da        Isoelectric Point: 6.9789

>NTDB_id=69451 SR187_RS04045 WP_120171597.1 832591..833961(+) (ciaH) [Streptococcus ruminantium strain GUT-187]
MTKRFRKLVYTDKFSFFIRYFAVFTLIFGLMTAIIFQLMRSTMYENSDDTLHRIKEEPAMAVGLAVARAYQPNSELTLQD
NSNRNTTASILDDTMTPQSGNGEQLRLGVNTHVLLYNKNGEIINPDKFTGLSRLTLDKENLDEIRETTVKSSFGLNENYR
YVTIKLVVEELGHYAVYDIKYATILVNVSQIKSSIEKYEATVAVVMVSAWLISILASIYLSNLSMRPILTSYQKQKDFVE
NASHELRTPLAVLQNRLEGLFRHPETTILESSESIGSSLEEVRNMRLLTTNLLNLARRDDGFKLDMVEVPPTYFDEIFDN
YIIIAEENGKKVTVNNLISQSIRTDKVLIKQLLTILFDNAMKYTDDDCDIQITASIKDKLVCFTIADNGLGITDNDKKKI
FDRFYRVDKARTRQKGGFGLGLSLAQQIIKALNGEIFVRDNQPKGTVFEVQLPIKK

Nucleotide


Download         Length: 1371 bp        

>NTDB_id=69451 SR187_RS04045 WP_120171597.1 832591..833961(+) (ciaH) [Streptococcus ruminantium strain GUT-187]
ATGACTAAGCGATTTAGAAAGCTAGTTTACACGGATAAATTTTCTTTCTTTATCCGCTATTTTGCAGTCTTTACTCTGAT
TTTTGGTCTGATGACAGCTATCATCTTTCAATTGATGCGTTCAACCATGTATGAAAATTCGGATGACACGCTACATCGAA
TCAAAGAAGAACCTGCAATGGCAGTTGGACTGGCAGTGGCGAGAGCCTATCAACCGAATTCAGAACTCACTCTCCAAGAC
AATTCAAATAGGAATACGACGGCTTCCATTTTGGATGATACGATGACGCCCCAAAGCGGAAATGGGGAACAATTGAGGTT
GGGAGTGAATACTCACGTACTGCTGTATAACAAGAATGGTGAAATCATTAACCCTGATAAATTCACCGGCTTATCAAGGT
TGACCTTAGACAAGGAAAATTTAGATGAAATTAGGGAAACGACCGTTAAATCTTCTTTTGGACTGAATGAAAATTATCGT
TATGTAACGATTAAACTGGTAGTCGAGGAACTCGGTCATTATGCGGTTTACGATATAAAGTATGCAACTATCCTAGTGAA
TGTTAGCCAAATTAAATCATCTATTGAGAAGTATGAAGCAACAGTTGCTGTTGTAATGGTTTCTGCTTGGTTGATTTCTA
TCTTGGCAAGTATTTACTTGTCCAATCTTAGTATGCGTCCTATTTTGACTAGCTATCAGAAACAAAAGGATTTTGTGGAA
AATGCCAGTCATGAGCTACGTACACCATTAGCTGTTTTACAGAACCGCTTGGAAGGGTTGTTCCGTCATCCTGAAACGAC
CATTTTGGAAAGTAGCGAAAGTATCGGATCTAGTTTGGAGGAGGTCCGCAATATGCGGTTACTGACGACCAATTTGCTCA
ATCTCGCACGCCGGGATGATGGTTTTAAACTAGATATGGTAGAAGTACCTCCTACCTATTTTGATGAAATATTTGATAAC
TATATTATAATTGCTGAAGAAAACGGCAAGAAGGTGACTGTCAACAATTTAATTAGCCAGTCTATTCGAACGGACAAAGT
TTTAATTAAGCAATTGCTGACCATCTTATTTGATAATGCAATGAAATACACCGATGATGATTGCGATATTCAAATTACAG
CCAGTATAAAAGATAAATTAGTCTGCTTTACCATTGCGGATAATGGCTTAGGAATTACCGACAACGACAAAAAGAAAATA
TTTGATCGTTTCTATCGGGTTGATAAGGCTAGAACACGTCAAAAAGGTGGATTCGGTCTAGGCTTATCTTTGGCGCAGCA
GATTATCAAGGCTCTGAATGGAGAAATTTTCGTTAGGGATAATCAGCCTAAAGGGACTGTTTTTGAGGTGCAACTTCCAA
TCAAAAAATAA

Domains

Predicted by InterproScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(235-301)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(345-454)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2Z5TM55

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

49.781

100

0.498
  ciaH Streptococcus pneumoniae D39

49.781

100

0.498
  ciaH Streptococcus pneumoniae R6

49.781

100

0.498
  ciaH Streptococcus pneumoniae TIGR4

49.781

100

0.498
  ciaH Streptococcus mutans UA159

48.565

99.342

0.482

Multiple sequence alignment