Detailed information
Bioinformatically predicted
Overview
| Name | comM | Type | Regulator |
| Locus tag | L3474_RS08825 | Genome accession | NZ_CP091450 |
| Coordinates | 1737451..1738071 (-) | Length | 206 a.a. |
| NCBI ID | WP_000839909.1 | Uniprot ID | A0A098Z2X2 |
| Organism | Streptococcus pneumoniae strain 3641/15 | ||
| Function | fratricide immunity (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1725906..1769783 | 1737451..1738071 | within | 0 |
Gene organization within MGE regions
Location: 1725906..1769783
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L3474_RS08755 (L3474_08695) | - | 1726203..1726754 (-) | 552 | WP_001111247.1 | hypothetical protein | - |
| L3474_RS08760 (L3474_08700) | - | 1726744..1726941 (-) | 198 | WP_000890144.1 | hypothetical protein | - |
| L3474_RS08765 (L3474_08705) | - | 1726945..1727739 (-) | 795 | WP_001101215.1 | hypothetical protein | - |
| L3474_RS08770 (L3474_08710) | - | 1728147..1728572 (-) | 426 | WP_000204068.1 | hypothetical protein | - |
| L3474_RS08775 (L3474_08715) | - | 1728701..1729060 (-) | 360 | WP_000749821.1 | ImmA/IrrE family metallo-endopeptidase | - |
| L3474_RS08780 (L3474_08720) | - | 1729106..1729312 (-) | 207 | WP_000366087.1 | hypothetical protein | - |
| L3474_RS08785 (L3474_08725) | - | 1729299..1729460 (-) | 162 | WP_000289348.1 | helix-turn-helix domain-containing protein | - |
| L3474_RS08790 (L3474_08730) | lytA | 1729819..1730775 (-) | 957 | WP_000405240.1 | N-acetylmuramoyl-L-alanine amidase LytA | - |
| L3474_RS08795 (L3474_08735) | - | 1731151..1732521 (-) | 1371 | WP_001036271.1 | MATE family efflux transporter | - |
| L3474_RS08800 (L3474_08740) | recA | 1732828..1733994 (-) | 1167 | WP_001085462.1 | recombinase RecA | Machinery gene |
| L3474_RS08805 (L3474_08745) | cinA | 1734049..1735305 (-) | 1257 | WP_000642704.1 | competence/damage-inducible protein A | Machinery gene |
| L3474_RS08810 (L3474_08750) | brpA | 1735390..1736406 (-) | 1017 | WP_000239278.1 | biofilm formation/cell division transcriptional regulator BrpA | - |
| L3474_RS08815 (L3474_08755) | - | 1736414..1736932 (-) | 519 | WP_000455536.1 | GNAT family N-acetyltransferase | - |
| L3474_RS08820 (L3474_08760) | tsaE | 1736922..1737365 (-) | 444 | WP_000288230.1 | tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE | - |
| L3474_RS08825 (L3474_08765) | comM | 1737451..1738071 (-) | 621 | WP_000839909.1 | hypothetical protein | Regulator |
| L3474_RS08830 (L3474_08770) | - | 1738377..1739240 (-) | 864 | WP_001093609.1 | helix-turn-helix domain-containing protein | - |
| L3474_RS08835 | - | 1739432..1739602 (+) | 171 | WP_001227863.1 | PhrA family quorum-sensing system peptide | - |
| L3474_RS08840 (L3474_08775) | - | 1740004..1740318 (+) | 315 | WP_000420682.1 | YdcP family protein | - |
| L3474_RS08845 (L3474_08780) | - | 1740334..1740720 (+) | 387 | WP_000985015.1 | YdcP family protein | - |
| L3474_RS08850 (L3474_08785) | - | 1740749..1742134 (+) | 1386 | WP_000813494.1 | FtsK/SpoIIIE domain-containing protein | - |
| L3474_RS08855 (L3474_08790) | - | 1742137..1742289 (+) | 153 | WP_000879507.1 | hypothetical protein | - |
| L3474_RS08860 (L3474_08795) | mobT | 1742312..1743532 (+) | 1221 | WP_001826381.1 | MobT family relaxase | - |
| L3474_RS08865 (L3474_08800) | - | 1743522..1743689 (+) | 168 | WP_000502600.1 | MLS leader peptide | - |
| L3474_RS08870 (L3474_08805) | - | 1743738..1743821 (+) | 84 | WP_001814874.1 | 23S rRNA methyltransferase attenuation leader peptide | - |
| L3474_RS08875 (L3474_08810) | erm(B) | 1743946..1744683 (+) | 738 | WP_001038795.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) | - |
| L3474_RS08880 (L3474_08815) | - | 1744940..1746187 (-) | 1248 | WP_000019067.1 | ISL3 family transposase | - |
| L3474_RS08885 (L3474_08820) | - | 1746367..1746588 (+) | 222 | WP_001009056.1 | hypothetical protein | - |
| L3474_RS08890 (L3474_08825) | - | 1746705..1747202 (+) | 498 | WP_000342539.1 | antirestriction protein ArdA | - |
| L3474_RS08895 (L3474_08830) | - | 1747291..1747683 (+) | 393 | WP_000723888.1 | conjugal transfer protein | - |
| L3474_RS08900 (L3474_08835) | - | 1747667..1750114 (+) | 2448 | WP_000331160.1 | ATP-binding protein | - |
| L3474_RS08905 (L3474_08840) | - | 1750117..1752294 (+) | 2178 | WP_001814875.1 | CD3337/EF1877 family mobilome membrane protein | - |
| L3474_RS08910 (L3474_08845) | - | 1752291..1753292 (+) | 1002 | WP_000769868.1 | lysozyme family protein | - |
| L3474_RS08915 (L3474_08850) | - | 1753289..1754221 (+) | 933 | WP_001224318.1 | conjugal transfer protein | - |
| L3474_RS10765 | - | 1754535..1754582 (+) | 48 | Protein_1750 | hypothetical protein | - |
| L3474_RS08925 (L3474_08860) | tet(M) | 1754598..1756517 (+) | 1920 | WP_000691729.1 | tetracycline resistance ribosomal protection protein Tet(M) | - |
| L3474_RS08930 (L3474_08865) | - | 1756881..1757126 (+) | 246 | WP_001813542.1 | hypothetical protein | - |
| L3474_RS08935 (L3474_08870) | - | 1757123..1757458 (+) | 336 | WP_000806926.1 | hypothetical protein | - |
| L3474_RS08940 (L3474_08875) | - | 1757471..1757839 (+) | 369 | WP_000567222.1 | hypothetical protein | - |
| L3474_RS08945 (L3474_08880) | - | 1757826..1758125 (+) | 300 | WP_001072467.1 | DUF5960 family protein | - |
| L3474_RS08950 (L3474_08885) | msr(D) | 1758243..1759706 (-) | 1464 | WP_000420313.1 | ABC-F type ribosomal protection protein Msr(D) | - |
| L3474_RS08955 (L3474_08890) | mef(A) | 1759826..1761043 (-) | 1218 | WP_000417519.1 | macrolide efflux MFS transporter Mef(A) | - |
| L3474_RS08960 (L3474_08895) | - | 1761429..1761599 (-) | 171 | WP_000873143.1 | hypothetical protein | - |
| L3474_RS08965 (L3474_08900) | - | 1762121..1762312 (+) | 192 | WP_001860868.1 | cysteine-rich KTR domain-containing protein | - |
| L3474_RS08970 (L3474_08905) | - | 1762372..1762725 (-) | 354 | WP_001227347.1 | helix-turn-helix transcriptional regulator | - |
| L3474_RS08975 (L3474_08910) | - | 1763230..1763652 (+) | 423 | WP_000804885.1 | sigma-70 family RNA polymerase sigma factor | - |
| L3474_RS08980 (L3474_08915) | - | 1763649..1763879 (+) | 231 | WP_000857133.1 | helix-turn-helix domain-containing protein | - |
| L3474_RS08985 (L3474_08920) | - | 1764105..1764356 (-) | 252 | WP_001845478.1 | hypothetical protein | - |
| L3474_RS08990 (L3474_08925) | - | 1764340..1764543 (+) | 204 | WP_000814511.1 | excisionase | - |
| L3474_RS08995 (L3474_08930) | - | 1764625..1765842 (+) | 1218 | WP_001291561.1 | tyrosine-type recombinase/integrase | - |
| L3474_RS09000 (L3474_08935) | - | 1766733..1768748 (+) | 2016 | WP_000732395.1 | DUF1430 domain-containing protein | - |
| L3474_RS09005 (L3474_08940) | - | 1768750..1769382 (+) | 633 | WP_000571425.1 | ABC transporter ATP-binding protein | - |
Sequence
Protein
Download Length: 206 a.a. Molecular weight: 23540.66 Da Isoelectric Point: 10.1254
>NTDB_id=651273 L3474_RS08825 WP_000839909.1 1737451..1738071(-) (comM) [Streptococcus pneumoniae strain 3641/15]
MKSMRILFLLALIQISLSSCFLWKECILSFKQSTAFFIGSMVFVSGICAGVNYLYTRKQEVHSVLASKKSVKLFYSMLLL
INLLGAVLVLSDNLFIKNTLQQELVDFLLPSFFFLFGLDLLIFLPLKKYVRDFLAMLDRKKTVLVTILATLLFLRNPMTI
VSLLIYTGLGLFFAAYLVPNSVKKEVSFYGHIFRDLVLVIVTLIFF
MKSMRILFLLALIQISLSSCFLWKECILSFKQSTAFFIGSMVFVSGICAGVNYLYTRKQEVHSVLASKKSVKLFYSMLLL
INLLGAVLVLSDNLFIKNTLQQELVDFLLPSFFFLFGLDLLIFLPLKKYVRDFLAMLDRKKTVLVTILATLLFLRNPMTI
VSLLIYTGLGLFFAAYLVPNSVKKEVSFYGHIFRDLVLVIVTLIFF
Nucleotide
Download Length: 621 bp
>NTDB_id=651273 L3474_RS08825 WP_000839909.1 1737451..1738071(-) (comM) [Streptococcus pneumoniae strain 3641/15]
ATGAAATCAATGAGAATCTTATTTTTGTTAGCTTTAATTCAAATCAGTTTGAGTAGCTGTTTCCTATGGAAGGAATGCAT
CTTGTCCTTTAAACAAAGTACAGCTTTTTTCATCGGAAGCATGGTTTTCGTTTCAGGAATCTGTGCTGGAGTAAATTATC
TTTATACCCGTAAGCAAGAAGTCCATAGTGTCCTAGCCAGTAAGAAGTCGGTGAAGCTTTTTTACAGTATGTTACTCTTA
ATTAATTTGTTAGGAGCTGTTCTTGTTTTGTCAGATAACTTGTTCATCAAAAATACGCTGCAGCAAGAATTAGTTGACTT
TTTATTGCCATCCTTCTTTTTCCTATTTGGGCTAGATTTGCTGATTTTTTTACCCTTGAAAAAATACGTGCGCGATTTTC
TTGCTATGCTAGACAGAAAAAAGACAGTGTTGGTGACTATTTTAGCAACACTTCTTTTCTTAAGAAATCCAATGACCATT
GTCTCACTTCTGATTTATACTGGACTGGGCTTGTTTTTTGCAGCCTATCTTGTCCCAAATTCGGTTAAGAAGGAAGTTTC
CTTTTATGGTCATATTTTCCGAGATCTTGTATTGGTCATTGTTACGCTCATTTTCTTTTAG
ATGAAATCAATGAGAATCTTATTTTTGTTAGCTTTAATTCAAATCAGTTTGAGTAGCTGTTTCCTATGGAAGGAATGCAT
CTTGTCCTTTAAACAAAGTACAGCTTTTTTCATCGGAAGCATGGTTTTCGTTTCAGGAATCTGTGCTGGAGTAAATTATC
TTTATACCCGTAAGCAAGAAGTCCATAGTGTCCTAGCCAGTAAGAAGTCGGTGAAGCTTTTTTACAGTATGTTACTCTTA
ATTAATTTGTTAGGAGCTGTTCTTGTTTTGTCAGATAACTTGTTCATCAAAAATACGCTGCAGCAAGAATTAGTTGACTT
TTTATTGCCATCCTTCTTTTTCCTATTTGGGCTAGATTTGCTGATTTTTTTACCCTTGAAAAAATACGTGCGCGATTTTC
TTGCTATGCTAGACAGAAAAAAGACAGTGTTGGTGACTATTTTAGCAACACTTCTTTTCTTAAGAAATCCAATGACCATT
GTCTCACTTCTGATTTATACTGGACTGGGCTTGTTTTTTGCAGCCTATCTTGTCCCAAATTCGGTTAAGAAGGAAGTTTC
CTTTTATGGTCATATTTTCCGAGATCTTGTATTGGTCATTGTTACGCTCATTTTCTTTTAG
Domains
No domain identified.
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| comM | Streptococcus pneumoniae D39 |
99.515 |
100 |
0.995 |
| comM | Streptococcus pneumoniae R6 |
99.515 |
100 |
0.995 |
| comM | Streptococcus pneumoniae TIGR4 |
99.515 |
100 |
0.995 |
| comM | Streptococcus mitis NCTC 12261 |
38.462 |
94.66 |
0.364 |
| comM | Streptococcus mitis SK321 |
38.462 |
94.66 |
0.364 |