Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   JP49775_RS09720 Genome accession   NZ_AP017922
Coordinates   1940912..1941541 (-) Length   209 a.a.
NCBI ID   WP_000153535.1    Uniprot ID   W8TS97
Organism   Staphylococcus aureus strain JP02758     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1935912..1946541
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  JP49775_RS09690 (JP02758_1799) - 1936332..1936862 (-) 531 WP_031898303.1 acyl-CoA thioesterase -
  JP49775_RS09695 (JP02758_1800) - 1936952..1938208 (-) 1257 WP_072435092.1 aminopeptidase -
  JP49775_RS09700 (JP02758_1801) - 1938211..1938411 (-) 201 WP_072435098.1 DUF1128 family protein -
  JP49775_RS09705 (JP02758_1802) - 1938558..1939022 (+) 465 WP_000228666.1 low molecular weight protein-tyrosine-phosphatase -
  JP49775_RS09710 (JP02758_1803) - 1939029..1939304 (+) 276 WP_000428172.1 YtxH domain-containing protein -
  JP49775_RS09715 (JP02758_1804) - 1939582..1940799 (+) 1218 WP_029550140.1 YihY/virulence factor BrkB family protein -
  JP49775_RS09720 (JP02758_1805) vraR 1940912..1941541 (-) 630 WP_000153535.1 two-component system response regulator VraR Regulator
  JP49775_RS09725 (JP02758_1806) vraS 1941531..1942574 (-) 1044 WP_001017131.1 sensor histidine kinase Regulator
  JP49775_RS09730 (JP02758_1807) liaF 1942571..1943272 (-) 702 WP_029550141.1 cell wall-active antibiotics response protein LiaF -
  JP49775_RS09735 (JP02758_1808) - 1943287..1943673 (-) 387 WP_029550142.1 hypothetical protein -
  JP49775_RS09740 (JP02758_1809) map 1943890..1944648 (-) 759 WP_000636142.1 type I methionyl aminopeptidase -
  JP49775_RS09745 (JP02758_1811) - 1945292..1946278 (+) 987 WP_029550144.1 FUSC family protein -

Sequence

Protein


Download         Length: 209 a.a.        Molecular weight: 23559.32 Da        Isoelectric Point: 5.3935

>NTDB_id=68507 JP49775_RS09720 WP_000153535.1 1940912..1941541(-) (vraR) [Staphylococcus aureus strain JP02758]
MTIKVLFVDDHEMVRIGISSYLSTQSDIEVVGEGASGKEAIAKAHELKPDLILMDLLMEDMDGVEATTQIKKDLPQIKVL
MLTSFIEDKEVYRALDAGVDSYILKTTSAKDIADAVRKTSRGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIA
KGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ

Nucleotide


Download         Length: 630 bp        

>NTDB_id=68507 JP49775_RS09720 WP_000153535.1 1940912..1941541(-) (vraR) [Staphylococcus aureus strain JP02758]
ATGACGATTAAAGTATTGTTTGTGGATGATCATGAAATGGTACGTATAGGAATTTCAAGTTATCTATCAACGCAAAGTGA
TATTGAAGTAGTTGGTGAAGGCGCTTCTGGTAAAGAAGCAATTGCCAAAGCCCATGAGTTGAAGCCAGATTTAATATTAA
TGGATTTACTTATGGAAGACATGGATGGAGTAGAAGCGACGACTCAGATTAAAAAAGATTTACCGCAAATTAAAGTATTA
ATGTTAACTAGTTTTATTGAAGATAAAGAGGTATATCGTGCATTAGATGCAGGTGTCGATAGTTACATTTTAAAAACAAC
AAGTGCAAAAGATATCGCCGATGCAGTTCGTAAAACTTCTAGAGGAGAATCTGTTTTTGAACCGGAAGTTTTAGTGAAAA
TGCGTAACCGTATGAAAAAGCGCGCAGAGTTATATGAAATGCTTACAGAACGAGAAATGGAAATATTATTATTGATTGCG
AAAGGTTACTCAAATCAAGAAATTGCTAGTGCATCGCATATTACTATTAAAACGGTTAAGACACATGTGAGTAACATTTT
AAGTAAGTTAGAAGTGCAAGATAGAACACAAGCTGTTATCTATGCATTCCAACATAATTTAATTCAATAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-116)

Bacterial regulatory proteins, luxR family (GerE)

(147-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB W8TS97

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

100

100

1
  degU Bacillus subtilis subsp. subtilis str. 168

34.821

100

0.373

Multiple sequence alignment