Detailed information NTG0068218

Bioinformatically predicted

Overview

• Name: vicK
• Type: Regulator
• Locus tag: JMUB1235_RS02320
• Genome accession: NZ_AP017629
• Coordinates: 431489..432841 (+)
• Length: 450 a.a.
• NCBI ID: WP_002990673.1
• Uniprot ID: A0A660A508
• Organism: Streptococcus pyogenes strain JMUB1235
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 426489..437841

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
JMUB1235_RS02295 (JMUB1235_0454)	-	426638..426787 (+)	150	WP_002990686.1	hypothetical protein	-
JMUB1235_RS02300 (JMUB1235_0455)	-	427182..428330 (+)	1149	WP_031488431.1	acetyl-CoA C-acyltransferase	-
JMUB1235_RS02305 (JMUB1235_0456)	-	428287..429534 (+)	1248	WP_023612155.1	AMP-binding protein	-
JMUB1235_RS02310 (JMUB1235_0457)	-	429590..430624 (+)	1035	WP_011284595.1	DUF3114 domain-containing protein	-
JMUB1235_RS02315 (JMUB1235_0458)	vicR	430786..431496 (+)	711	WP_002985645.1	response regulator YycF	Regulator
JMUB1235_RS02320 (JMUB1235_0459)	vicK	431489..432841 (+)	1353	WP_002990673.1	cell wall metabolism sensor histidine kinase VicK	Regulator
JMUB1235_RS02325 (JMUB1235_0460)	vicX	432845..433654 (+)	810	WP_002985641.1	MBL fold metallo-hydrolase	Regulator
JMUB1235_RS02330 (JMUB1235_0461)	rnc	434086..434778 (+)	693	WP_002985639.1	ribonuclease III	-

Sequence

Protein

• Length: 450 a.a.
• Molecular weight: 51391.82 Da
• Isoelectric Point: 5.4026

>NTDB_id=68218 JMUB1235_RS02320 WP_002990673.1 431489..432841(+) (vicK) [Streptococcus pyogenes strain JMUB1235]
MTRDIIGNLSTFELAILILLVFVAFYFIHLAVRDYRNARIIRMMSHKIRDLINGRYTDIIDEKADIELMELSDQLNDLSD
VFRLTHENLAQEKNRLASILAYMSDGVLATDRSGKIIMINETARKQLNLSKEEALKKNITDLLEGDTSYTYRDLVSKTPV
VTVNSRNDMGEFVSLRLRFALNRRESGFISGLVVVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALK
EDIAPSFIKVSLDETNRMMRMISDLLNLSRIDNQVTQLAVEMTNFTAFITSILNRFDLVKNQHTGTGKVYEIVRDYPITS
VWLEIDNDKMTQVIENILNNAIKYSPDGGKITVRMKTTDTQLIISISDQGLGIPKTDLPLIFDRFYRVDKARSRAQGGTG
LGLAIAKEIIKQHHGFIWAKSDYGKGSTFTIVLPYEKDAAIYEEWEEDVD

Nucleotide

• Length: 1353 bp

>NTDB_id=68218 JMUB1235_RS02320 WP_002990673.1 431489..432841(+) (vicK) [Streptococcus pyogenes strain JMUB1235]
ATGACTAGAGATATCATTGGAAACTTATCCACATTTGAATTAGCGATCCTTATCTTACTTGTTTTTGTTGCTTTTTACTT
TATCCATCTTGCGGTGCGTGACTACCGAAATGCACGTATTATTCGGATGATGAGCCATAAAATCCGAGACTTGATTAATG
GTCGCTATACTGATATAATCGACGAAAAAGCAGACATTGAGTTAATGGAGCTTTCAGACCAGTTAAATGACCTGTCAGAT
GTTTTTCGCTTGACGCATGAAAATCTTGCCCAAGAAAAAAATCGCTTGGCAAGTATTTTGGCTTATATGTCAGATGGTGT
ACTTGCTACAGACCGGTCTGGTAAAATCATCATGATTAACGAGACAGCTCGCAAGCAATTAAATTTAAGTAAAGAAGAGG
CACTAAAGAAAAACATTACAGATTTGTTAGAAGGTGATACTTCATATACCTACCGTGATTTGGTATCCAAAACACCAGTG
GTAACTGTTAATAGCCGAAATGATATGGGTGAGTTTGTCTCATTACGTTTGCGCTTTGCGTTGAATAGGAGAGAGAGTGG
TTTTATTTCGGGCTTGGTTGTGGTGCTCCATGACACCACAGAACAAGAAAAAGAAGAACGTGAACGCCGTCTTTTTGTCT
CTAATGTAAGTCATGAATTAAGGACCCCTTTAACTTCGGTTAAATCCTACTTGGAGGCTCTTGATGAAGGTGCACTTAAA
GAAGATATTGCTCCAAGTTTCATAAAAGTTTCTCTTGATGAAACTAATCGGATGATGCGTATGATTTCAGATCTTTTAAA
CCTGTCTCGGATTGATAATCAAGTAACCCAATTAGCAGTAGAGATGACTAATTTTACTGCTTTTATAACTTCTATTTTAA
ACAGATTTGATTTGGTTAAAAATCAGCATACAGGTACAGGAAAAGTCTATGAAATTGTAAGAGATTACCCTATTACCTCT
GTCTGGCTTGAAATTGATAATGATAAAATGACACAGGTTATCGAGAATATTTTGAACAATGCCATTAAGTATTCTCCAGA
TGGTGGAAAAATTACAGTCCGTATGAAAACAACAGATACCCAATTAATTATTTCCATTTCAGACCAAGGACTAGGTATCC
CTAAAACAGATTTGCCTCTTATTTTTGATCGGTTCTATCGTGTAGACAAGGCAAGAAGTCGTGCCCAAGGAGGGACCGGC
CTAGGCCTTGCCATTGCTAAAGAAATCATCAAGCAGCACCATGGCTTTATCTGGGCTAAGAGTGACTATGGTAAAGGATC
GACCTTTACTATTGTCTTGCCTTATGAAAAAGATGCAGCCATCTATGAAGAATGGGAGGAAGATGTAGACTAA

Domains

Predicted by InterproScan.

• His Kinase A (phospho-acceptor) domain (HisKA) (209-273)

• PAS fold (PAS) (95-162)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (326-436)

3D structure

• AlphaFold DB: A0A660A508

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicK	Streptococcus mutans UA159	72.705	92	0.669
micB	Streptococcus pneumoniae Cp1015	67.765	94.444	0.64