Detailed information NTG0657932

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: MKD39_RS04810
• Genome accession: NZ_CP092478
• Coordinates: 992841..993887 (+)
• Length: 348 a.a.
• NCBI ID: WP_011275375.1
• Uniprot ID: A0A2A1K920
• Organism: Staphylococcus haemolyticus strain CGMH-SH51
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 987841..998887

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MKD39_RS04785 (MKD39_04780)	map	988701..989453 (+)	753	WP_011275369.1	type I methionyl aminopeptidase	-
MKD39_RS04790 (MKD39_04785)	-	989578..990435 (-)	858	WP_011275370.1	SDR family oxidoreductase	-
MKD39_RS04795 (MKD39_04790)	-	990507..991519 (-)	1013	Protein_947	HoxN/HupN/NixA family nickel/cobalt transporter	-
MKD39_RS04800 (MKD39_04795)	-	991732..992118 (+)	387	WP_011275373.1	hypothetical protein	-
MKD39_RS04805 (MKD39_04800)	liaF	992143..992844 (+)	702	WP_011275374.1	cell wall-active antibiotics response protein LiaF	-
MKD39_RS04810 (MKD39_04805)	vraS	992841..993887 (+)	1047	WP_011275375.1	sensor histidine kinase	Regulator
MKD39_RS04815 (MKD39_04810)	vraR	993877..994506 (+)	630	WP_011275376.1	two-component system response regulator VraR	Regulator
MKD39_RS04820 (MKD39_04815)	-	994570..995781 (-)	1212	WP_011275377.1	YihY/virulence factor BrkB family protein	-
MKD39_RS04825 (MKD39_04820)	-	995978..996262 (-)	285	WP_011275378.1	YtxH domain-containing protein	-
MKD39_RS04830 (MKD39_04825)	-	996268..996732 (-)	465	WP_011275379.1	low molecular weight protein-tyrosine-phosphatase	-
MKD39_RS04835 (MKD39_04830)	-	996874..997083 (+)	210	WP_011275380.1	DUF1128 domain-containing protein	-
MKD39_RS04840 (MKD39_04835)	-	997097..998344 (+)	1248	WP_011275381.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40179.58 Da
• Isoelectric Point: 6.0550

>NTDB_id=657932 MKD39_RS04810 WP_011275375.1 992841..993887(+) (vraS) [Staphylococcus haemolyticus strain CGMH-SH51]
MNHYLRAIGSMLILVYSMLTAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLVIILLCIIVGSILAYKINQQNQWIKS
QIEHAIEGETVGINDQNIELYNETIDLYQTLVPLNQELHRLRMKTQNLTNENYNMNDVKVKKIIENERQRLARELHDSVS
QQLFAASMMLSAIKETKLEAPLDQQIPVLEKMVQESQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVIHDI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQQDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNREDDNNDD

Nucleotide

• Length: 1047 bp

>NTDB_id=657932 MKD39_RS04810 WP_011275375.1 992841..993887(+) (vraS) [Staphylococcus haemolyticus strain CGMH-SH51]
ATGAACCACTACTTAAGAGCTATCGGTTCAATGCTTATACTAGTTTATAGCATGTTAACCGCGTTCTTATTTATAGATAA
AGTATTTGTTAATATTATCTATTTCCAAGGTATGTTTTATACTCAAATTTTTGGGATACCTGTTTTTCTATTTTTAAATT
TAGTCATCATTTTACTTTGTATTATAGTAGGTTCAATTCTCGCATATAAAATTAATCAACAAAATCAGTGGATTAAGTCG
CAAATTGAGCATGCCATTGAAGGAGAAACAGTAGGTATCAATGATCAAAACATTGAGCTCTATAACGAAACCATAGATCT
TTATCAAACATTAGTTCCTCTAAATCAAGAGTTGCACCGTTTACGAATGAAAACGCAAAACTTAACTAATGAAAATTACA
ATATGAATGATGTCAAAGTTAAGAAAATCATTGAGAATGAACGACAGAGATTAGCTCGCGAGTTACATGACTCTGTAAGT
CAACAACTTTTTGCAGCAAGTATGATGTTATCTGCTATAAAAGAAACAAAATTAGAGGCACCGCTTGATCAACAAATACC
AGTTTTAGAGAAAATGGTTCAGGAATCTCAACTTGAAATGCGCGCATTATTACTTCATTTGAGACCTTTAGGACTAAAAG
ATAAATCACTAGGTGAAGGTATCAAAGATTTAGTTATTGATTTGCAAAAGAAAGTGCCTATGAAAGTCATACACGATATT
CAAGATTTCAAGGTTCCTAAAGGTATAGAAGATCATTTATTTAGAATTACACAAGAGGCTATATCAAATACGTTAAGACA
TTCTAATGGAACTAAAGTCACAGTGGAATTATTTAACCAACAAGATTATCTATTACTTCGAATTCAAGATAATGGTAAGG
GATTCAATGTTGACGAGAAATTAGAACAAAGTTATGGATTAAAAAATATGAGAGAACGCGCATTAGAAATTGGTGCGACA
TTCCATATTGTTTCGTTACCGGATTCTGGAACGAGAATAGAAGTTAAAGCACCATTAAATAGGGAGGATGATAATAATGA
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase (HisKA_3) (147-210)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

3D structure

• AlphaFold DB: A0A2A1K920

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	91.643	99.713	0.914