Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   M9H69_RS06240 Genome accession   NZ_CP097843
Coordinates   1210641..1211978 (-) Length   445 a.a.
NCBI ID   WP_084872931.1    Uniprot ID   A0AAX0N3S6
Organism   Streptococcus oralis strain HP01     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1205641..1216978
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  M9H69_RS06215 (M9H69_06215) rpiA 1206309..1206992 (-) 684 WP_250315098.1 ribose-5-phosphate isomerase RpiA -
  M9H69_RS06220 (M9H69_06220) - 1207098..1208027 (-) 930 WP_250315100.1 peptidase U32 family protein -
  M9H69_RS06225 (M9H69_06225) - 1208158..1208838 (-) 681 WP_250315102.1 ABC transporter ATP-binding protein -
  M9H69_RS06230 (M9H69_06230) - 1208852..1209907 (-) 1056 WP_250315103.1 ABC transporter permease -
  M9H69_RS06235 (M9H69_06235) - 1210293..1210577 (+) 285 WP_250315104.1 DUF3270 domain-containing protein -
  M9H69_RS06240 (M9H69_06240) ciaH 1210641..1211978 (-) 1338 WP_084872931.1 HAMP domain-containing sensor histidine kinase Regulator
  M9H69_RS06245 (M9H69_06245) ciaR 1211968..1212642 (-) 675 WP_000590630.1 two-component system response regulator CiaR Regulator
  M9H69_RS06250 (M9H69_06250) - 1212753..1215299 (-) 2547 WP_250315105.1 M1 family metallopeptidase -
  M9H69_RS06255 (M9H69_06255) - 1215421..1215861 (-) 441 WP_084872927.1 ASCH domain-containing protein -
  M9H69_RS06260 (M9H69_06260) - 1215858..1216706 (-) 849 WP_250315106.1 putative PEP-binding protein -

Sequence

Protein


Download         Length: 445 a.a.        Molecular weight: 50790.56 Da        Isoelectric Point: 9.5838

>NTDB_id=692931 M9H69_RS06240 WP_084872931.1 1210641..1211978(-) (ciaH) [Streptococcus oralis strain HP01]
MFNKLKKTWYADDFSYFIRNFGVFTLIFSAMTLIILQVMHSSLYTSVDEKLQALSSSPQAVIQLALNRATEEVKDIQPAT
ADASKAEIKPNVSSNTEVLLFDKDFNQLLLGNRFLGLDKIKLDKKELNHIRQIQVVNSYGLEETYRMILMETNSSTVSSN
VKYAAILINTSQLEQISQNHEHLIVVVMASFWLLSLIASVYLARVSVKPLLESMQKQKSFVENASHELRTPLAVLQNRLE
TLFRKPEATIMESSESIASSLEEVRNMRFLTTNLLNLARRDDGIKPEIAEVSPQFFKTTFANYELIASENDRIFEYENRI
YRSFMTDQLLLKQLMTILFDNAIKYTEEDGKIEFVVHATDRHLYLSVTDNGIGISAADKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDALRGTITVKDNKPRGTIFEVKIAIQSPPKRKNK

Nucleotide


Download         Length: 1338 bp        

>NTDB_id=692931 M9H69_RS06240 WP_084872931.1 1210641..1211978(-) (ciaH) [Streptococcus oralis strain HP01]
ATGTTCAATAAACTAAAAAAAACATGGTATGCGGATGATTTCAGTTATTTTATTCGAAACTTTGGAGTGTTCACCCTGAT
CTTCTCTGCTATGACCTTGATTATCCTCCAGGTCATGCACTCGAGTCTCTACACTTCTGTAGATGAAAAACTCCAAGCTC
TTAGTAGTAGTCCCCAAGCGGTTATCCAGTTAGCCCTGAATCGGGCAACTGAGGAAGTCAAGGATATTCAACCAGCAACA
GCGGATGCCAGCAAGGCTGAAATCAAACCCAATGTCAGCTCCAATACGGAAGTCTTGCTCTTTGACAAGGATTTTAACCA
ACTCTTACTGGGCAATCGTTTTTTAGGTTTGGATAAGATCAAGCTGGATAAGAAAGAGTTGAATCACATTCGTCAAATCC
AAGTTGTCAATAGCTACGGTCTGGAAGAAACCTACCGGATGATCTTGATGGAAACCAATTCATCCACTGTTTCAAGTAAT
GTCAAATATGCGGCAATCTTGATCAACACTAGTCAGCTTGAGCAGATTAGCCAAAACCATGAGCATTTAATCGTAGTGGT
CATGGCCAGTTTCTGGCTCCTATCTTTAATTGCCAGTGTTTATCTGGCACGTGTCAGTGTCAAACCTCTGCTGGAAAGTA
TGCAAAAGCAGAAGTCCTTTGTCGAAAATGCCAGCCACGAACTGAGAACGCCTTTGGCCGTTTTACAAAATCGTTTAGAG
ACTCTCTTTCGAAAACCAGAGGCAACGATTATGGAATCCAGCGAAAGTATCGCTTCGAGTCTTGAAGAAGTTCGCAACAT
GCGTTTCCTCACGACCAATCTTCTCAACCTTGCACGTCGAGATGATGGAATCAAACCAGAAATAGCAGAAGTATCACCAC
AGTTTTTTAAGACTACCTTTGCCAACTATGAGTTGATTGCTTCTGAAAATGATCGTATTTTTGAGTATGAAAATCGGATT
TATCGTTCTTTTATGACCGATCAGTTGCTTCTAAAACAGCTCATGACCATCTTATTTGATAATGCCATTAAGTATACTGA
AGAAGATGGGAAAATTGAGTTTGTGGTCCATGCTACGGATCGCCACCTCTATCTATCCGTAACGGATAACGGAATTGGGA
TTTCAGCTGCCGATAAGAAGAAAATCTTTGACCGCTTTTATCGTGTAGACAAGGCGAGAACTCGTCAGAAAGGCGGTTTT
GGTCTAGGTTTGTCTTTGGCCAAGCAAATTGTTGATGCCTTACGAGGAACGATTACCGTTAAAGATAACAAGCCTAGAGG
AACAATTTTTGAAGTTAAGATTGCTATTCAATCTCCTCCCAAACGTAAGAATAAATAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(327-434)

His Kinase A (phospho-acceptor) domain (HisKA)

(218-283)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

83.747

99.551

0.834
  ciaH Streptococcus pneumoniae D39

83.747

99.551

0.834
  ciaH Streptococcus pneumoniae R6

83.747

99.551

0.834
  ciaH Streptococcus pneumoniae TIGR4

83.747

99.551

0.834
  ciaH Streptococcus mutans UA159

55.149

98.202

0.542