Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   MKD39_RS04815 Genome accession   NZ_CP092478
Coordinates   993877..994506 (+) Length   209 a.a.
NCBI ID   WP_011275376.1    Uniprot ID   Q4L7J5
Organism   Staphylococcus haemolyticus strain CGMH-SH51     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 988877..999506
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MKD39_RS04790 (MKD39_04785) - 989578..990435 (-) 858 WP_011275370.1 SDR family oxidoreductase -
  MKD39_RS04795 (MKD39_04790) - 990507..991519 (-) 1013 Protein_947 HoxN/HupN/NixA family nickel/cobalt transporter -
  MKD39_RS04800 (MKD39_04795) - 991732..992118 (+) 387 WP_011275373.1 hypothetical protein -
  MKD39_RS04805 (MKD39_04800) liaF 992143..992844 (+) 702 WP_011275374.1 cell wall-active antibiotics response protein LiaF -
  MKD39_RS04810 (MKD39_04805) vraS 992841..993887 (+) 1047 WP_011275375.1 sensor histidine kinase Regulator
  MKD39_RS04815 (MKD39_04810) vraR 993877..994506 (+) 630 WP_011275376.1 two-component system response regulator VraR Regulator
  MKD39_RS04820 (MKD39_04815) - 994570..995781 (-) 1212 WP_011275377.1 YihY/virulence factor BrkB family protein -
  MKD39_RS04825 (MKD39_04820) - 995978..996262 (-) 285 WP_011275378.1 YtxH domain-containing protein -
  MKD39_RS04830 (MKD39_04825) - 996268..996732 (-) 465 WP_011275379.1 low molecular weight protein-tyrosine-phosphatase -
  MKD39_RS04835 (MKD39_04830) - 996874..997083 (+) 210 WP_011275380.1 DUF1128 domain-containing protein -
  MKD39_RS04840 (MKD39_04835) - 997097..998344 (+) 1248 WP_011275381.1 aminopeptidase -
  MKD39_RS04845 (MKD39_04840) - 998377..998910 (+) 534 WP_011275382.1 acyl-CoA thioesterase -

Sequence

Protein


Download         Length: 209 a.a.        Molecular weight: 23575.23 Da        Isoelectric Point: 5.0058

>NTDB_id=657933 MKD39_RS04815 WP_011275376.1 993877..994506(+) (vraR) [Staphylococcus haemolyticus strain CGMH-SH51]
MTIKVLFVDDHEMVRIGISSYLSTQSDIEIVGEGESGKDAIAKAHELKPDLILMDLLMDDMDGVEATTQIKKDLPHIKVV
MLTSFIEDKEVYRALDAGVDSYILKTTSASDIADAVRKTFNGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIA
KGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ

Nucleotide


Download         Length: 630 bp        

>NTDB_id=657933 MKD39_RS04815 WP_011275376.1 993877..994506(+) (vraR) [Staphylococcus haemolyticus strain CGMH-SH51]
ATGACGATTAAAGTTTTGTTCGTTGATGACCATGAAATGGTTCGAATTGGGATATCAAGTTATCTATCAACACAATCTGA
CATTGAGATAGTTGGAGAAGGGGAATCTGGTAAAGATGCCATTGCAAAAGCTCATGAATTAAAACCTGATTTAATTCTTA
TGGATTTATTAATGGATGATATGGATGGCGTTGAAGCAACTACTCAAATCAAAAAAGATTTGCCACATATTAAAGTTGTA
ATGTTAACTAGTTTTATTGAAGATAAAGAGGTATATAGAGCATTAGATGCTGGTGTAGATAGCTATATTTTAAAAACGAC
TAGTGCTAGTGATATAGCCGACGCAGTACGCAAAACTTTTAATGGTGAATCCGTATTTGAACCAGAAGTTTTAGTTAAGA
TGCGTAACAGAATGAAGAAACGTGCAGAATTATATGAAATGCTGACTGAGCGTGAAATGGAAATTTTATTATTAATTGCA
AAAGGTTATTCAAATCAAGAAATAGCGAGTGCTTCTCATATTACAATTAAAACCGTTAAAACTCATGTAAGTAATATATT
GAGTAAATTAGAAGTACAAGATAGAACACAAGCCGTAATTTATGCATTCCAACATAATTTGATTCAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-116)

Bacterial regulatory proteins, luxR family (GerE)

(147-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q4L7J5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

95.694

100

0.957
  degU Bacillus subtilis subsp. subtilis str. 168

33.929

100

0.364