Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   SCSC_RS04710 Genome accession   NZ_AP014647
Coordinates   950296..951642 (-) Length   448 a.a.
NCBI ID   WP_006269417.1    Uniprot ID   -
Organism   Streptococcus constellatus subsp. constellatus strain CCUG 24889     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 945296..956642
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SCSC_RS04690 (SCSC_0971) rpsT 945735..945971 (+) 237 WP_006269392.1 30S ribosomal protein S20 -
  SCSC_RS04695 (SCSC_0972) - 946036..946545 (+) 510 WP_037565509.1 DNA topology modulation protein -
  SCSC_RS04700 (SCSC_0973) - 946571..948199 (-) 1629 WP_006269388.1 M20/M25/M40 family metallo-hydrolase -
  SCSC_RS04705 (SCSC_0974) - 948377..949825 (+) 1449 WP_006269401.1 alpha-amylase -
  SCSC_RS04710 (SCSC_0975) ciaH 950296..951642 (-) 1347 WP_006269417.1 HAMP domain-containing sensor histidine kinase Regulator
  SCSC_RS04715 (SCSC_0976) ciaR 951632..952306 (-) 675 WP_003068917.1 response regulator transcription factor Regulator
  SCSC_RS04720 (SCSC_0977) - 952570..953013 (-) 444 WP_006269399.1 hypothetical protein -
  SCSC_RS04725 (SCSC_0978) - 953341..954099 (-) 759 WP_006269377.1 alpha/beta hydrolase -
  SCSC_RS04735 (SCSC_0980) rplS 954344..954691 (-) 348 WP_003024326.1 50S ribosomal protein L19 -
  SCSC_RS04740 (SCSC_0981) - 954841..955800 (-) 960 WP_006269422.1 ROK family glucokinase -

Sequence

Protein


Download         Length: 448 a.a.        Molecular weight: 50909.67 Da        Isoelectric Point: 10.0789

>NTDB_id=66564 SCSC_RS04710 WP_006269417.1 950296..951642(-) (ciaH) [Streptococcus constellatus subsp. constellatus strain CCUG 24889]
MLNKLKKAWYADDFSYFIRNFGIFTLIFSAMTLIIIQVMRSSLYTTVDNNLKSLSQDSASVINLALARKVGLDQKSENGE
PKSGTADKELTDKPNVSANTEVILFDKNYKPIITSNNFLGFNKLSFNRKQLDHIRQIQVKSNYGREETYRMILFEVKLPN
LETNVKYAAVFINISQLEQTSQNHEQLIVVVMISFWGISLIASVYLARVSVKPLLESIQKQKSFVENASHELRTPLAVLQ
NRLETLFRKPEATIMEASESIASSLDEVRNMKMLTTNLLNLARRDDGIKPEIGDIEPNFFNTTFTNYEMVAAENGKIFRF
DNRIHRVIKTDKTLLKQLMTILFDNALKYTDEDGVIELTISANDRNLFLKVSDNGPGISTADKKKIFDRFYRVDKARTRQ
TGGFGLGLSLAKQITEALKGTIAVKDNNPKGTIFEVKIAIRTDNKKKK

Nucleotide


Download         Length: 1347 bp        

>NTDB_id=66564 SCSC_RS04710 WP_006269417.1 950296..951642(-) (ciaH) [Streptococcus constellatus subsp. constellatus strain CCUG 24889]
ATGCTGAATAAACTAAAAAAAGCATGGTATGCGGATGATTTTTCTTATTTCATTCGCAATTTTGGTATTTTTACTCTCAT
TTTCTCAGCTATGACCTTGATTATCATTCAAGTTATGCGCTCAAGCCTTTATACAACGGTAGATAACAATTTAAAAAGCT
TGAGTCAAGATTCGGCTTCTGTGATTAATTTAGCACTTGCTCGAAAAGTAGGGCTAGATCAAAAGTCAGAAAATGGAGAG
CCTAAAAGTGGAACAGCTGACAAAGAGTTGACAGATAAACCAAATGTTAGTGCCAACACAGAAGTTATTTTATTTGATAA
GAATTATAAGCCGATTATTACAAGCAATAATTTCTTAGGGTTCAATAAACTTTCCTTTAATAGGAAGCAATTAGACCACA
TTCGTCAGATTCAAGTAAAAAGCAATTATGGTCGAGAAGAAACCTATCGAATGATTTTATTTGAGGTAAAACTGCCTAAT
TTGGAGACCAATGTCAAATACGCAGCGGTTTTTATCAATATCAGTCAATTGGAACAAACTAGTCAAAATCATGAACAGTT
GATTGTGGTGGTGATGATTAGTTTCTGGGGAATTTCCTTGATTGCTAGTGTTTATCTTGCACGGGTCAGTGTTAAACCTC
TTTTAGAAAGCATTCAAAAGCAAAAAAGTTTTGTCGAAAACGCTAGTCATGAGTTGCGTACACCTCTAGCTGTGTTGCAA
AATCGTTTGGAGACTTTGTTTAGAAAGCCAGAAGCTACTATTATGGAAGCCAGTGAAAGCATTGCTTCTAGTTTGGATGA
AGTGCGAAATATGAAAATGTTGACGACAAACTTACTCAATCTAGCACGGCGTGACGACGGGATTAAACCAGAAATTGGCG
ATATCGAGCCAAATTTCTTTAATACAACTTTCACCAACTATGAAATGGTTGCCGCAGAGAATGGGAAAATTTTCCGATTT
GACAATAGGATTCACCGCGTAATTAAAACGGATAAAACCTTACTGAAGCAATTGATGACTATCTTGTTTGATAATGCCCT
GAAATATACAGATGAAGATGGTGTGATTGAATTGACAATTTCTGCAAATGATCGAAATTTGTTTTTGAAGGTTTCGGATA
ATGGTCCGGGGATTAGTACGGCAGATAAGAAAAAGATTTTTGATCGTTTTTATCGTGTTGATAAAGCACGGACTCGGCAG
ACAGGTGGTTTTGGTTTAGGGTTGTCGCTTGCAAAGCAAATCACAGAAGCTCTTAAAGGAACCATTGCAGTGAAAGACAA
TAATCCTAAAGGAACTATTTTTGAGGTGAAGATTGCGATTCGAACGGATAATAAAAAGAAAAAATAG

Domains

Predicted by InterproScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(222-287)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(331-438)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

70.536

100

0.705
  ciaH Streptococcus pneumoniae D39

70.536

100

0.705
  ciaH Streptococcus pneumoniae R6

70.536

100

0.705
  ciaH Streptococcus pneumoniae TIGR4

70.536

100

0.705
  ciaH Streptococcus mutans UA159

55.556

98.438

0.547

Multiple sequence alignment