Detailed information NTG0068508

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: JP49775_RS09725
• Genome accession: NZ_AP017922
• Coordinates: 1941531..1942574 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain JP02758
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1936531..1947574

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
JP49775_RS09695 (JP02758_1800)	-	1936952..1938208 (-)	1257	WP_072435092.1	aminopeptidase	-
JP49775_RS09700 (JP02758_1801)	-	1938211..1938411 (-)	201	WP_072435098.1	DUF1128 family protein	-
JP49775_RS09705 (JP02758_1802)	-	1938558..1939022 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
JP49775_RS09710 (JP02758_1803)	-	1939029..1939304 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
JP49775_RS09715 (JP02758_1804)	-	1939582..1940799 (+)	1218	WP_029550140.1	YihY/virulence factor BrkB family protein	-
JP49775_RS09720 (JP02758_1805)	vraR	1940912..1941541 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
JP49775_RS09725 (JP02758_1806)	vraS	1941531..1942574 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
JP49775_RS09730 (JP02758_1807)	liaF	1942571..1943272 (-)	702	WP_029550141.1	cell wall-active antibiotics response protein LiaF	-
JP49775_RS09735 (JP02758_1808)	-	1943287..1943673 (-)	387	WP_029550142.1	hypothetical protein	-
JP49775_RS09740 (JP02758_1809)	map	1943890..1944648 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
JP49775_RS09745 (JP02758_1811)	-	1945292..1946278 (+)	987	WP_029550144.1	FUSC family protein	-
JP49775_RS09750 (JP02758_1812)	-	1946467..1946880 (-)	414	WP_025174370.1	hypothetical protein	-
JP49775_RS09755	-	1946909..1947019 (-)	111	WP_014937049.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=68508 JP49775_RS09725 WP_001017131.1 1941531..1942574(-) (vraS) [Staphylococcus aureus strain JP02758]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=68508 JP49775_RS09725 WP_001017131.1 1941531..1942574(-) (vraS) [Staphylococcus aureus strain JP02758]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1