Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   MZK36_RS06570 Genome accession   NZ_CP096809
Coordinates   1309501..1310826 (-) Length   441 a.a.
NCBI ID   WP_269903013.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain SP007     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1304501..1315826
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MZK36_RS06555 (MZK36_06505) - 1305448..1307898 (-) 2451 WP_000848713.1 bifunctional DnaQ family exonuclease/ATP-dependent helicase -
  MZK36_RS06560 (MZK36_06510) - 1308098..1309027 (-) 930 WP_000411851.1 peptidase U32 family protein -
  MZK36_RS06565 (MZK36_06515) - 1309167..1309454 (+) 288 WP_001145226.1 DUF3270 domain-containing protein -
  MZK36_RS06570 (MZK36_06520) ciaH 1309501..1310826 (-) 1326 WP_269903013.1 two-component system sensor histidine kinase CiaH Regulator
  MZK36_RS06575 (MZK36_06525) ciaR 1310816..1311490 (-) 675 WP_000590640.1 two-component system response regulator CiaR Regulator
  MZK36_RS06580 (MZK36_06530) - 1311599..1314145 (-) 2547 WP_001149107.1 M1 family metallopeptidase -
  MZK36_RS06585 (MZK36_06535) - 1314268..1314708 (-) 441 WP_000188827.1 ASCH domain-containing protein -
  MZK36_RS06590 (MZK36_06540) - 1314683..1315552 (-) 870 WP_001245817.1 putative PEP-binding protein -

Sequence

Protein


Download         Length: 441 a.a.        Molecular weight: 50287.88 Da        Isoelectric Point: 7.0816

>NTDB_id=684216 MZK36_RS06570 WP_269903013.1 1309501..1310826(-) (ciaH) [Streptococcus pneumoniae strain SP007]
MFSKLKKTWYADDFSYFIRNFGVFTLIFSTMTLIILQVMHSSLYTSVDDKLHGLSENPQAVIQLAINRATEEIKDLENAR
ADASKVEIKPNVSSNTEVILFDKDFTQLLSGNRFLGLDKIKLEKKELGHIYQIQVFNSYGQEEIYRVILMETNISSVSTN
IKYAAVLINTSQLEQASQKHEQLIVVVMASFWILSLLASLYLARVSVRPLLESMQKQQSFVENASHELRTPLAVLQNRLE
TLFRKPEATIMDVSESIASSLEEVRNMRFLTTSLLNLARRDDGIKPELAEVPTSFFNTTFTNYEMIASENNRVFRFENRI
HRTIVTDQLLLKQLMTILFDNAVKYTEEDGEIDFLISATDRNLYLLVSDNGIGISTEDKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDALKGTVTVKDNKPKGTIFEVKIAIQTPTI

Nucleotide


Download         Length: 1326 bp        

>NTDB_id=684216 MZK36_RS06570 WP_269903013.1 1309501..1310826(-) (ciaH) [Streptococcus pneumoniae strain SP007]
ATGTTCAGTAAACTTAAAAAAACATGGTATGCGGATGACTTTAGTTATTTTATCCGCAACTTCGGTGTCTTCACCCTGAT
TTTTTCTACAATGACTCTGATTATTTTACAAGTCATGCATTCGAGTCTTTATACTTCGGTGGACGATAAGCTTCATGGAC
TGAGTGAAAATCCTCAAGCAGTTATTCAGCTGGCTATAAATAGGGCAACAGAAGAGATTAAAGATTTAGAAAATGCTAGG
GCGGACGCTAGTAAAGTAGAAATAAAACCTAATGTCAGTTCCAATACGGAAGTCATTCTCTTTGATAAAGACTTTACTCA
ACTTCTTTCTGGAAATCGATTTTTGGGCTTGGATAAGATTAAGTTAGAAAAGAAAGAACTAGGACATATCTACCAGATTC
AGGTTTTTAATAGCTATGGGCAGGAAGAAATCTATCGTGTGATTTTGATGGAGACCAATATTAGTTCGGTTTCAACCAAT
ATCAAGTATGCTGCTGTCTTGATTAATACCAGTCAGTTGGAGCAGGCTAGTCAAAAGCATGAGCAATTGATTGTGGTCGT
GATGGCTAGTTTCTGGATTTTGTCTTTACTTGCCAGTCTCTATCTAGCTAGGGTCAGTGTTAGGCCCCTGCTTGAGAGTA
TGCAGAAGCAACAGTCTTTTGTGGAAAATGCCAGTCATGAGTTACGAACTCCACTCGCAGTTTTGCAAAATCGCTTAGAG
ACCCTTTTTCGTAAGCCAGAAGCTACCATTATGGATGTGAGCGAAAGCATTGCATCGAGTTTGGAAGAAGTCCGAAATAT
GCGTTTTTTAACGACAAGCTTGCTGAACTTAGCTCGGAGAGATGATGGGATTAAGCCGGAGCTTGCAGAAGTTCCAACTA
GCTTTTTTAATACAACTTTCACAAACTACGAGATGATTGCTTCGGAAAATAATCGTGTCTTCCGTTTTGAAAATCGTATC
CATCGAACAATTGTCACAGATCAGCTTCTTCTGAAACAACTGATGACCATTCTTTTCGATAATGCCGTCAAGTATACTGA
GGAGGATGGTGAAATTGATTTTCTTATCTCGGCGACCGATCGCAATCTTTATTTACTTGTTTCTGATAATGGAATCGGTA
TTTCGACAGAAGATAAAAAGAAAATTTTTGACCGTTTTTATCGAGTAGACAAAGCTAGAACCCGGCAAAAAGGTGGTTTT
GGTTTAGGATTATCCCTAGCCAAGCAAATTGTAGATGCTCTAAAAGGAACTGTTACTGTCAAAGATAATAAACCCAAGGG
AACAATCTTTGAAGTGAAGATTGCCATTCAGACACCAACCATCTAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(327-434)

His Kinase A (phospho-acceptor) domain (HisKA)

(217-283)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

99.773

99.773

0.995
  ciaH Streptococcus pneumoniae D39

99.773

99.773

0.995
  ciaH Streptococcus pneumoniae R6

99.773

99.773

0.995
  ciaH Streptococcus pneumoniae TIGR4

99.773

99.773

0.995
  ciaH Streptococcus mutans UA159

55.632

98.639

0.549