Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   OG420_RS29675 Genome accession   NZ_CP108147
Coordinates   6485199..6486059 (+) Length   286 a.a.
NCBI ID   WP_405880669.1    Uniprot ID   -
Organism   Streptomyces sp. NBC_00169     
Function   degrading CSP; selective degradation of ComEA and ComEC (predicted from homology)   
Competence regulation

Genomic Context

Location: 6480199..6491059
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  OG420_RS29660 (OG420_29630) sigE 6480903..6481604 (+) 702 WP_019072074.1 RNA polymerase sigma factor SigE -
  OG420_RS29665 (OG420_29635) - 6481601..6482572 (+) 972 WP_328829265.1 anti-sigma factor -
  OG420_RS29670 (OG420_29640) - 6483001..6483504 (-) 504 WP_328932662.1 hypothetical protein -
  OG420_RS29675 (OG420_29645) htrA 6485199..6486059 (+) 861 WP_405880669.1 S1C family serine protease Regulator
  OG420_RS29680 (OG420_29650) - 6486261..6486698 (+) 438 WP_266772214.1 sec-independent translocase -
  OG420_RS29685 (OG420_29655) - 6486980..6487639 (+) 660 WP_328829264.1 hypothetical protein -
  OG420_RS29690 (OG420_29660) - 6487718..6488851 (-) 1134 WP_266772217.1 Mrp/NBP35 family ATP-binding protein -
  OG420_RS29695 (OG420_29665) - 6488895..6489488 (-) 594 WP_328829263.1 DUF1003 domain-containing protein -
  OG420_RS29700 (OG420_29670) - 6489478..6490827 (-) 1350 WP_328932660.1 magnesium transporter MgtE N-terminal domain-containing protein -

Sequence

Protein


Download         Length: 286 a.a.        Molecular weight: 28813.97 Da        Isoelectric Point: 5.5739

>NTDB_id=655000 OG420_RS29675 WP_405880669.1 6485199..6486059(+) (htrA) [Streptomyces sp. NBC_00169]
MSGDDGSGTGTGIVLDGRGDILTNNHVVRAGGGGGAISVRFSGGQTVKGDVVGRDVGYDLAVVRVHGVRGLRAMPLGNSD
NVRVGDPVVAIGAPFGLDNTVTAGIVSAKERPVTTDGDASDGSGVSYLDALQTDAPINPGNSGGPLLDARGLLVGVNSAI
RSADQQDGDGEGSSQSGSVGLGFAIPVNQAKRVAEELINHGKATHPVIGVTLDLDYAGDGARVATPKAGLRAGDVITRVD
GQPVHSGDELVVRTRAHRPGDHLRLTLRRGGQDMTLSLVLGSATGD

Nucleotide


Download         Length: 861 bp        

>NTDB_id=655000 OG420_RS29675 WP_405880669.1 6485199..6486059(+) (htrA) [Streptomyces sp. NBC_00169]
GTGAGTGGGGACGACGGGTCGGGGACCGGGACCGGGATCGTGTTGGACGGTCGCGGGGACATCCTCACCAACAACCATGT
CGTGCGGGCCGGGGGCGGTGGCGGGGCGATATCCGTTCGGTTCAGCGGGGGGCAGACCGTCAAGGGGGACGTGGTCGGGC
GGGATGTCGGGTACGACCTCGCTGTCGTGCGGGTGCACGGCGTGCGGGGGCTCAGGGCGATGCCGCTCGGGAATTCCGAC
AATGTGCGGGTGGGTGACCCCGTCGTCGCGATCGGGGCGCCGTTCGGGCTCGACAACACCGTGACCGCCGGGATCGTCAG
TGCCAAGGAACGGCCCGTCACGACCGACGGGGACGCGTCGGACGGGAGCGGCGTGTCGTATCTCGATGCTCTCCAGACCG
ACGCGCCGATCAATCCCGGGAACTCCGGTGGGCCGTTGCTCGACGCGCGGGGGCTGCTCGTCGGGGTCAACTCCGCCATC
CGGTCCGCCGATCAGCAGGACGGGGACGGGGAGGGCAGTTCGCAGAGCGGGTCGGTCGGGCTCGGGTTTGCCATTCCCGT
CAATCAGGCCAAGCGGGTTGCCGAGGAGTTGATCAATCACGGGAAGGCGACTCATCCCGTCATCGGGGTCACCCTCGACC
TCGACTACGCCGGCGACGGCGCCCGTGTCGCCACGCCCAAGGCCGGGCTCAGGGCGGGGGACGTCATCACGCGGGTCGAC
GGTCAGCCGGTGCACTCCGGTGACGAGCTCGTCGTCAGGACGCGTGCTCACCGGCCCGGTGACCACCTGCGGCTGACGCT
GCGGCGCGGCGGCCAGGACATGACCTTGTCGCTGGTGCTCGGCTCCGCGACCGGTGATTGA

Domains

Predicted by InterProScan.

Trypsin-like peptidase domain (Trypsin_2)

(10-156)

PDZ domain (PDZ_2)

(224-278)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus pneumoniae Rx1

34.314

100

0.367
  htrA Streptococcus pneumoniae D39

34.314

100

0.367
  htrA Streptococcus pneumoniae R6

34.314

100

0.367
  htrA Streptococcus pneumoniae TIGR4

34.314

100

0.367
  htrA Streptococcus mitis NCTC 12261

34.314

100

0.367